Gene Information

Name : Spirs_2638 (Spirs_2638)
Accession : YP_003804341.1
Strain : Spirochaeta smaragdinae DSM 11293
Genome accession: NC_014364
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.3
Position : 2820594 - 2822075 bp
Length : 1482 bp
Strand : -
Note : COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160:IPR015590; KEGG: ele:Elen_1838 aldehyde dehydrogenase; PFAM: aldehyde dehydrogenase; SPTR: aldehyde dehydrogenase (NAD+); PFAM: aldehyde dehydrogenase family

DNA sequence : 
ATGAACATGCCGAGACCAATGGATGAAAAGTACAAGATGCTGATCGGAGGCCAATGGGTGGAAGCCTCGAACGGGAAAAC
TTGTACTGCGTACTGCCCTGCCAACGGAGAGGTTCTTGCTACCTTTCCCGACGCCAGTAAAGAGGATGTCGACAAGGCGG
TGAAGGCTGCATGGAAGGCCTTCGACGGCTGGAAAAAAATCAGCCCGCAGGAACGATCGGCGCTTTTGCTTAAGATTGCC
GATCTGATCGACGCCAACCTCGATAAGTTGGCAATGATTGAAACGCTGGACAACGGTAAACCGATCCGTGAGACTTTTGG
AATCGATGTTCCCCTCGGTTCCGATCATTTCCGCTATTTCGCCGGTGCTATTCGCGCGGAAGAGGGACAGGCGGTGATGA
TCGACGATCAGACCATGAGCATCATTCTCCGTGAGCCCATCGGAGTGGTCGGGCAGATCATACCTTGGAATTTCCCTTTT
ACGATGGCTGCCTGGAAGATTGCTCCTGCTCTTGCGGCGGGGTGCTGTGTCGTGATTAAGCCCTCAAGTTCAACCTCTCT
CAGTATGCTTGAGTTTGCAAAGCTGGTCAACGACGTACTGCCTCCCGGGGTACTCAATGTCGTTACCGGCAGGGGCTCTC
AGGCCGGACAGTTCCTCCTTGATCATAAAGATCTCAGAAAATTAGCGTTTACTGGTTCAACGGAGGTTGGGTATCAGGTC
GCCGATGCCGCAGCCAAGAAGTTGATTCCTGCAACCTTGGAATTGGGTGGAAAATCTGCAAACATTTTCTTCCCCGATGC
TCCATGGGATAAGGCCATCGAAGGCGTTCAGATGGGGATACTGTTCAACCAGGGACAAGTCTGCTGTGCCGGTTCCCGTG
TCTTCGTTCATGAGGATATTTACGACAAGTTCCTCGCCCAGCTCGTTAAAGCCTTTAACAGCATCAAGGTGGGGATGCCG
TGGGAGAAAGATACCGTCATGGGCTCCCAGATCGATCAGAATCAGCTCGATAAAATCCTCGCCTATGTACATATCGGAGA
AAAGGAGGGGGCAAAGATTGCCTGCGGCGGAACACGGGCAGAGGGTAATGGCCTTGAAAACGGTGCCTTTATGAAGCCAA
CCATGCTTGTGGATGTAAAGAATAGCATGAGGGTCGCTCAGGAAGAGATCTTCGGACCGGTTGCCGCCGTAATCAAGTTT
AAGAGCGAGCAGGAAGTCATTGATATGGCAAACGACAGCGAATATGGTCTCGGCGGTGCCGTTTGGACAAAGGATATCAA
TCGTGCTTTCCGGGTCGCCCGCGCCGTGGAAACAGGACGTATGTGGGTAAATAACTATAATAATCTTCCTGCCCATGCCC
CCTTTGGAGGGTACAAGAAGTCGGGTATCGGGCGTGAGACCCACAAAGTGATACTCGATCACTACACGCAGATGAAAAAC
ATCTATATCAGCATGACCGAAGAGCCCTTCGGCCTCTATTGA

Protein sequence : 
MNMPRPMDEKYKMLIGGQWVEASNGKTCTAYCPANGEVLATFPDASKEDVDKAVKAAWKAFDGWKKISPQERSALLLKIA
DLIDANLDKLAMIETLDNGKPIRETFGIDVPLGSDHFRYFAGAIRAEEGQAVMIDDQTMSIILREPIGVVGQIIPWNFPF
TMAAWKIAPALAAGCCVVIKPSSSTSLSMLEFAKLVNDVLPPGVLNVVTGRGSQAGQFLLDHKDLRKLAFTGSTEVGYQV
ADAAAKKLIPATLELGGKSANIFFPDAPWDKAIEGVQMGILFNQGQVCCAGSRVFVHEDIYDKFLAQLVKAFNSIKVGMP
WEKDTVMGSQIDQNQLDKILAYVHIGEKEGAKIACGGTRAEGNGLENGAFMKPTMLVDVKNSMRVAQEEIFGPVAAVIKF
KSEQEVIDMANDSEYGLGGAVWTKDINRAFRVARAVETGRMWVNNYNNLPAHAPFGGYKKSGIGRETHKVILDHYTQMKN
IYISMTEEPFGLY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-101 53
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 8e-104 51
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 8e-104 51
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 8e-104 51
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-103 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Spirs_2638 YP_003804341.1 aldehyde dehydrogenase VFG0082 Protein 7e-102 53