Gene Information

Name : clpB (CLOST_1982)
Accession : YP_003937007.1
Strain : Clostridium sticklandii DSM 519
Genome accession: NC_014614
Putative virulence/resistance : Virulence
Product : protein disaggregation chaperone
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2115007 - 2117601 bp
Length : 2595 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor

DNA sequence :
ATGAACATGGAGAAATTAACTCAAAAGTCTCAAGAAGCCATAGTTCAATCACAAGAAATGGCTTTGAGACTTGGCCATCA
GCAGATGGAAACAGAGCATCTGCACTATGCACTGCTTGCAAGCGAGGATAGTCTCATATCCAAGCTACTGACTATGATGG
GAAAGAATGTCTCAGCAATTTTAATAGACCTTGGAAATCATCTAGATAAGCTTCCAAAGGTTCAAGGAGAGTCAGTAAGC
AGTGTATATCCATCCAGAAGATACAACGAAGTTCTTGTAAAAGCTCAAGACGAAGCTAAAGTATTTCAAGATGAATATAT
ATCTGTGGAGCATTTGTATCTTGCTGTTTTAGAGCAAAATCAAGGCTATACTAAAGACATCATCAGCAGATACCATATTG
ATAAAAATGAATTTCTTCAGGCTCTAAGCAAGGTGAGGAGTAATCAAAAAATAACTAGCCAAAACCCAGAGGATACCTAT
GATGTTCTAAACAAATACGGTAGAGATTTGGTTGAGATGGCTAGAAAAGGCAAGCTCGACCCTGTAATTGGAAGAGATGA
AGAAATAAGAAGAGCTATTAGGATTCTATCTAGAAGAACTAAAAACAATCCTGTGCTCATCGGAGAACCTGGAGTAGGTA
AAACTGCTGTAGTAGAAGGGCTTGCCCAAAGGATAGTAAATCACGATGTGCCAGAAGGCTTAAAGGATAAGACTATATTT
GCACTGGATATGGGAGCCCTCATAGCTGGAGCAAAATACAGAGGAGAGTTTGAAGAAAGGCTCAAAGCTGTACTAAATGA
AGTTTCAAAGTCAGAGGGACAAATTATTTTATTTATAGATGAGCTTCACACTATAGTAGGGGCAGGTAAAACTGAAGGTG
CAATGGATGCAGGAAACCTCTTAAAGCCTATGCTTGCAAGAGGAGAGCTTCACTGTATAGGAGCTACAACTTTAGATGAA
TATCGTAAATATATAGAAAAAGATGCAGCTCTAGAAAGAAGATTTCAGCCAGTTCTAGTAGACCAGCCAGATGTAGAGGA
TACCATATCCATATTAAGAGGGATAAAAGAGAAATTTGAAATTCATCATGGAGTTAGAATCACTGACAATGCTATTATTG
CCTGCGCAGTGCTGTCAAATAAATACATCTCAGACAGATTCCTGCCAGATAAAGCCATAGACCTTATGGATGAGGCAGCT
TCAATGATAAGAACAGAAATTGACAGCATGCCTACGGAGCTGGATGCAATAAGCAGAAAAATCATGCAGATGGAAATAGA
GCAGCAAGCGCTTAAAAAAGAAACAGATACATCATCAAAAGCAAGACTAGAAGACCTTCAAAAAGAGCTAGCAATATTAA
AAGAGCAGTATAGCTCAATGAAAAGTCAGTGGGAGCTAGAAAAAGAAAATATAATAAAAATAAAAGACCTACAAAAAGAA
ATAGAACAAACTAGACATAAGATAGAAGATGCAGAAAGAAGATATGATTTAGAAGAACTAGCTATGCTAAAGCATGGAAA
GCTTCCAGAGCTTGAGAAAAAGCTAGAAAGTGAAAGAGAAAATCAAGCAAAAAGTAAAGCCCAGCTATTAAAAGAAGAAG
TAACAGAAGACGAAATTGCTGAGATTATATCAAAATGGACAGGAATACCTGTAACAAAGCTAGTAGAAAGCGAAAGAGAA
AAACTACTGCATCTTCCTAGCCTTCTTCACAACAGAGTAATAGGACAAGACGAAGCAGTGGACTTAGTAGCTGATGCAGT
GCTAAGAGCAAGAGCGGGACTCAAAGACCCAAGAAGACCTATAGGCTCCTTCATATTCTTAGGACCTACAGGTGTAGGAA
AGACGGAGCTTGCAAAAGCTTTAGCCCAGGCTCTGTTTGACACTGAAGAGAATATCGTAAGAATAGATATGAGTGAATAT
CAGGAAAAGCATACAGTAGCTAGACTTATAGGAGCTCCTCCAGGATATGTAGGCTATGAAGAAGGTGGACAGCTCACTGA
AGCGGTAAGAAGAAAGCCATACAGCGTGATATTATTTGACGAGATAGAAAAGGCTCATCCAGAGGTATTCAATACCTTGC
TTCAGCTGCTTGATGATGGAAGATTGACAGACTCCAAAGGCAAGACTGTAAACTTCAAAGACACTGTAGTTATTATGACT
TCAAATATAGGAAGTAATCTACTTTTAGATGGTATGCAGGAATCTGGGGAAATCTCAGATGCAGTGAAAGAAAACGTACT
AAATACACTAAGAGCTAACTTTAAACCAGAGTTTTTGAACAGAATAGATGATATAGTGATGTTCAAACCTCTTACAAAGA
GTGAAATAGTAAAAATAGTAGAGCTTAGTCTAGTAGATATTCAAAATAGACTAAGTGATAGAAATATCAAGCTAGAAGTA
AGTGATGATGCAAAGAATTTCATTGCAGATAATTCCTACTCAAAAGTATACGGAGCAAGACCAGTAAAAAGGTATCTGCA
AAAGCATATAGAAACTCCTATTGCTAGATTGCTAATTCAAGGTGAAGTTCAAGATTATCAGACGATTTATATTGATAAGC
ATGAAGCAGACCTATCAATTGGCAGTAAAATCTGA

Protein sequence :
MNMEKLTQKSQEAIVQSQEMALRLGHQQMETEHLHYALLASEDSLISKLLTMMGKNVSAILIDLGNHLDKLPKVQGESVS
SVYPSRRYNEVLVKAQDEAKVFQDEYISVEHLYLAVLEQNQGYTKDIISRYHIDKNEFLQALSKVRSNQKITSQNPEDTY
DVLNKYGRDLVEMARKGKLDPVIGRDEEIRRAIRILSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVNHDVPEGLKDKTIF
ALDMGALIAGAKYRGEFEERLKAVLNEVSKSEGQIILFIDELHTIVGAGKTEGAMDAGNLLKPMLARGELHCIGATTLDE
YRKYIEKDAALERRFQPVLVDQPDVEDTISILRGIKEKFEIHHGVRITDNAIIACAVLSNKYISDRFLPDKAIDLMDEAA
SMIRTEIDSMPTELDAISRKIMQMEIEQQALKKETDTSSKARLEDLQKELAILKEQYSSMKSQWELEKENIIKIKDLQKE
IEQTRHKIEDAERRYDLEELAMLKHGKLPELEKKLESERENQAKSKAQLLKEEVTEDEIAEIISKWTGIPVTKLVESERE
KLLHLPSLLHNRVIGQDEAVDLVADAVLRARAGLKDPRRPIGSFIFLGPTGVGKTELAKALAQALFDTEENIVRIDMSEY
QEKHTVARLIGAPPGYVGYEEGGQLTEAVRRKPYSVILFDEIEKAHPEVFNTLLQLLDDGRLTDSKGKTVNFKDTVVIMT
SNIGSNLLLDGMQESGEISDAVKENVLNTLRANFKPEFLNRIDDIVMFKPLTKSEIVKIVELSLVDIQNRLSDRNIKLEV
SDDAKNFIADNSYSKVYGARPVKRYLQKHIETPIARLLIQGEVQDYQTIYIDKHEADLSIGSKI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 2e-153 42
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-107 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB YP_003937007.1 protein disaggregation chaperone VFG2084 Protein 3e-103 41