Gene Information

Name : Toce_1727 (Toce_1727)
Accession : YP_003826085.1
Strain : Thermosediminibacter oceani DSM 16646
Genome accession: NC_014377
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 1721307 - 1723457 bp
Length : 2151 bp
Strand : -
Note : COGs: COG2217 Cation transport ATPase; Contains selenocysteine; InterProIPR006404:IPR006416:IPR001757:IPR006121:IPR 008250:IPR005834:IPR001366:IPR018303; KEGG: gsu:GSU2147 cadmium-translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein;

DNA sequence :
ATGGGAGCTGAAGAAAAGCTATACAGGGTTAATGAAAAAAAGGTGTACAGAGTCGAAGGCATAACCTGACTCGATTGTGC
TGCCAAGTTTGAAAGAAACGTGGCAGCACTGCCCGGTGTTACCAGGGCTGTCTTAAACCCGGCGACGGGTAGGCTCACCG
TGGAAGGCAATGTGGACATTGACGCTATCCGGCGGGAAGGCCTTAAAGAAAACTATAAAATATTCCCGGCCGAGGAAAAA
GAGGAGCGGGCTCAGGCGGGGACAGGAATTAAGATAAACAAAGAATTGCTCCGGACGGTGGTATCCGCAGCTGCTCTTTT
GGCGGCTTATATCGGGAGAAAAGTGGGTGTGATAGCTTACTTTTATGTCCCTCTGTTCCTGCTTGCCATGGTCGCCGGGG
GCTGGGAGAATTTCCGGAAGGCCTATTATTCTTTAAGACGACTTAATTTGAATATGAGCGTTCTAATGAGCATAGCTGTC
ATAGGAGCAGTGGCAATCGGCGAGCTGGAGGAGGGTGCCGTTGTGGCATTCCTGTACTCGGTTTCGGAAATGCTGGAATC
CTGGACCATGGAGAGAGCGAGACGGTCGATACGCCTGCTCATGGACATAGCACCCAAAACCGCAAGAATAAAAAAGCCGT
GGGGCGAAGTGGATGTCCCCGTAGATGAAATTAATATTGGCGATATAATTGTAATCCGTCCCGGCGAGAAAATAGCCATG
GACGGGGTCATACTAAAGGGCGAGTCGGCGATAAACGAGGCTGCTATCACCGGAGAATCGATACCCGCCGAAAAGGGGCC
CGGTGACGAGGTTTATGCGGGGACCATTAACACTCACGGCTCGCTGGAAGTAAAAGTTACGAAACTCGTTCAGGATACCA
CCCTGGCGAAAATTATACACCTGGTTGAGGAGGCCCAGACAAGACGCGCTCCGGTTCAGGCTTTTGTGGACCGGTTTGCA
GCTGTATATACACCAATAGTGATTGTGCTCGCCGGCGCCGTAGCACTGGTGCCGCCGCTTTTCCTGGGCCATGAATGGAC
GCCATGGCTGTACCGCGGCCTCGCTTTGCTGGTGGTATCGTGTCCGTGCGCTCTTGTGGTTTCAACGCCTGTAGCTGTAG
TAAGTGCTATAGGTAACGCGGCAAGGAACGGAGTCTTAATAAAAGGCGGAATATACCTTGAAGAAGCTGGTTCTTTAAAG
GTTGTCGCTCTTGACAAGACCGGTACTCTTACGAGAGGAAAGCCGGTGGTTACCGATGTAATAGCTGTAGGTAACGAATC
TGAAACAGAGGTTCTTCGCAAGGCTGCCAGCGTAGAAAAGCGATCGGAACACCCCCTTGCCGTTGCCATAGTTAAAGCCG
CGGAAGCCCGGGGTGTAGAAATGATACCGGCAGAAGATTTTACTGCTTTCACAGGCCGGGGGGCAAGAGGTTCCGTGGAC
GGAGAGGCGCTATTTGTAGGAAATATGAAGTTTTTTGAGGAACTGGGTGTAGAGGCCGGTGGAATAACGGAGGACGTAAA
GCGCCTTCAGGAAGAAGGCAAGACGGCTATGCTGGTGGGGACGGAAAACGGTATTATAGGAATTATTGCCGTTGCCGACG
AGATAAGGGAAACGAGCAAAAAGGCTTTGGCCTTACTCAAACGCGCCGGCATCGAGCGGACGATAATGCTTACCGGCGAT
AATAAAGCCACTGCTAAAGCTGTAGCCGCCCGCGCCGGTGTCGATGAGTTTTTAGCCGAACTGCTGCCTCAGGATAAGGT
AAGAGCCCTCGAAGATTTGATAAAAAAATACGGGAAGGTTGCCATGGTGGGGGATGGTATAAATGACGCTCCCGCACTGG
CTGCAGCTACCTTAGGAATAGCCATGGGCGGGACCGGTACCGATACGGCCCTTGAGACGGCGGACATAGTGTTAATGACC
GACGACCTGACTAAAGTGGCGTTTACGATCCGCCTGAGCAGAGCTGCACTGCAGGTGATACGCCAGAATATAACATTGTC
GCTGGTCATTAAAGCCCTGGCGGTGGCGGCCGTTTTCCCGGGGTGGTTGACGCTGTGGCTGGCCATTCTGGCCGATATGG
GAGCGACTTTACTGGTGACTCTCAACGGAATCAGGTTGTTGAAAATAAAGAAGTTGGAAGAAAGGACTTAA

Protein sequence :
MGAEEKLYRVNEKKVYRVEGITULDCAAKFERNVAALPGVTRAVLNPATGRLTVEGNVDIDAIRREGLKENYKIFPAEEK
EERAQAGTGIKINKELLRTVVSAAALLAAYIGRKVGVIAYFYVPLFLLAMVAGGWENFRKAYYSLRRLNLNMSVLMSIAV
IGAVAIGELEEGAVVAFLYSVSEMLESWTMERARRSIRLLMDIAPKTARIKKPWGEVDVPVDEINIGDIIVIRPGEKIAM
DGVILKGESAINEAAITGESIPAEKGPGDEVYAGTINTHGSLEVKVTKLVQDTTLAKIIHLVEEAQTRRAPVQAFVDRFA
AVYTPIVIVLAGAVALVPPLFLGHEWTPWLYRGLALLVVSCPCALVVSTPVAVVSAIGNAARNGVLIKGGIYLEEAGSLK
VVALDKTGTLTRGKPVVTDVIAVGNESETEVLRKAASVEKRSEHPLAVAIVKAAEARGVEMIPAEDFTAFTGRGARGSVD
GEALFVGNMKFFEELGVEAGGITEDVKRLQEEGKTAMLVGTENGIIGIIAVADEIRETSKKALALLKRAGIERTIMLTGD
NKATAKAVAARAGVDEFLAELLPQDKVRALEDLIKKYGKVAMVGDGINDAPALAAATLGIAMGGTGTDTALETADIVLMT
DDLTKVAFTIRLSRAALQVIRQNITLSLVIKALAVAAVFPGWLTLWLAILADMGATLLVTLNGIRLLKIKKLEERT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 6e-152 51
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-152 51
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-152 51

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Toce_1727 YP_003826085.1 heavy metal translocating P-type ATPase BAC0298 Protein 6e-111 50
Toce_1727 YP_003826085.1 heavy metal translocating P-type ATPase BAC0100 Protein 1e-64 44
Toce_1727 YP_003826085.1 heavy metal translocating P-type ATPase BAC0092 Protein 3e-85 43