Gene Information

Name : Spirs_0494 (Spirs_0494)
Accession : YP_003802235.1
Strain : Spirochaeta smaragdinae DSM 11293
Genome accession: NC_014364
Putative virulence/resistance : Virulence
Product : Fis family transcriptional regulator
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG2204
EC number : -
Position : 509028 - 510341 bp
Length : 1314 bp
Strand : -
Note : COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterProIPR001789:IPR003593:IPR020441:IPR002078:IPR 002197; KEGG: aoe:Clos_1079 two component, sigma54 specific, Fis family transcriptional regulator;

DNA sequence : 
ATGTATACCATACTTCTTGTTGATGATGAAAAAAACCTGCGGACATCAATAGCGCACTTTTTTTCCCTTGAAGGCATAGA
AACCGAAGAGGCAAGCAACGGTCTTGCCGCTCAGCAGCTTCTCATGAAACACCACTTTGACGCGGTCATCACCGATCTGA
AGATGCCAGGGATGAACGGACTCGAACTCTTGGAGTGGATCGGTGAAAGCGGCCCCGATATCCCGGTTTTTATGATCTCC
GCCTTTGGAGAGGTGGAAGATGCCGTCCAGGCAATGAAGAAGGGGGCCGTCGACTATGTAGTAAAGCCCTTCGATCCCGA
AGAACTTATCCTTCGGTTGAGAAGAGAGCTGGAGCGGCGAAAGCTTCAGAAGCTTACCAACACGATACCCACCGACGATG
ATTACACCGGGGAGAGTCCTGCCATGCGACAGCTTTTTTCTCTGGCGAGAAAGGTGGCACCGACGGCCTCAAATGTTCTC
ATTACCGGTGAAAGCGGCACAGGAAAAGAGGTAATGGCCCGTTTCCTCCATAATCATTCCGATCGCAGCAAGAACAATTT
TCAGGCGGTCAATCTTGGAGGAATACCCGAGAGCCTCATGGAAAGTGAGTTGTTCGGCTATGAAAAAGGGTCCTTTACCG
GAGCGGATCACAGAAAAATTGGTTATTTTGAAGCTTCAAATGGGGGGACCATCTTTCTCGACGAGGTAGGTGAAGCGCCT
CTCGCCCTTCAAGTAAAGCTATTGAGGGTACTTCAGGAAAAAGCCGTCACGCGGGTGGGCGGTACCGGTACAATCCCTCT
TGATATCAGAATCATCGCCGCCACAAACAAGGATCTTGATGCAATGGTAAAGGCGCGCGACTTCAGAGATGACCTCTACT
ATCGGCTGAACGTCATCCATCTCCAGCTTCCTGCCCTGAGGGAACGACGTGAAGATATTCCATTTCTGGCCGAGACCTTT
CGCAGCAAATTTGCCTCATCCATGGGAAAAACAATCACGGGTTTCTCCGACGATGCAATGAAAGCGCTGCAACACTATTC
TTTTCCCGGGAATATTCGAGAGTTGGAAAATATGGTCGAACGAGCGATGATCCTTGCAGAGCCACCGCTGCTGGAACGTA
AGGATTTCCCCCTTCATCAGGAAGAAGGGCCCCAAACTCCCAAAGGCAGTCTTCGAGAACTGGAGCGAGAAGCGATTCTG
GAAGCCCTTCTGAGAAATAACGGACACAGGGAAAAAAGTGCCGCAGAACTGGGCATCACCCGCAGAACGCTTCTGAACAA
AATCAACGAGTACGGGATTTCAATCCCGGAATGA

Protein sequence : 
MYTILLVDDEKNLRTSIAHFFSLEGIETEEASNGLAAQQLLMKHHFDAVITDLKMPGMNGLELLEWIGESGPDIPVFMIS
AFGEVEDAVQAMKKGAVDYVVKPFDPEELILRLRRELERRKLQKLTNTIPTDDDYTGESPAMRQLFSLARKVAPTASNVL
ITGESGTGKEVMARFLHNHSDRSKNNFQAVNLGGIPESLMESELFGYEKGSFTGADHRKIGYFEASNGGTIFLDEVGEAP
LALQVKLLRVLQEKAVTRVGGTGTIPLDIRIIAATNKDLDAMVKARDFRDDLYYRLNVIHLQLPALRERREDIPFLAETF
RSKFASSMGKTITGFSDDAMKALQHYSFPGNIRELENMVERAMILAEPPLLERKDFPLHQEEGPQTPKGSLRELEREAIL
EALLRNNGHREKSAAELGITRRTLLNKINEYGISIPE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00300 YP_008207765.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Not tested AbaR25 Protein 1e-58 41
BJAB0868_00304 YP_008211630.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Not tested AbaR26 Protein 1e-58 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Spirs_0494 YP_003802235.1 Fis family transcriptional regulator BAC0089 Protein 7e-72 43
Spirs_0494 YP_003802235.1 Fis family transcriptional regulator BAC0467 Protein 3e-74 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Spirs_0494 YP_003802235.1 Fis family transcriptional regulator VFG1214 Protein 5e-73 46
Spirs_0494 YP_003802235.1 Fis family transcriptional regulator VFG1249 Protein 1e-72 45
Spirs_0494 YP_003802235.1 Fis family transcriptional regulator VFG0116 Protein 6e-63 43