Gene Information

Name : Closa_4110 (Closa_4110)
Accession : YP_003824241.1
Strain : Clostridium saccharolyticum WM1
Genome accession: NC_014376
Putative virulence/resistance : Resistance
Product : winged helix family two component transcriptional regulator
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 4449517 - 4450227 bp
Length : 711 bp
Strand : -
Note : KEGG: dhd:Dhaf_4626 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver

DNA sequence :
ATGGAAATCAAGCCAACGGTATTGATCATTGAAGATGAGGATGCGATCTGCAATTTTATATCTGCCATTCTGTCCTCAAA
CGGTTATCAGGTGGTGAAGGCTAAAACAGGGAAGGAAGGGCTTTCCCTGTTCACTTCCCATGTTCCCGATCTCATCCTTC
TGGACCTGGGCCTGCCGGACATTGACGGCATAGAGATACTGAAAAATTTACGCCAATGGTCAAAAACACCTGTGATCGTT
GTCTCCGCCAGGGGCTATGAGCGTGAAAAGGTGGCGGCCCTGGATTTTGGGGCGGATGATTACATTGTGAAACCCTTCGG
TACTTCGGAACTGCTGGCCCGGATACGGACGGCCATGCGTCACAGCCCCCAGGCAGCAGGAACGGAAGTGTGGGGAGAAG
AAAAAGTAACCATTGGAAAACTTGCGATTGATTACGGCAAACGGACGGTATACAAAGCCGGGGAAAAGATCCATTTAACC
CCAATAGAATATAAGCTGCTGGTCCTCCTGTCTAAAAATGCAGGCAAGGTCCTTACCCATGACTTTATCATACGGGAGAT
ATGGGGGGTTTATACCGAAGAAAGCCATACCCTCCGTGTGAATATGGCAAACATCCGAAGAAAGATAGAAGCAAACCCCG
GAGCGCCCCAGTATATCCTTACAGAAATGGGCGTTGGATACCGGATGGCGGAAGAAGTAACGGAAGGATAA

Protein sequence :
MEIKPTVLIIEDEDAICNFISAILSSNGYQVVKAKTGKEGLSLFTSHVPDLILLDLGLPDIDGIEILKNLRQWSKTPVIV
VSARGYEREKVAALDFGADDYIVKPFGTSELLARIRTAMRHSPQAAGTEVWGEEKVTIGKLAIDYGKRTVYKAGEKIHLT
PIEYKLLVLLSKNAGKVLTHDFIIREIWGVYTEESHTLRVNMANIRRKIEANPGAPQYILTEMGVGYRMAEEVTEG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
EF0571 NP_814337.1 DNA-binding response regulator Not tested Not named Protein 2e-45 50
ef0091 AAM75294.1 EF0091 Not tested Not named Protein 1e-45 50
SH0031 YP_251946.1 hypothetical protein Not tested SCCmec Protein 3e-28 42
kdpE YP_039536.1 response regulator protein Not tested Type-II SCCmec Protein 1e-27 41
kdpE NP_370594.1 transcriptional regulator kdpE Not tested Type-II SCCmec Protein 1e-27 41
kdpE NP_373306.1 hypothetical protein Not tested Type-II SCCmec Protein 1e-27 41
kdeP YP_190033.1 DNA-binding response regulator KdeP Not tested Type-II SCCmec Protein 1e-27 41
kdpE BAA82188.1 KDP operon transcriptional regulatory protein KdpE Not tested Type-II SCCmec Protein 7e-28 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_010079.5776364.p0 Protein 8e-23 42
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_002952.2859858.p0 Protein 8e-23 42
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_007622.3794948.p0 Protein 8e-23 42
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_003923.1003417.p0 Protein 8e-23 42
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_013450.8614146.p0 Protein 8e-23 42
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_002951.3238224.p0 Protein 8e-23 42
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_007793.3914065.p0 Protein 8e-23 42
Closa_4110 YP_003824241.1 winged helix family two component transcriptional regulator NC_002758.1121390.p0 Protein 8e-23 42