Gene Information

Name : Toce_1559 (Toce_1559)
Accession : YP_003825924.1
Strain : Thermosediminibacter oceani DSM 16646
Genome accession: NC_014377
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 1535599 - 1536804 bp
Length : 1206 bp
Strand : -
Note : COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR006237:IPR000277; KEGG: cko:CKO_04984 hypothetical protein; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: Methionine gamma-lyase; TIGRFAM: methionine

DNA sequence :
ATGGGATTCAATACCAAAGCCGTTCACGCGGGACAAAAACACGACCCGGTAACGGGGTCCCACGTGACGCCGATTTATCA
GACGTCAACCTTTGTTTTTGAAAACGTGGACCAGGGGGCGCGCCGTTTTGCAGGCCAGGAAGAAGGTTATATATATACCA
GGCTTGGAAACCCAACCATAACGGAACTTGAAGAAAAGATGGCAGTCCTCGAAGGCGGTGAAGCTGCCATAGCCACCGCT
TCCGGTATGGCGGCCATTTCAACGGTGCTCTTTACCCTGTTAAAACAAGGGGACCATGTGGTGGCAAGTGATGCGCTGTA
CGGATGCACTCACAGCTTTTTAAGCCATGTGGCACCCAAATACGGTATAGATGTTACTTTCACGGATGCTTCTGACCTGA
CGAATCTTGAAAAGGCTATGAAACCCAATACAAAAGTTGTTTATGTGGAGACACCGGCCAACCCCACGCTGAAGCTGATT
GACCTTAAAGGTGCCGCAGAAATAGCCCATAAGTTCGGAGCAAGGCTGGTGGTCGACAATACCTTCATGTCGCCGTATCT
GCAGAGGCCTATAGAACATGGGGCGGACGTGGTGGTCCACAGCGCCACCAAGTATATCGGCGGCCACGGTGACGTCATAG
GAGGTATAATCGTCGGCCCGAAAGACCTGATAACTGAAATGAAGATGCCGTATCTCAAGGATATCGGAGGCGTAATAGGC
CCCTTTGACGCCTGGCTCCTCATCAGAGGATTGAAAACTCTGGGATTGCGCATGGAGCGCCACTGCCAGAATGCGCAGAA
GGTGGCCGAATACCTGGAAGGCCATCCAATGATCGAGAGAGTCTACTATCCGGGTTTACCATCCCATCCGCAGCATGACC
TGGCCAAGCGGCAGATGGACGGCTTCGGCGGCATGATAAGCTTCGAGCTCAGAGGCGGAATCGAGGCAGGAAAGCTGTTG
ATGAACAGTGTAAAAATGATAACGCTGGCTGTAAGCCTCGGTTGTGTCGATTCTCTGATCCAGCATCCAGCATCTATGAC
CCATTCCCCCGTTCCTAGGGAGGAGAGGCTGAAGGCCGGAATAACCGACGGTCTGGTTAGACTGTCCGTTGGTATAGAGG
ATGTGGAGGATATAATTGGAGACCTGGATCAAGCCCTTGAAAAGGTGCAGAAGGGGTTAAAAGATGGATTTTCAACCGGG
GCCTAA

Protein sequence :
MGFNTKAVHAGQKHDPVTGSHVTPIYQTSTFVFENVDQGARRFAGQEEGYIYTRLGNPTITELEEKMAVLEGGEAAIATA
SGMAAISTVLFTLLKQGDHVVASDALYGCTHSFLSHVAPKYGIDVTFTDASDLTNLEKAMKPNTKVVYVETPANPTLKLI
DLKGAAEIAHKFGARLVVDNTFMSPYLQRPIEHGADVVVHSATKYIGGHGDVIGGIIVGPKDLITEMKMPYLKDIGGVIG
PFDAWLLIRGLKTLGLRMERHCQNAQKVAEYLEGHPMIERVYYPGLPSHPQHDLAKRQMDGFGGMISFELRGGIEAGKLL
MNSVKMITLAVSLGCVDSLIQHPASMTHSPVPREERLKAGITDGLVRLSVGIEDVEDIIGDLDQALEKVQKGLKDGFSTG
A

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-67 45
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-65 44
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-60 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Toce_1559 YP_003825924.1 methionine gamma-lyase BAC0207 Protein 6e-88 54