Gene Information

Name : HPSJM_00595 (HPSJM_00595)
Accession : YP_003928035.1
Strain : Helicobacter pylori SJM180
Genome accession: NC_014560
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase/cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 113564 - 114706 bp
Length : 1143 bp
Strand : -
Note : COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases

DNA sequence :
ATGCGCATGCAAACCAAATTAATCCATGGGGGCATTAGTGAAGACGCGACAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCACAAGGGCTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CTTTAGAAGAACTCATCGCTGATTTAGAAGGGGGGGTTAAGGGGTTCGCCTTCGCTTCTGGTTTAGCCGGAATCCACGCT
GTCTTTTCCCTCTTGCAATCAGGCGATCATGTGTTATTGGGCGATGATGTCTATGGGGGGACTTTCCGCTTGTTTAATAA
GGTGCTTGTCAAAAACGGGCTTTCATGTACCATTATAGACACTAGCGATCTATCCCAAATTAAAAAGGCTATCAAACCCA
ACACCAAAGCCCTTTATTTAGAGACCCCTAGTAACCCCTTGCTTAAAATCACCGATTTAGCGCAATGCGCCAGTGTCGCT
AAAGATCATGGTTTGCTCACTATCGTGGATAACACTTTCGCCACCCCCTATTGCCAAAACCCGCTTCTTTTGGGGGCGGA
CATTGTGGCGCATAGTGGCACAAAATACTTAGGCGGGCATAGCGATGTCGTCGCTGGGCTTGTAACCACCAATAATGAAG
CGCTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTGGGATTGCGCATGGAGGCTCATCAAAAAAACGCCCTTTGCGTGGCTGAATTTTTAGAAAAACACCC
TAAAGTGGAAAGGGTTTATTACCCGGGCCTTCCCACCCACCCTAATTACGAGCTAGCCAAAGCCCAAATGCGTGGTTTTA
GCGGGATGCTCTCTTTCATTCTTAAAAATGACAGCGAGGCGGCTCTTTTTGTAGAAAGCCTTAAATTATTCATTTTAGGC
GAGAGTTTGGGAGGGGTGGAAAGCTTGGTTGGGATTCCGGCGTTTATGACCCATGCGTGTATCCCTAAAGAGCAACGAGA
AGCCGCCGGGATTAGAGATGGTTTGGTGCGCTTGTCTGTAGGAATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAAGCTAA

Protein sequence :
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYCQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKAQMRGFSGMLSFILKNDSEAALFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-96 55
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-97 55
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-71 47

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSJM_00595 YP_003928035.1 cystathionine gamma-synthase/cystathionine beta-lyase BAC0207 Protein 5e-63 44