Gene Information

Name : pykA (NIDE4286)
Accession : YP_003799873.1
Strain : Candidatus Nitrospira defluvii
Genome accession: NC_014355
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 4219042 - 4220493 bp
Length : 1452 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10751408, 12798932, 1447787, 1859631, 20179818, 2379684, 7549104, 8074528, 8274531, 8366023, 8436141, 8591049; Product type e : enzyme

DNA sequence :
ATGCGAAAAGCGAAAATCGTCTGCACCATTGGTCCGGCGAGCGATGGCGTCGTTGTGCTCGAGCAGCTCATTCGAAGCGG
CATGGATGCAGCCCGTTTGAATTTTTCCCACGGCACGCACGACTCGCATGGGCGAGCGATCAAGACGATTCGCGACACGG
CCGATCGCCACGGGGTGGCGATTGCGATCATCCAGGACCTGCAGGGGCCGCGCATTCGCGTCGGCGAGATCGACGGCGCG
CTGGAGCTCATCGCCGGTCAGCGAGTTCGGCTGAGGACGATGTCCTTGCGATCCGGCGGGCAGATCGGCGCCAGGACGGT
GCTCGCCACGGGTACGGTGCAGGATATCCCTGTCACCTATCAGGCGCTGACCAGGGACATTCGGCCAGGGGCAAAAATAC
TCATCGATGACGGTTTGGTGGAATTGACGGCGGATCGAATCGTGGATGGTGCGGTAGAGTGTACCGTGGTGGCAGGCGGA
CGTGTGACGTCTCATAAGGGTATGAATCTGCCCGGCACGGTCGTGAGCGCTCCGACCCTGACGGAGAAAGACCGGGACGA
TGTGCGTTTCGGCGTGGCGCAGGGCGTGGACTATATCGCGTTATCCTTTGTCCGTGGAGCGCAGGACATCATGGCCGCCA
AGGAATTGATTGCCGAATGCGGCGGCGACGTGCCGGTGATCGCCAAGATCGAGCGGCAGGAGGCGGTGACGGACCTGGAG
GCCATTCTCGCCCATGCCGACGGGGTCATGGTGGCGCGCGGAGATTTGGGCGTTGAACTCGGCCCGGAAGCCGTGCCGGT
GTTGCAGAAGCGCATCATCGCGACGGCCAATCGCCAACGACGGCTGGTGATCACCGCGACGCAGATGCTCGAGTCCATGA
CGCAACATCTGCGGCCGACCAGGGCGGAAGCGTCGGATGTGGCCAATGCCGTGTTCGACGGCACCGATGCCGTGATGCTC
TCCGCGGAAACGGCCGTCGGCCATTACCCGGTGGAAGTCGTGCAGGTGATGGATCGGATCATCCGGGCGGCCGAAGTCGA
AACGGGGCCCTGTTTTGTCCGTCGCTCGCAGGGCGAGCAGGGGCAGGACTCTATTCCGGAAGCCATCTCGCTGTCGGCCT
ATTCAGCGGCGGCGACGATCGGCGCGAGTGCGATCGTCGCCTTCAGTGAACGGGGGACCACGGCCCGGCTGGTTTCCAAG
CAACGTCCGGTTGCGCCGATCATCGCGTTGACGCCGTTCGAGACGGTCCGCCGGCAGATGGCGTTGTATTGGGGGGTCCT
TCCCCGCACCGTGCCGCAGATTCCAACGACCGATGAGCGGGTCAACGAGGCTGAGCGGTGCTTGAAGGCCGAGGGACTGG
CACGGAGCGGGCAACGGATCGTCATTTTGTCGGGCACCAGAATCGGACAGCCGGGCGGGACGAATCTGATGAAATTGCAT
GAGGTGGCGTAG

Protein sequence :
MRKAKIVCTIGPASDGVVVLEQLIRSGMDAARLNFSHGTHDSHGRAIKTIRDTADRHGVAIAIIQDLQGPRIRVGEIDGA
LELIAGQRVRLRTMSLRSGGQIGARTVLATGTVQDIPVTYQALTRDIRPGAKILIDDGLVELTADRIVDGAVECTVVAGG
RVTSHKGMNLPGTVVSAPTLTEKDRDDVRFGVAQGVDYIALSFVRGAQDIMAAKELIAECGGDVPVIAKIERQEAVTDLE
AILAHADGVMVARGDLGVELGPEAVPVLQKRIIATANRQRRLVITATQMLESMTQHLRPTRAEASDVANAVFDGTDAVML
SAETAVGHYPVEVVQVMDRIIRAAEVETGPCFVRRSQGEQGQDSIPEAISLSAYSAAATIGASAIVAFSERGTTARLVSK
QRPVAPIIALTPFETVRRQMALYWGVLPRTVPQIPTTDERVNEAERCLKAEGLARSGQRIVILSGTRIGQPGGTNLMKLH
EVA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 1e-61 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 4e-70 41
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 4e-70 41
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 3e-70 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA YP_003799873.1 pyruvate kinase VFG0479 Protein 2e-70 41