Gene Information

Name : mccB (BSUW23_13180)
Accession : YP_003866983.1
Strain : Bacillus subtilis W23
Genome accession: NC_014479
Putative virulence/resistance : Resistance
Product : bifunctional cystathionine gamma-lyase/homocysteine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 2578123 - 2579262 bp
Length : 1140 bp
Strand : -
Note : -

DNA sequence :
ATGAAGAAAAAAACATTGATGATACATGGCGGAATTACAGGTGATGAAAAAACAGGCGCGGTTTCTGTGCCCATTTATCA
AGTAAGCACGTACAAGCAGCCGAAAGCAGGACAGCATACAGGCTATGAGTATTCAAGAACGGCCAATCCGACTAGAACCG
CTCTCGAAGCACTAGTGACAGAGCTGGAAGGCGGGGAAGCAGGCTATGCATTTAGTTCAGGAATGGCTGCCATTACAGCA
GTTATGATGTTGTTTAACAGCGGAGATCATGTCGTGTTGACTGATGATGTGTACGGCGGAACATACCGCGTGATGACAAA
GGTACTAAATCGTCTTGGCATTGAATCAACATTTGTCGATACAAGCTGCAGAGAAGAAGTTGAAAAAGCGATTCGCCCAA
ACACAAAAGCCATTTATATTGAGACACCGACAAACCCGCTGCTCAAAATCACCGACTTGGCACTCATGGCTGATATCGCA
AAAAAAGAGGGTGTTCTGCTTATCGTCGACAATACCTTTAACACTCCTTATTTTCAGCAGCCGCTCACTTTAGGAGCTGA
TATTGTGCTTCACAGTGCGACAAAATATCTTGGCGGACACAGTGACGTCGTCGGCGGTTTAGTTGTGACAGCTTCGAAAG
AGCTTGGCGAAGAGCTGCATTTTGTGCAAAACTCCACAGGCGGCGTCCTTGGCCCTCAAGATTCCTGGCTGTTAATAAGA
GGAATCAAAACATTGGGACTCAGAATGGAAGCGATCGATCAAAATGCGCGGAAAATCGCAAGTTTTCTGGAGAATCATCC
TGGTGTCCAAACGTTATATTATCCTGGTTCTTCAAATCATCCCGGACATGAGCTCGCAAAAATACAAGGGTCTGGCTTCG
GTGGCATGATCTCCTTTGATATCGGCAGTGAAGAGCGGGTTGATGCATTTTTAGGGAATCTGAAACTGTTTACCATTGCT
GAAAGTCTTGGCGCAGTAGAAAGCTTAATTTCTGTTCCGGCAAGAATGACACATGCCTCTATTCCGAGAGAGCGCCGGCT
TGAATTAGGCATTACGGACGGATTGATTAGAATTTCTGTAGGAATTGAAGATGCGGAAGATTTACTGGAAGATATCAAGC
AAGCGCTTGAAAATATATAA

Protein sequence :
MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEYSRTANPTRTALEALVTELEGGEAGYAFSSGMAAITA
VMMLFNSGDHVVLTDDVYGGTYRVMTKVLNRLGIESTFVDTSCREEVEKAIRPNTKAIYIETPTNPLLKITDLALMADIA
KKEGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEELHFVQNSTGGVLGPQDSWLLIR
GIKTLGLRMEAIDQNARKIASFLENHPGVQTLYYPGSSNHPGHELAKIQGSGFGGMISFDIGSEERVDAFLGNLKLFTIA
ESLGAVESLISVPARMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIKQALENI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-109 59
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-108 58
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-75 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mccB YP_003866983.1 bifunctional cystathionine gamma-lyase/homocysteine gamma-lyase BAC0207 Protein 7e-68 44