Gene Information

Name : guaA (NIDE1422)
Accession : YP_003797097.1
Strain : Candidatus Nitrospira defluvii
Genome accession: NC_014355
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1365870 - 1367426 bp
Length : 1557 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10387030, 10856643, 1312531, 1736096, 189701, 4353875, 4591951, 6119351, 8548458; Product type e : enzyme

DNA sequence :
ATGGAACTCTGGCACGATAGAATTCTCGTCCTCGATTTCGGATCCCAGTACACGCAGTTGATCGCACGCCGTATTCGTGA
AGCGCAGGTCTATTCGCAGATCCTGCCCTGCACCGTGCCGCTTGCGACGGTATTGGCCTACCGTCCGAAGGGTATTGTGT
TATCCGGCGGACCATCGAGCGTGTACGACAAGAAGGCGCCTTCTGTCTCCAAGCAACTCTTCGAACAGGGCATTCCCATT
CTCGGGATCTGCTACGGAATGCAGCTGGTGACGCATCTGCAGGGGGGCGAAGTGGAGAAGGCTCCGCACCGCGAGTTCGG
CCGAGCTGAACTGACCCTCGATGACCGGTCGGATCTGTTCAAGGGAATCGGAACTCGTGGCTCGACCGTCGTGTGGATGT
CGCACGGGGATCGTATCGAACGGATGCCGCCGGGTTTCCGTTCCATCGCACACACGGAGAATTCTCCCATCGCCGCAATG
AAGCGGCACGACGCCAAGCAGCGCATCTACTGTCTTCAATTTCATCCGGAAGTGGCGCACACCGTCGAGGGCGCCACGAT
CCTCAAGAACTTCGTCTACGATATTTGCGGCTGCAAGCCGACCTGGACCATGCGTTCCTATGTTGAAACAGCCGTGGAAC
AAATCAGGCAACAAGTCGGGACGGAGCGGGTGATCTGCGCCTTGAGCGGCGGGGTGGATTCCTCTGTGGCAGCGGCCCTT
ACGCACCGTGCGGTCGGCGATCAACTGACCTGCGTTTTTGTCGACAATGGGGTGTTGCGTACCGGTGAACGTGACCAGGT
CGAGAAAACCTTCGCGTCGCAGATGCATCTGAACATGCGGATCCTCGATCGCACCAGTCAATTTCTCACGGGCCTGAAGA
ACGTGACCGACCCCGAGCGGAAGCGAAAGATTATCGGTCGTCTCTTCATCAAAAATTTTGAGGTGGAGTCCAAAAAGTTG
AAGGGCATCAAATACCTCGTGCAAGGCACGTTGTATCCCGATGTCATCGAAAGCGTGAGCTTCAAGGGCCCTTCGGCGAC
GATCAAAACGCACCACAACGTCGGGGGATTGCCGACCAGAATGAAGTTGAAGCTGGTCGAGCCCCTGCGTGAATTGTTCA
AGGACGAAGTGCGGGTCTTGGGGCAGGAGCTCGGCCTGCCGGATGAGATTATCTGGCGGCAACCCTTTCCCGGTCCCGGC
CTGGCGATCCGCGTGCTCGGCGCAGTCACCAAGGAACGGTTGGCGATTCTGCGCGGGGCGGAAACGATCGTCGATCAGGA
AATTCGAGCCGCCGGCCTGTATCGGGAGATCTGGCAGGCATTCGCCGTCCTGCTGCCGATCCGGACGGTCGGTGTCATGG
GTGACCAGCGGACGTATGAATATGTCATTGCCATCCGCGCGGTCACGAGCCTCGATGGCATGACCGCCGACTGGGCCAAG
ATCCCGAACGAGGTGCTGGGGAAAATGTCGAGCCGGATCATCAACGAAGTGAAGGGCGTGAATCGCGTCGTCTACGACAT
CAGTTCCAAGCCGCCTTCCACGATCGAGTGGGAGTAA

Protein sequence :
MELWHDRILVLDFGSQYTQLIARRIREAQVYSQILPCTVPLATVLAYRPKGIVLSGGPSSVYDKKAPSVSKQLFEQGIPI
LGICYGMQLVTHLQGGEVEKAPHREFGRAELTLDDRSDLFKGIGTRGSTVVWMSHGDRIERMPPGFRSIAHTENSPIAAM
KRHDAKQRIYCLQFHPEVAHTVEGATILKNFVYDICGCKPTWTMRSYVETAVEQIRQQVGTERVICALSGGVDSSVAAAL
THRAVGDQLTCVFVDNGVLRTGERDQVEKTFASQMHLNMRILDRTSQFLTGLKNVTDPERKRKIIGRLFIKNFEVESKKL
KGIKYLVQGTLYPDVIESVSFKGPSATIKTHHNVGGLPTRMKLKLVEPLRELFKDEVRVLGQELGLPDEIIWRQPFPGPG
LAIRVLGAVTKERLAILRGAETIVDQEIRAAGLYREIWQAFAVLLPIRTVGVMGDQRTYEYVIAIRAVTSLDGMTADWAK
IPNEVLGKMSSRIINEVKGVNRVVYDISSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-141 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-141 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-141 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-126 52