Gene Information

Name : Spirs_0059 (Spirs_0059)
Accession : YP_003801813.1
Strain : Spirochaeta smaragdinae DSM 11293
Genome accession: NC_014364
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 65000 - 66766 bp
Length : 1767 bp
Strand : +
Note : COGs: COG0469 pyruvate kinase; InterPro IPR015793:IPR001697:IPR015794:IPR018209; KEGG: pth:PTH_2214 pyruvate kinase; PFAM: pyruvate kinase barrel; pyruvate kinase alpha/beta; PRIAM: pyruvate kinase; SPTR: pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: p

DNA sequence :
TTGAAATACCTAAGAAAGACCAGAATTGTGGCGACGATAGGTCCTGCCTGTGATGATCTTGCGATACAGAAGGAACTTCT
CAAAGCGGGGGTAAATGTTGCCAGGTTCAATTTTTCTCATGGTAATCACGAGGAGCAAGCCAAACGGATAGCATCGATGA
GGCGTGCTTCGGAGGAGACTTCTGTTCCCGTTGCCCTGATGATGGATACGAAGGGACCGGAAATCCGGACTGGGAATGTC
AAGGGCGAAGCTGAGCTTGCCTTACACAGCGGCTTTGAAATCGTATTGACCTCCCGTCACGTTGAGGGGACCAGAGAAGA
GCTGTCGGTGAGTTATCAGAATCTACCCTCCGAGGTCGAGGCTGGGGATCATATTTTTATTGCAGATGGGGTTATCGATT
TGGAAGTCCTTGCGGTCTCAGGTCCTGATATTCGTTGTTTGATTCGTAACGGCGGAATGCTTGGCAGCAAGAAAAACGTG
AATGTTCCTGGCGTAAAGGTTGGTTTGCCGGCTATCACGGAGAAAGACCGTGAGGACATTCGTTTTGCGGTCGAGCATCA
GATGGACTACATTGCAGCCAGTTTTATCAGAAGGCCTGAAGATGTTGAAGAAATTCGTGAGATTCTCAAACAATACCATT
CTTCTATCCGTATCATTGCAAAGATAGAGAACCAGGAAGGCCTTGATAATATTGACGACATCATTCGGATTTCCGACGGA
GTGATGGTTGCAAGAGGGGATCTTGGGGTACAGCTTTCAACGGAACAAATTCCTCTGGCCCAGAAACGGATCATTGGAAA
GTGCATGAGGCAAGGGAAGCCCGTTATTACCGCCACCCAGATGCTTGATTCTATGATTCACAATCCGAGCCCTACCAGGG
CAGAATTAACCGATGTTGCAAACGCTATTTTTGACGGAACCGATGCTGTCATGCTTTCTGGCGAGACAGCAGGCGGTGCG
TTTCCTGTACGGTCGGTTGAAACCATGGGACGCATTGCCGAGGCTGTCGAAACGAGTGAGGAGTATCGACGGCGGTGCAC
CCAATGGTTTGAAACCGTACAACGTCCGAAAGATATAGGTCATACCATTGCACGGGCCGCTTATGTTGTTGCATCCGATA
TTGATGCTTCCGCAATTGTCGCTCCGACGCTTCGGGGAAATACTCCTCGAATTCTGAGCAACTATCGACCGAACCAGCTC
ATTATTGCCGTCACCACCTCTGAGGAAAGCTATCGTCAGCTTCTTCTTCATTGGGGAATTTTTCCGATTTTATCTGCTCC
GGTGAAAGATTCCGACATGATGATCCAGAATGCCTTGAGGCTTGCACGTGAGCATGGGTATGTGGCCCCTCCTGATCGTG
TGGTTACCACGGCGGGGATTCCTCTTAACTCTCCTCAACCCCTCAATACGATCAAGATCCATTTTCTTGGGACGATCCTA
AATAGAGGTCATGCCGGTATGGGGGATCGCTGTTCCGGGGCTCTTGTTAAGGCTGAAAATTTTGAACTTGCCCAGCATCG
TCTTCGCTGGGATGGAACCGAGATTTTGTTGACCGGCTCCATAGGGAAAGAGCTTTTCCCTCGCCTTTCCTCTTTGCGAG
GAATTGTTATAGAGGGGGAGCTTTCCCTATCTCCCGAGGAGGTTCGCAAGATCGCTTCTAAGATTGTAATCATAGCCGAT
GTCCCTAACGCCATGGACAATTTTGAGGATGGGCAGCTGGTGACTCTTGATGGCAAAGAGAAGATCATTTACGAAGGCTT
TATGTGA

Protein sequence :
MKYLRKTRIVATIGPACDDLAIQKELLKAGVNVARFNFSHGNHEEQAKRIASMRRASEETSVPVALMMDTKGPEIRTGNV
KGEAELALHSGFEIVLTSRHVEGTREELSVSYQNLPSEVEAGDHIFIADGVIDLEVLAVSGPDIRCLIRNGGMLGSKKNV
NVPGVKVGLPAITEKDREDIRFAVEHQMDYIAASFIRRPEDVEEIREILKQYHSSIRIIAKIENQEGLDNIDDIIRISDG
VMVARGDLGVQLSTEQIPLAQKRIIGKCMRQGKPVITATQMLDSMIHNPSPTRAELTDVANAIFDGTDAVMLSGETAGGA
FPVRSVETMGRIAEAVETSEEYRRRCTQWFETVQRPKDIGHTIARAAYVVASDIDASAIVAPTLRGNTPRILSNYRPNQL
IIAVTTSEESYRQLLLHWGIFPILSAPVKDSDMMIQNALRLAREHGYVAPPDRVVTTAGIPLNSPQPLNTIKIHFLGTIL
NRGHAGMGDRCSGALVKAENFELAQHRLRWDGTEILLTGSIGKELFPRLSSLRGIVIEGELSLSPEEVRKIASKIVIIAD
VPNAMDNFEDGQLVTLDGKEKIIYEGFM

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 8e-79 43
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 8e-79 43
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-78 43
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 2e-78 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Spirs_0059 YP_003801813.1 pyruvate kinase VFG0479 Protein 4e-79 43