Gene Information

Name : hsdR_1 (HMPREF0659_A6116)
Accession : YP_003814183.1
Strain :
Genome accession: NC_014370
Putative virulence/resistance : Unknown
Product : type I site-specific deoxyribonuclease, HsdR family
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0610
EC number : 3.1.21.3
Position : 1410458 - 1413553 bp
Length : 3096 bp
Strand : -
Note : identified by match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM TIGR00348

DNA sequence :
ATGCCCTTCACAGAAGATAATTACGAAAAAGCACTGATATCCCTCTTTGAGGGAATGGGCTATCAATATTTGTACGGTCC
AAATATTGAAAGAGACTACTATGTGCCATATTATGAAGCACAATTAGAAGAAAGTCTGCAAACTGTTAATCCAAAGAAGC
CACATGCAGCCATTCACGAAGCGATTATCAAACTACGCAATATTGATATGGGTAGTTTGGCGCAGCGTAATGAAACTTTT
ACAGACTATTTGCAGCATGGCATAGAAGTTTCTTATTTCAATGGCAAGGAAATGCGCAATGAAATGGTCTATTTGATAGA
CTTTGAGCATACGGAAAAAAATACTTTTCAAGTCATCAACCAATGGACATTCATTGAAAATGCAGAAAAACGTGCCGATA
TCATTGTATTTGTGAATGGTTTACCATTGGTGGTTGTAGAATTAAAATCCCCTTCTCGTGAAGAAACAGATGCTTCAGAA
GCATATCTTCAACTCCGCAATTATATGAAAGATATACCATCGTTGTTCGCTTTCAATATGTTCTGTGTAATGAGCGATAT
GGCTCTTTCCAAAGCTGGAACAATTACTAGCAAGGAAGATCGCTACATGGAATGGAAAACAAAAGATGGCAATTATGAAA
GTACGGAATTTATCGATTATGATACCTTTTTTGAAGGAATATTTCAAAGGGAACGACTCTTAGACATAATCAAGAACTTT
ATCTGTTTTGCCAAAGAAGAAAAAGGGAGTGCCAAGATATTAGCAGGGTATCATCAGTATTTTGCAGTGAAGAAAGCCAT
CGAACGTACCAAACATGCTACAGTAAGTAATGGTAAAATCGGTGTGTTCTGGCATACGCAAGGCAGCGGTAAATCATTGT
CAATGGTTTTCTACGCCCACTTGCTGCAACAAGAGTTATCACAGCCCACAATAGTTGTGATTACCGACCGCAATGATTTG
GACGATCAACTTTATACCCAATTCTCTAAATGTAAGGAGTTCTTGCGTCAAACACCAGTGCAAGCCAATAGTCGTGAGAA
TCTAAAAGAGCTATTGAGTGGACGAGAAGCTAATGGCATTATCTTCACAACCATGCAGAAATTTGAGGAGTCTGACGAAC
CTTTGTCAGAGCGAAGAAATATTATCGTAATGACTGATGAGGCACATAGAGGACAATATGGCTTTGAGGAAAAAGTCGAT
GCCACTACAGGTAAGGTCTCTATCGGCACGGCAAGAATCATTCACAATTCACTACCCAATGCTTCATATATTGGCTTTAC
TGGTACACCTATCTCTACTAAAGACCGAGATACCGTAGAGGTTTTTGGTGATTATATTGATATTTATGACATGACGCAGG
CGGTTAATGACGGTGCTACTTGTCCTGTATATTATGAATCGAGAGTTATTAATCTAAATCTTGACGATGCAACCTTGCAA
GCCCTTGATGACGAATACGAGCTGTTGGCTGAAGAAGGTGCAACGACAGAACAGATAGAGAAAAGCAAGAAGGAGATGTC
GCACTTGGAAGAGATACTCGGTGCACCAGCTACCATCGATTCTCTTTGCCAAGACATTCTCAAACACTATGAGGAAAACC
GCCAATATGAATTGACAGGTAAGGCCATGATAGTAGCATATTCGCGTCCCATAGCCATGAGCATTTATCATCGACTGTTG
GAGCTTCGCCCAACTTGGACAGATAAAGTAAAAGTTGTCATGACGGGCAGCAACCAAGACCCAGAAGAATGGCACGACAT
TATCGGAAACAAGCAGTATAAGAAAGAACTTGCCAGACGATTTAAGGATGACAATGACCCGATGAAGATTGCTATTGTGG
TCGATATGTGGCTCACAGGCTTCGACGTTCCCTCATTGGCAACTATGTATGTTTACAAACCAATGAGCGGACATAACCTA
ATGCAAGCCATTGCGCGAGTGAACCGCGTATTCAATGGCAAAGTGGGTGGATTGGTTGTTGACTATATCGGTATTGCCAA
GGCCTTGAAAGAAGCCATGCGTGATTATACGGGGCGCGACAGAAAGAACTTTGGAAACCCAGATATCAAAGGCATGGCTT
TTACAAAGTTCAAAGAGAAGTTGGAAGTGTGCCAAGACTTATTTCATGGTTATAATTATAGTAGGTTCCACACAGGGACA
GATGCTGACCGTGCTAAATTAATCAAAGGTGGTGTAAACTTCATGTTGGCAACCGATAAACAAGAACAGTTACCGCTCTA
TATGAAAGAAGCAGCATTGCTGCACAATTCCATAACTCTTTGCCGAAGCCTGTTGAATAAAGAGCAACGCTTCTTGGCTG
CATTCTTTGAGACTGTACGCACTTTACTCTCCCGAATGACAGGCAAAGGAAAAGTTACGAAGAAAGAAATCAATGCTCGT
ATTAGCGAGTTGCTGAAACAAAGTGTAAAAAGTGAAGGTGTAATCAATCTTTTCTCTGATGTTAAAGCCGAGTTCTCCCT
CTTTGATACAGCCTTCTTAGATGAAATTTCTAAGATGAAAGAAAAAAATATAGCTGTAGAACTGCTTAAAAAGTTATTAG
CAGAGAAAGTGGCACTCTATCAAAAGACCAATATCGTGCAGTCAGAGAAATTCTCTGACCTGCTCAATCGTTCTTTATCC
AACTATTTGAAAGGATTACTCACCAATGAAGAAGTTATCCAAGAACTTTTGCAGTTAGCAAAAGAGATTGCTTCAGCCGA
TTCAGCAGCTAATGAACTTGGACTCACTCCTGAAGAAAAGTCATTCTATGATGCCTTGACCAAACCGCAAGCAATCCACG
ACTTCTATAGTAATGAAGAACTGGTTGCCATGACAAAAGAACTTACTGACTCTCTACGTAAGAACCGCACTATTGATTGG
CAAAAGAAAGAATCAGCCCGTGCCGGTATGCGCAGAATGATTAAACATCTTCTGAAAAAATATCATTACCCACCAGAGGA
AGCTGCCAATGCATTAGAAACTGTCATTAAGCAATGCGAGCAGTGGACGGATAATGGACAAGATAATTATACAACTCACA
CAGCCAAGATGTATGAAATTTATGAAGATGAAATACAGATGGCTGCAGAACCATAA

Protein sequence :
MPFTEDNYEKALISLFEGMGYQYLYGPNIERDYYVPYYEAQLEESLQTVNPKKPHAAIHEAIIKLRNIDMGSLAQRNETF
TDYLQHGIEVSYFNGKEMRNEMVYLIDFEHTEKNTFQVINQWTFIENAEKRADIIVFVNGLPLVVVELKSPSREETDASE
AYLQLRNYMKDIPSLFAFNMFCVMSDMALSKAGTITSKEDRYMEWKTKDGNYESTEFIDYDTFFEGIFQRERLLDIIKNF
ICFAKEEKGSAKILAGYHQYFAVKKAIERTKHATVSNGKIGVFWHTQGSGKSLSMVFYAHLLQQELSQPTIVVITDRNDL
DDQLYTQFSKCKEFLRQTPVQANSRENLKELLSGREANGIIFTTMQKFEESDEPLSERRNIIVMTDEAHRGQYGFEEKVD
ATTGKVSIGTARIIHNSLPNASYIGFTGTPISTKDRDTVEVFGDYIDIYDMTQAVNDGATCPVYYESRVINLNLDDATLQ
ALDDEYELLAEEGATTEQIEKSKKEMSHLEEILGAPATIDSLCQDILKHYEENRQYELTGKAMIVAYSRPIAMSIYHRLL
ELRPTWTDKVKVVMTGSNQDPEEWHDIIGNKQYKKELARRFKDDNDPMKIAIVVDMWLTGFDVPSLATMYVYKPMSGHNL
MQAIARVNRVFNGKVGGLVVDYIGIAKALKEAMRDYTGRDRKNFGNPDIKGMAFTKFKEKLEVCQDLFHGYNYSRFHTGT
DADRAKLIKGGVNFMLATDKQEQLPLYMKEAALLHNSITLCRSLLNKEQRFLAAFFETVRTLLSRMTGKGKVTKKEINAR
ISELLKQSVKSEGVINLFSDVKAEFSLFDTAFLDEISKMKEKNIAVELLKKLLAEKVALYQKTNIVQSEKFSDLLNRSLS
NYLKGLLTNEEVIQELLQLAKEIASADSAANELGLTPEEKSFYDALTKPQAIHDFYSNEELVAMTKELTDSLRKNRTIDW
QKKESARAGMRRMIKHLLKKYHYPPEEAANALETVIKQCEQWTDNGQDNYTTHTAKMYEIYEDEIQMAAEP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdR YP_251977.1 type I restriction-modification system restriction subunit Not tested SCCmec Protein 0.0 41
hsdR BAD24840.1 type I restriction-modification system endonuclease homologue Not tested Type-V SCCmec Protein 0.0 41
hsdR BAH57699.1 type I restriction-modification system endonuclease homologue Not tested Type-VII SCCmec Protein 0.0 41