Gene Information

Name : Spirs_0929 (Spirs_0929)
Accession : YP_003802657.1
Strain : Spirochaeta smaragdinae DSM 11293
Genome accession: NC_014364
Putative virulence/resistance : Virulence
Product : ATP-dependent chaperone ClpB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 982074 - 984668 bp
Length : 2595 bp
Strand : +
Note : COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR018368:IPR001270:IPR004176:IPR003959:IPR 013093:IPR019489:IPR003593:IPR017730; KEGG: bhy:BHWA1_00583 ATP-dependent Clp protease ATP-binding subunit ClpB; PFAM: ATPase AAA; Clp do

DNA sequence :
ATGCGATACGAAAACATGACGGTAAAGGTACAAGAGGCGTTTCAGGAGGCCGACTCCATCGCCCGGGACTACAATCATTC
AACTATTGAACCGGAACACTTTTTACTGGCCCTGCTGCGGCAGAAGGATGGTGTCGTGCCGCCTCTTCTCGACAGGCTTG
GGGCCGATAGAGGAGCCATAGAAGCCGATGTGCAGGAGGCTCTCGAATCAAAGCCCAGGGCCTACGGGAGTGCTTCCCAG
ATTACCCTTTCTGCGGAGATGGGGAATATCCTCCACAAGGCGGAGCAGGAATCAAAGGGGCTGAAAGACCAATATGTAAG
TGCTGAACACATCCTCCTGGCGATGCTATCCGTGGGAGGGAACGCTGCCGACTTGCTTGGGCGACAGGGGGTTACCCGGG
ACAGAACCTTCGAGGCTCTTCGTGCCGTCCGCGGAAATCAGCGTGTGACCGACCAGAATCCCGAGGAGCGGTATCAGGTC
CTTGATAAGTATTGTAAGGACCTCACGGCCCTTGCCAGGAGAGAGAAGCTTGATCCAGTCATCGGAAGGGACGAAGAGAT
TCGTCGGGTAATGCAGGTTTTAAGTCGGCGGACAAAGAACAACCCCGTGCTGATCGGTGAACCGGGGGTCGGAAAAACCG
CTATTGCCGAGGGCCTTGCCCGAAGGATCGTTTCCGGTGATGTCCCCGATTCTCTTAAAAACAAACGTCTGCTTGCCCTC
GACCTTGGAGCTCTTATTGCCGGGGCTAAGTTCAGAGGAGAGTTTGAAGAGCGTCTTAAGGCCGTTATTCATGAGATAGG
AGAGTCCGACGGTCAGATTATTCTCTTCATCGATGAGCTTCACACCCTTGTCGGCGCGGGAGCTGCCGAAGGTTCCACCG
ATGCGAGTAACCTTCTCAAGCCTGCCCTTGCCCGGGGAGAATTGCGGGCAATTGGTGCCACGACCCTGGATGAGTACCGA
AAGCATATCGAGAAAGACCCTGCGTTGGAACGCCGTTTTCAGCCGGTAATGACCAGCGAGCCTTCGGTGGAAAGCACCAT
CGCCATTCTCAGGGGACTTCAGGAGCGCTACGAGGTGCATCACGGGGTCAGGATCAAGGATGAGGCGCTGATCGCTGCGG
CCACCCTTTCGGACCGCTACATCACCAGCCGTTTCCTGCCCGATAAGGCGATAGACCTTGTCGACGAGGCTGCCAGCAGG
CTCAAGATGGAGATCGAGAGTCAGCCCATCGAACTCGACAAGATCGAGCGGAAGATTCTGCAGCTCAATATCGAGCGACA
GGCCCTGGTTCGGGAGGATGATGAGGCAAGTAAGGAGCGGTTGGAAAAGCTTGACCGCGAGCTGGCCGATTTAAAGAGCG
GTAGAGACGCCATGCGGCTTCAGTGGAACAATGAAAAAAAGGTGATCGATGGTATTCGAGAGCTGAAAAGTCGTCTCGAA
CAGTACAAAAGCGATGAGGTCCGTTTCGAACGGGACGGGAATCTTACCGGTGCCGCAGAGATAAAACACGGTAAGATACC
GGAAATCAAGCATCAGATCGAGGAAAAAAGCGCCGAGCTTGCAAAAATGCAGGGCCAAAGCGCACTGCTCCGTGAAGAGG
TTACCGAAGAAGATATTGCCGAGGTTGTCTCAACCTGGACCGGTATTCCCGTCAGTAAGATGCTTGCAAGCGAGATGGCA
AAGTATCTCCAGCTGGAATCGACCCTGGAAAAGCGGGTGGTCGGCCAGAAGGAGGCTATCCGTGCCGTCAGTGATGCCAT
CAGGCGGAACAAGACCGGTCTCTCCGATGAGGCAAGGCCTCTTGGTTCCTTTATCTTCATCGGCCCGACGGGGGTTGGAA
AGACCGAACTTGCCAGGACTCTTGCCGATTTTCTCTTTGACGACGAGCGCGCCCTTACCAGAATCGACATGAGTGAATAT
ATGGAAAAGCATGCGGTCAGTCGTCTTATCGGAGCGCCTCCTGGCTATGTCGGCTACGACCAGGGGGGGCAACTTACCGA
GGCGGTGAGAAGACGCCCCTACTCGGTGGTCTTGTTCGACGAAATCGAAAAGGCCCATCCCGATGTTTTCAACATCATGC
TTCAGCTTCTGGATGATGGAAGGCTGACCGACGGCCAGGGGCGTCTGGTTGATTTTCGCAACGCCATCATCATCATGACC
AGTAATATCGGAAGCGACCTTATTCTTCAGGCTGCAGACGGCGACGAGATCAATGAAAAGGTACATCAGCTGATGCGTGC
CACCTTTAAGCCCGAATTCCTCAACCGGGTCGATGAGATCATCACCTTCCACCGCTTAGGCAAGGAGGAGATTCTCTCTA
TTGTCGATATTCAGCTCGAGCGGCTCGAGCGGCGGCTTGCTTCGCAGCATATCTCGCTTGTGCTGAAGCCTAAGGCGAAG
GAGCTTCTTGCCTCCCTTGGCTATGATCCCGCATTTGGTGCCCGCCCGGTAAAGCGGACCATCCAGAATCTGCTTCAGAA
CCAGCTGGCAAAGATGATGCTTGCAGGGGAGATCCAGGACGGCGGCGGAGTCGAGGTTTCGGCCTCGGGGGGAAACCTCA
CCTTTAAACCCTTTGCACCGGCACCGAAGGTCTAA

Protein sequence :
MRYENMTVKVQEAFQEADSIARDYNHSTIEPEHFLLALLRQKDGVVPPLLDRLGADRGAIEADVQEALESKPRAYGSASQ
ITLSAEMGNILHKAEQESKGLKDQYVSAEHILLAMLSVGGNAADLLGRQGVTRDRTFEALRAVRGNQRVTDQNPEERYQV
LDKYCKDLTALARREKLDPVIGRDEEIRRVMQVLSRRTKNNPVLIGEPGVGKTAIAEGLARRIVSGDVPDSLKNKRLLAL
DLGALIAGAKFRGEFEERLKAVIHEIGESDGQIILFIDELHTLVGAGAAEGSTDASNLLKPALARGELRAIGATTLDEYR
KHIEKDPALERRFQPVMTSEPSVESTIAILRGLQERYEVHHGVRIKDEALIAAATLSDRYITSRFLPDKAIDLVDEAASR
LKMEIESQPIELDKIERKILQLNIERQALVREDDEASKERLEKLDRELADLKSGRDAMRLQWNNEKKVIDGIRELKSRLE
QYKSDEVRFERDGNLTGAAEIKHGKIPEIKHQIEEKSAELAKMQGQSALLREEVTEEDIAEVVSTWTGIPVSKMLASEMA
KYLQLESTLEKRVVGQKEAIRAVSDAIRRNKTGLSDEARPLGSFIFIGPTGVGKTELARTLADFLFDDERALTRIDMSEY
MEKHAVSRLIGAPPGYVGYDQGGQLTEAVRRRPYSVVLFDEIEKAHPDVFNIMLQLLDDGRLTDGQGRLVDFRNAIIIMT
SNIGSDLILQAADGDEINEKVHQLMRATFKPEFLNRVDEIITFHRLGKEEILSIVDIQLERLERRLASQHISLVLKPKAK
ELLASLGYDPAFGARPVKRTIQNLLQNQLAKMMLAGEIQDGGGVEVSASGGNLTFKPFAPAPKV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 3e-107 43
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 2e-107 43
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-106 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Spirs_0929 YP_003802657.1 ATP-dependent chaperone ClpB VFG2084 Protein 1e-114 45
Spirs_0929 YP_003802657.1 ATP-dependent chaperone ClpB VFG0079 Protein 1e-154 44
Spirs_0929 YP_003802657.1 ATP-dependent chaperone ClpB VFG2076 Protein 2e-118 41