Gene Information

Name : megL (CLOST_2039)
Accession : YP_003937064.1
Strain : Clostridium sticklandii DSM 519
Genome accession: NC_014614
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 2167834 - 2169033 bp
Length : 1200 bp
Strand : -
Note : -

DNA sequence :
ATGAATAAAGATGCTTTAAAGAATATGGGATTTGCTACAAGAACTATACATGGTGGATATCAGAAAAATGAAATGGGAGC
TTTAGCTACTCCTATATACCAAACTTCTACATTTATTTTCGACAGCGCAGACCAAGGTGGAAAACGTTTTGCTGGAGAAG
AAGAAGGTTACATATACACAAGATTAGGAAATCCAAGTAATACTCCTGTAGAAGAAAAGCTAGCACTTTTAGAAGGAGCA
GAGGCATGTATGTCAATGGGCTCTGGAATGGGAGCAATCAGTTCAGCTCTTTGGACGGCTCTTAAGGCAGGGGATCACGT
AGTTGCAGCAGATACACTTTATGGCTGTACTTTTGCTCTTCTTAGCCATGGTATGCCTAGATACGGAGTAGAGGTTACTT
TCGTAGATACTAAGGATCCTCAAAATGTTAAGAACGCAATGAAGCCAAATACAAAGGTAGTTTATTTAGAAACACCAGCA
AACCCTACTTTAGATGTAGCTGATATAAGAGCAATAAGCGATATAGCTCACCAGAATGAAGGGTGCTTAGTAATGGTTGA
CAATACATTCTGTACACCATATATTCAAAGACCAATAGAGCTAGGAGCAGATGTTGTAGTTCACTCAGCGACTAAATATC
TTAATGGACATGGAGATGTAATAGCAGGATTCGTAGTAGGAACCAAAGCTTTTATAGATCAAGTGAGATTTTTTGGAGTA
AAAGATATGACTGGAGCAGTTCTTAGTCCATTTGATGCTTTCCTTATAGCTAGAGGTATGAAAACTCTTCATATCCGTAT
GGAGAAGCACTGTGAAAATGCAGTGAAAGTTGCTGAGTTTTTACGTAATCATCCTGCAGTAGATAAAGTATACTTCCCAG
GTTTTGAAGATTTCCCACAAGCTGAAATAGTTAAAAAACAAATGAGTCTTCCAGGAGCAATGATTGCTTTTGAAATAAAA
GGAGATATCGAAAAGGGTAAAAAGGTTATGGACACTGTTCATCTTTGCGTACTTGCTGTAAGCTTAGGAGACGCAGAAAC
ATTGATTCAGCATCCAGCATCTATGACTCACTCTCCATATACAGCAGAAGAAAGAGCAAAAGCGGGAATAAGCGATGGAT
TAATCAGACTTTCTGTAGGCTTAGAGAATCCTGAAGATATAATTGCAGATTTAAAGCAAGCCTTAGATGGTATTTTATAA

Protein sequence :
MNKDALKNMGFATRTIHGGYQKNEMGALATPIYQTSTFIFDSADQGGKRFAGEEEGYIYTRLGNPSNTPVEEKLALLEGA
EACMSMGSGMGAISSALWTALKAGDHVVAADTLYGCTFALLSHGMPRYGVEVTFVDTKDPQNVKNAMKPNTKVVYLETPA
NPTLDVADIRAISDIAHQNEGCLVMVDNTFCTPYIQRPIELGADVVVHSATKYLNGHGDVIAGFVVGTKAFIDQVRFFGV
KDMTGAVLSPFDAFLIARGMKTLHIRMEKHCENAVKVAEFLRNHPAVDKVYFPGFEDFPQAEIVKKQMSLPGAMIAFEIK
GDIEKGKKVMDTVHLCVLAVSLGDAETLIQHPASMTHSPYTAEERAKAGISDGLIRLSVGLENPEDIIADLKQALDGIL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-63 42
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-64 42
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-49 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_003937064.1 methionine gamma-lyase BAC0207 Protein 3e-99 56