Gene Information

Name : metB (AARI_07010)
Accession : YP_003915894.1
Strain : Arthrobacter arilaitensis Re117
Genome accession: NC_014550
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 774605 - 775828 bp
Length : 1224 bp
Strand : +
Note : catalyzes the conversion of cysteine and succinyl- homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms

DNA sequence :
ATGAGCGGCTTCAACACCCTGGCCGTGCACGCCGGCCAGCACAAGGATCCGCACACCGGTGCGGTGATCCCGCCGATCTA
CCAGACCAGCACCTTCATCCAGGACGGCATCAACGTGCTGCGCGCCGGGCACGAGTACTCGCGCGGCTCCAACCCGACCC
GCAACGGCTTCGAATCCCAGCTCGCCGCGCTGGAAGGCGGCGCCGCCGGCTTCTCCTTCGCTTCGGGGATCGCCGCCGAA
GACGCACTGCTGCGCGCAGTGCTGGAACCGGGCGACCACATCATCCTGGGCGCCGACGGCTACGGCGGCACCAACCGGCT
GATCTCCAAGCTGCACGGCAAATGGGGGATCACCTCTTCCGCGGTGGACATCACCAACCTGGATGCGGTGCGCGCCGCGG
TGCGCCCGAACACCGCGCTGCTCTGGGTGGAGACCCCGTCCAACCCGCTGCTGGGCATCGCCGACCTGGCCGGCTGGGCA
GCCATCGCGGCCGAGCACGGCGCCCTGCTGGTGGTGGACAACACCTTCGCCACCCCGTACCTGCAGCGGCCGCTGGATTT
CGGCGCCCACGCGGTGGTCCATTCCACCACCAAGTACATCGGCGGGCACTCCGATGTGCTCGGTGGCGCTGTCATCGTGG
CCGACCACCTGCACCGCGGGCAGAGCCTGGCCGAAGCCGTGGGCTACCAGCAGTTCGCCGGGGGAGCGGTCTCCGGTCCG
CAGGATTCCTACCTGGCCGCCCGCGGGCTGAAGACCCTGGGCCTGCGCATGGAACGCCACGGGGCTACCGCCTCCACCCT
GGCCCGCTGGCTCGATGACCAGCCCGAAGTCACCCGCGTCTACTACCCGGGACTGGAACGCCATCCGGGCCACGAGCTGG
CCAAATCCCAGTCCGCGGCCGGCCGCGGCTTTGGCGGGATCCTCTCCTTGCAGCTCTCTGATGAAGCCGCCGCCCGCGCC
TTCGCCCAATCCATGGAGTACTTCCAGCTCTCGGTCTCCCTGGGCGGGGTGGAATCCCTGGTCTGCTATCCGCGCGAAAT
GACCCATGCTTCGCTGATCGGCACCCCGCTGGAAATCCCGGCCAACCTGGTCCGCCTCTCGGTGGGCATCGAGGAAGCCG
ACGACCTGATTGCTGATCTGGAACGCGGCCTGGCCGCCGCCCGGGCGACCCAGCCGGTACACAAGCCCGCCGTCGTGCGC
GAGAAGGCCCTAGAAAACGCCTGA

Protein sequence :
MSGFNTLAVHAGQHKDPHTGAVIPPIYQTSTFIQDGINVLRAGHEYSRGSNPTRNGFESQLAALEGGAAGFSFASGIAAE
DALLRAVLEPGDHIILGADGYGGTNRLISKLHGKWGITSSAVDITNLDAVRAAVRPNTALLWVETPSNPLLGIADLAGWA
AIAAEHGALLVVDNTFATPYLQRPLDFGAHAVVHSTTKYIGGHSDVLGGAVIVADHLHRGQSLAEAVGYQQFAGGAVSGP
QDSYLAARGLKTLGLRMERHGATASTLARWLDDQPEVTRVYYPGLERHPGHELAKSQSAAGRGFGGILSLQLSDEAAARA
FAQSMEYFQLSVSLGGVESLVCYPREMTHASLIGTPLEIPANLVRLSVGIEEADDLIADLERGLAAARATQPVHKPAVVR
EKALENA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-63 46
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-64 46
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 8e-45 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_003915894.1 cystathionine gamma-synthase BAC0207 Protein 1e-50 43