Gene Information

Name : clpB2 (STHERM_c13390)
Accession : YP_003874553.1
Strain : Spirochaeta thermophila DSM 6192
Genome accession: NC_014484
Putative virulence/resistance : Virulence
Product : chaperone ClpB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 1455071 - 1457683 bp
Length : 2613 bp
Strand : -
Note : -

DNA sequence :
ATGGATCTCGAACGTTTCACGGTGAAGGCCCAGGAGGCCCTCCAGAACGCCGCCAAGCTCATGCACCAGTACGATCACAC
CCTCCTCGAACCGGAGCACATCGCCCTTGCGATCGTCCAGCAGGAGGATGGGATCATCAAGCCCCTCGTGGAACGGCTGG
GTGCCTCTCGCGCCCAGATCGAGCACGAGCTCGTGGCCCTTCTTGAGAAAAAGCCGAAGGTCTACGCAGAGGGTGCTTCC
ACCTCGGGGGTGAGCCTCTCCAACCAGGCGGCACGGGTCCTCAGCAAGGCCGAGGTGGAGGCCAAGCGCATGCAGGACGA
GTACGTGAGCGTGGAACACATCCTCCTCGCCCTCGCCCAGGAGCCGGGTGAGGTGGCGCGGGTGTTCCAGCGCAACGGGC
TCACGTACGAAGGGATCTCGCACGCGATCCAGGGGATCCGCCAGGGGAGGCGGGTGACGAGCCAGGACCCCGAGAGCACC
TATCAGGCCCTCGAGAAGTACTGTCGCGACCTCACCGCCCTCGCCCGCCAGGAAAAGCTCGACCCGGTGATAGGCCGGGA
CGAGGAGATACGCCGGATGATCCAGGTCCTCCTCAGGCGCACCAAAAACAACCCGGTGCTCATAGGTCCCCCGGGCGTGG
GTAAGACGGCCATCGTGGAGGGCCTGGCCCGAAGGATCGTGGCAGGCGACGTGCCCGATTCCCTCAAGGACAAGCGGATC
CTGGCGCTCGACCTCGGGGCACTCGTGGCAGGGGCCAAGTACCGCGGCGAGTTCGAGGAACGACTCAAGGCCGTGATCAA
CGAGGTGATTGCCTCTGAGGGAAAGATCATCCTCTTCATCGATGAGCTGCACACCCTCATCGGTGCGGGTGCGGCCGAGG
GTGCCACCGACGCCGCGAACCTCCTCAAGCCCCCGCTCTCCCGCGGTGAACTGCGCACCATCGGTGCCACCACGGTGGAC
GAGTACCGCAAGCATATCGAGAAGGACGCGGCCTTCGAGCGCCGATTCCAGCCCATCTCCGTGGCAGAACCCTCGGTGGA
GGACACCATCTCCATCCTCCGCGGGCTCAAGGAGCGCTACGAGGTACACCACGGGGTGCGCATCACCGACGAGGCCATCG
TGGCCGCGGCGGTGCTCTCGGACAGGTACATCACCTCGCGCTTCCTCCCGGACAAGGCCATCGACCTCATCGACGAGGCG
GCCAGCCGGCTTAAGATGGAGATCGAGAGCATGCCCACCGAGATCGACCAGCTCGACAGGAAGATCCTCCAGCTCACCAT
AGAACGGCAGGCCCTCTCCAAGGAGAAGGACCCCGCCTCTCAGGAGCGGCTCAAGAAGATCGAACAGCAGCTTTCCCAGC
TCAAGGAAGAGCGCGACAAGCTCTACCTCAAGTGGCAGAACGAGAAGAAGATCATCGACGAGATCCGGAAGCTCAACGCC
GAGATCGAGGATCTCACCATTCGGGAGACCCAGTACGAGCGTCAGGGCAACCTCGACAAGGCCGCCGAGATAAAGTACGG
CCTCCTTCCCCAGAAGCGACGTGAGCTCGAGGAGAAGACCAGGGCGCTCGAGCGGCTTAAGGGCGAGGAGAGTTCGCTCC
TGAGGGAAGAAGTGACCGAGGAGGACATCGCCCGCGTGGTCTCGAGCTGGACCGGGATCCCGGTGACCAAGATGATGGCC
TCGGAGAAGGAGAAGCTCCTCCACCTCGAGGAGGTGCTCGGCAGGCGGGTGATCGGCCAGGAGGAGGCCATCAGGGCCGT
GGCCGACGCCATAAGGAGGAACAGGAGCGGCCTCTCCGACCCGAGACGGCCCATGGGTGTCTTCCTGTTCCTCGGTCCCA
CCGGGGTGGGGAAGACGGAGCTCGCCCGTACCCTGGCCGACTACCTCTTCAACGACGAGCGGGCCATGGTGCGCATCGAC
ATGAGCGAGTACATGGAGCGGCATGCGGTCTCCAGGCTCATCGGGGCACCTCCCGGTTACGTGGGGTACGAGGAAGGTGG
ACAGCTCACCGAGGCCGTGCGGAGGCGGCCGTACTCCGTGGTGCTCTTCGACGAGGTGGAGAAGGCCCATCCCGACGTGT
TCAACATCATGCTCCAGATCTTCGACGACGGAAGGCTCACCGACAGCCAGGGCCACGTGGTCGACTTCAAGAACACCATC
GTCATCATGACCAGTAACATAGGGAGCGACCTCATCCTTGAGGCCGACGACCTGGAGAAGGTCAAACCGCAGGTCAACAG
CCTCCTGCGGGCGAGCTTCAAGCCCGAGTTCCTCAACCGGATCGACGAGATGATCGTCTTCCACAGGCTCACGCAGGAGC
ACATCTACAAGATCCTCGACCTCGAAATAGAGCGCCTCAACGAGCGGCTTTCGGAGCAGCACCTCTCCATAGAGGTGGAT
CAAAAGGCCAAGGATATCCTGGTGAGGGAAGGCTTCAGCCCCGAGTTCGGCGCACGGCCGCTCAAGCGCACCGTACAGCG
CCTCATCTACAACCCCCTTGCAAAAGAGCTCATTGCAGGCAAGTATAAAGAGGGTGATACCGTGTACGTGACCGCCGAGC
ACGGCCAGCTCGTCTTCACACGGAAAGTAGGAGAGGCAGTAGCCTCTTCATAG

Protein sequence :
MDLERFTVKAQEALQNAAKLMHQYDHTLLEPEHIALAIVQQEDGIIKPLVERLGASRAQIEHELVALLEKKPKVYAEGAS
TSGVSLSNQAARVLSKAEVEAKRMQDEYVSVEHILLALAQEPGEVARVFQRNGLTYEGISHAIQGIRQGRRVTSQDPEST
YQALEKYCRDLTALARQEKLDPVIGRDEEIRRMIQVLLRRTKNNPVLIGPPGVGKTAIVEGLARRIVAGDVPDSLKDKRI
LALDLGALVAGAKYRGEFEERLKAVINEVIASEGKIILFIDELHTLIGAGAAEGATDAANLLKPPLSRGELRTIGATTVD
EYRKHIEKDAAFERRFQPISVAEPSVEDTISILRGLKERYEVHHGVRITDEAIVAAAVLSDRYITSRFLPDKAIDLIDEA
ASRLKMEIESMPTEIDQLDRKILQLTIERQALSKEKDPASQERLKKIEQQLSQLKEERDKLYLKWQNEKKIIDEIRKLNA
EIEDLTIRETQYERQGNLDKAAEIKYGLLPQKRRELEEKTRALERLKGEESSLLREEVTEEDIARVVSSWTGIPVTKMMA
SEKEKLLHLEEVLGRRVIGQEEAIRAVADAIRRNRSGLSDPRRPMGVFLFLGPTGVGKTELARTLADYLFNDERAMVRID
MSEYMERHAVSRLIGAPPGYVGYEEGGQLTEAVRRRPYSVVLFDEVEKAHPDVFNIMLQIFDDGRLTDSQGHVVDFKNTI
VIMTSNIGSDLILEADDLEKVKPQVNSLLRASFKPEFLNRIDEMIVFHRLTQEHIYKILDLEIERLNERLSEQHLSIEVD
QKAKDILVREGFSPEFGARPLKRTVQRLIYNPLAKELIAGKYKEGDTVYVTAEHGQLVFTRKVGEAVASS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 3e-156 44
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 7e-104 43
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 4e-97 42
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 3e-97 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB2 YP_003874553.1 chaperone ClpB VFG0079 Protein 2e-169 47
clpB2 YP_003874553.1 chaperone ClpB VFG2076 Protein 6e-115 44
clpB2 YP_003874553.1 chaperone ClpB VFG2084 Protein 1e-101 43