Gene Information

Name : clpB (CLOST_0160)
Accession : YP_003935195.1
Strain : Clostridium sticklandii DSM 519
Genome accession: NC_014614
Putative virulence/resistance : Virulence
Product : protein disaggregation chaperone
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 183842 - 186307 bp
Length : 2466 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor

DNA sequence :
ATGATGGAGAATTTTACAGAAAGAGCAAAGCAAGCCATAGAGCTTGCAAAGAGGGAAGCTAGCAAGCTAGGTCATAATAT
TGCTGGCAGTGAGCATATTCTTTTGGGACTGATGGCTGAAGGACAAGGAATAGCTTATCAAGTGCTATACAAATTTGGTC
TTACGCTTGAATCACTAGTAAGAGAAATAATAGATTTAGAGGGTATTGGACTTCCAAATACTCACTTTCAAGGCTTTAGC
CCTAGAACTAAAGGGATTTTTGAGCTGAGTATAATGGAAGCAAAAATGCTAGGCCATAGCTATATAGGTACTGAGCATTT
ACTTCTAGCCTTGCTAAAGGAAAAAGAGTGCATAGGATGCAGGCTTCTAATGGAAAAAGGTATAGACTATAATCTGGTAT
TTAAAGAGATTATGAATCTTCTTGGAGGAAGCAGTGCAGGCAAAGAGCCTAATCAAGCAGGAAATACAAGCTCTATGAAT
AGTCAAAATCCAAACACCCCTACACTTAACCAGTACGGTGTGGATTTGACCAAAGAAGCTGATGAAAACAGACTTGACCC
TGTAATAGGTAGAAGTAAAGAAATAGAAAGAATAATTCAAATTTTAAGTAGAAGAACTAAGAATAACCCTGTCCTTATAG
GCGACCCGGGTGTAGGAAAGACAGCTATAATAGAAGGACTAGCTCAAAAAATAAACTCGGGAGATATCCCATCTACCCTT
AAAAACAAGCGTATTATGACTCTCGAAATGGGAAACCTTCTTGCAGGAGCTAAGTACAGAGGCGAGTTTGAAGAGAGAGT
TAAAAAAATAGTAGAGGAATTAAAAGCAAATAAAGATGTGATTATATTTATAGATGAAATCCACAATCTAGCAGGAGCCG
GTGGAGCTGAAGGTGCTATAGATGCATCAAATATCATGAAGCCTGCACTAGCTAGAGGTGAAATCCAGGTTATGGGAGCT
ACTACTATAGATGAATACAGAAAGCACATAGAAAAGGATTCTGCTCTAGAGAGAAGATTCCAGACAGTAATGGTAGATGA
GCCTAACACTGAGGATTCTATAAAAATACTTCACGGCCTTAGAGATAGATATGAAGCTCACCATAAGGTAAAGATTACTG
ATGAAGCAATAAAGGCGGCCGTTGATTTATCGCATAGATATATCACTGATAGATTTTTGCCTGACAAAGCTATAGATTTA
ATAGATGAAGCAGCTTCTAGAGTAAGGCTTAGAAAATATATGGAGCCTGATAATATCAAGGAGCTAGAGGATAAACTATC
CAAGCTTTCTATGGAAAAGGAAGAAGCAATAGCTACTCAGGATTTTGAAAAGGCTGCTAAAATTAGAGATGAAGAAAAGC
AAATCAAAGAGCAGCTAGGCGAAAATAAAGAGCAGTGGACTAAGAAAAACTATACTAGCACTGAAGTAGTATTAGAAAAG
GACATAGCTGAAATAGTATCTTCATGGACAGGAGTTCCAGTTACTAGACTTCAAATGGAAGAATCTACTAAGCTTTTGGA
TTTAGAAAATATACTTCACAAAAGAGTTATAGGTCAAGAAGAAGCAGTAGAAGCTATATCAAGAGCCATAAGAAGAGCTA
GAACAGGTATGAAGGATCCAAAGAGACCTATAGGCTCATTTATATTCCTAGGGCCTACAGGAGTAGGAAAAACTGAGCTT
TCAAAGGCTTTAGCAGAAGCTATGTTTGAAGATGAGGATTCTATAGTTAGAATAGATATGAGTGAGTATATGGAAAAGCA
TTCTGTATCAAAACTCATAGGCTCTCCTCCAGGATATGTAGGCTATGATGAAGGCGGGCAGCTTACGGAAAAAATCAGAA
GAAAGCCATATTCTGTGGTATTATTTGATGAGATAGAAAAAGCTCATCCAGATGTATTTAATATGCTGCTTCAGATTCTA
GACGATGGAAGACTTACAGATTCTAAAGGACGTACTGTGGATTTCAAAAATACAGTGCTCATCATGACTTCAAACGTAGG
TGCAACTACTATCCAAAAGCAAAAGACTCTTGGATTTAGCACTGTAACAGATGAAGAAAAGAAAGAAAAAGCAGCTTACG
AAAAGATGAAGGACAATGTTATGGTTGAGCTTAAGAGAAGCTTTAAACCAGAGTTTCTAAATCGTGTAGACGATATTATA
GTATTCCATGCGCTTACAGATAGAGAGCTTGAAAAAATCGTATATCTAATGATATCAAATCTGGAAAAACGTCTTATGGA
TAAAAATATTACTATAGAGCTAGATGAGGCTGCAATGAAGCTCATCACTAAAAATGGCTATGATTTAGAGTTTGGCGCAA
GACCTCTAAAGCGTGCTATTCAAAGACTGCTTGAAGATGAAATCTCTGAAAAGCTTTTAAGAGGAGAAATAAATGATTCT
GACAATATAAAAGTTACAGCAGTGGATGACAAGCTAGATTTCGTAGTAAAGACAAAAACAGTTTAA

Protein sequence :
MMENFTERAKQAIELAKREASKLGHNIAGSEHILLGLMAEGQGIAYQVLYKFGLTLESLVREIIDLEGIGLPNTHFQGFS
PRTKGIFELSIMEAKMLGHSYIGTEHLLLALLKEKECIGCRLLMEKGIDYNLVFKEIMNLLGGSSAGKEPNQAGNTSSMN
SQNPNTPTLNQYGVDLTKEADENRLDPVIGRSKEIERIIQILSRRTKNNPVLIGDPGVGKTAIIEGLAQKINSGDIPSTL
KNKRIMTLEMGNLLAGAKYRGEFEERVKKIVEELKANKDVIIFIDEIHNLAGAGGAEGAIDASNIMKPALARGEIQVMGA
TTIDEYRKHIEKDSALERRFQTVMVDEPNTEDSIKILHGLRDRYEAHHKVKITDEAIKAAVDLSHRYITDRFLPDKAIDL
IDEAASRVRLRKYMEPDNIKELEDKLSKLSMEKEEAIATQDFEKAAKIRDEEKQIKEQLGENKEQWTKKNYTSTEVVLEK
DIAEIVSSWTGVPVTRLQMEESTKLLDLENILHKRVIGQEEAVEAISRAIRRARTGMKDPKRPIGSFIFLGPTGVGKTEL
SKALAEAMFEDEDSIVRIDMSEYMEKHSVSKLIGSPPGYVGYDEGGQLTEKIRRKPYSVVLFDEIEKAHPDVFNMLLQIL
DDGRLTDSKGRTVDFKNTVLIMTSNVGATTIQKQKTLGFSTVTDEEKKEKAAYEKMKDNVMVELKRSFKPEFLNRVDDII
VFHALTDRELEKIVYLMISNLEKRLMDKNITIELDEAAMKLITKNGYDLEFGARPLKRAIQRLLEDEISEKLLRGEINDS
DNIKVTAVDDKLDFVVKTKTV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 53

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB YP_003935195.1 protein disaggregation chaperone VFG0079 Protein 0.0 58
clpB YP_003935195.1 protein disaggregation chaperone VFG0080 Protein 7e-162 50