Gene Information

Name : HPPC_02715 (HPPC_02715)
Accession : YP_003926831.1
Strain : Helicobacter pylori PeCan4
Genome accession: NC_014555
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 534448 - 538050 bp
Length : 3603 bp
Strand : +
Note : -

DNA sequence :
ATGACTAACGAAACTATTGACCAACAACCACAAACCGGAGCGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
AGCTTTTCTTAAGCTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAACGATAGGGATA
ACAGGCAAGCTTTTGATGGAATCTCGCAATTAAGGGAAGAATACTCCAATAAAGCGATCAAAAATCCTACCAAAAAGAAT
CAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTAATCAACAAAGACAATCTCATTGATGTAGAATCTTCCACAAA
GAGCTTTCAGAAATTTGGGGATCAGCGTTACCGAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCA
ACACCCGATCGATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCCATGATGACAAAGAAAAAGCAGAGTTTTTG
AAATCTGCCAAGCAATCTTTTGCAGGAATCATCATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA
TGAATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTACTGGTGGGGATTGGTTGGATATTTTTCTCTCAT
TTATATTTAACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTCCCCATGTCCAACCAGATATA
GCCACTAGCACCACCCACATACAAGGCTTACCGCCTGAATCTAGGGATTTGCTTGATGAAAGGGGTAATTTTTCTAAATT
CACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGAGTTGCCGACATTGATCCTAATTACAAGTTCAATCAATTATTGA
TTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGCG
GGCAATGGTGGTTTTGGAGCCAAACACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTAC
AATAATTAATGTGCATATGAAAAACGGCAGTGGATTAGTCATAGCAGGTGGTGAGAAAGGGATTAATAATCCTAGTTTTT
ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGCCAAGAAGAGATCCAAAACAAAGTAGATTTCATG
GAATTTCTTGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAGGAAAAATTCCGAACTGAGATTGAAAA
TTTCCAAAAAAACCCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTATTGCTTTTGTTTCTAAAAAAGACCCAAAAC
ATTCAGCTTTAATTACTGAGTTTGGTAAGGGGGATTTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCT
TTAGATAGGGAGAAAAATGTCACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAA
ATACACCAACGCCTCCAAGAATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTAGACGCAGGCTTTAGCA
AGGTAGCTGTCTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTCGTAAGGCGGAATTTAGAGGATAAACTA
ACCGCTAAAGGATTGTCCCTACAAGAAGCTAATAAGCTTATCAAAGATTTTTTGAGCAGCAACAAAGAATTGGTTGGAAA
AGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAACTATGATGAAGTGAAAAAAGCTCAGAAAGATC
TTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGAGAAAAAATTGGAGAGCAAAAGCGGCAACAAAAAT
AAAATGGAAGCAAAATCTCAAGCTAACAGCCAGAAAGATGAGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGACGC
AAGAGCAATCGCTTACAGTCAAAATCTTAAAGGTATCAAAAGGGAATTGTCTGATAAGCTTGAAAGCATCAACAAGGATT
TGAAAGACTTTAGTAAATCTTTTGATGCACTCAAAAGTGGCAAAAATAAGGATTTCAGCAATGCAGAAGAAACGCTAAAA
GCCCTTAAAAGCTCGGTGAAAGATTTGGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA
TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATTCCGTTAAAGATG
TGATCATCAATCAAAAGGTAACGGATAAAGTTGATGATCTCAATCAAGCGGTATCAGTGGCTAAAGCAACGGGTGATTTC
AGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAATTTCTCAAAGGAGCAATTGGTTCAACAAGCTCAAAAAAATGAAAG
TTTCAATGTTGGAAAAAAATCTGAAATATACCAATCCGTTAAGAATGGTGTGAACGGAACCCTAGTCGGTAATGGGTTAT
CTCAAGCAGAAGCCACAACTCTTTCTAAAAACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTTTTGGAAATAAC
AATAACAATAACAATAATGGACTCAAAAACGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAG
CCCTGAAGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAACCCATTTACGCTC
AAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTGGTTTGGGTGGTGTAGGGCAAGCAGCG
GGCTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCGATCAGTTAGCCCTGAACCCATTTATGC
TACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAA
GGGAGCAAAAATTGGCTCAGAAAATTGACAATCTCAATCAGGCGGTGTCAGAAGCTAAAGCAGGTTTTTTTGGCAATCTA
GAGCAAACGATAGACAAGCTCAAAGATTCTACAAAAAACAATACTGTGAATCTATGGGCTGAAAGTGCAAAAAAAGTGCC
TGCTAGTTTGTCAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATATCCACAATGGAGCAA
TCAATGAAAAAGCGACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAAATAGTTGCACAT
AATGTAGGAAGCGTTCCTTTGTCAGAGTATGATAAAATTGGCTTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTT
CAAGTTTTCCACCAAGTTGAACAATGCTGTAAAAGACGTTAAGTCTGGCTTTACGCAATTTTTAGCCAATGCATTTTCTA
CAGGATATTACTGCTTGGCGAGGGAAAATGCGGAGCATGGAATCAAAAATGTTAATACAAAAGGTGGTTTCCAAAAATCT
TAA

Protein sequence :
MTNETIDQQPQTGAAFNPQQFINNLQVAFLKLDNAVASFDPDQKPIVDKNDRDNRQAFDGISQLREEYSNKAIKNPTKKN
QYFSDFINKSNDLINKDNLIDVESSTKSFQKFGDQRYRIFTSWVSHQNDPSKINTRSIRNFMENIIQPPIHDDKEKAEFL
KSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGEPTGGDWLDIFLSFIFNKKQSSDVKEAINQEPVPHVQPDI
ATSTTHIQGLPPESRDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYA
GNGGFGAKHDWNATVGYKDQQGNNVATIINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNKVDFM
EFLAQNNAKLDNLSEKEKEKFRTEIENFQKNPKAYLDALGNDRIAFVSKKDPKHSALITEFGKGDLSYTLKDYGKKADKA
LDREKNVTLQGSLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLDAGFSKVAVFNLPDLNNLAITSFVRRNLEDKL
TAKGLSLQEANKLIKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVEKKLESKSGNKN
KMEAKSQANSQKDEIFALINKEANRDARAIAYSQNLKGIKRELSDKLESINKDLKDFSKSFDALKSGKNKDFSNAEETLK
ALKSSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDVIINQKVTDKVDDLNQAVSVAKATGDF
SRVEQALADLKNFSKEQLVQQAQKNESFNVGKKSEIYQSVKNGVNGTLVGNGLSQAEATTLSKNFSDIKKELNAKLFGNN
NNNNNNGLKNEPIYAKVNKKKTGQVASPEEPIYAKVNKKKTGQVASPEEPIYAQVAKKVNAKIDRLNQIASGLGGVGQAA
GFPLKRHDKVDDLSKVGRSVSPEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSREQKLAQKIDNLNQAVSEAKAGFFGNL
EQTIDKLKDSTKNNTVNLWAESAKKVPASLSAKLDNYATNSHTRINSNIHNGAINEKATGMLTQKNPEWLKLVNDKIVAH
NVGSVPLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDVKSGFTQFLANAFSTGYYCLARENAEHGIKNVNTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 93
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 92
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 92
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 91
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 90
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 90
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 90
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 90
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 89
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 85
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 84
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 84
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 83
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 83
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 80
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 79
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 78
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 78
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 68
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 68
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 68
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 67

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPPC_02715 YP_003926831.1 cytotoxin-associated protein A VFG0306 Protein 0.0 92