Gene Information

Name : tlyB (BP951000_1802)
Accession : YP_003786283.1
Strain : Brachyspira pilosicoli 95/1000
Genome accession: NC_014330
Putative virulence/resistance : Virulence
Product : hemolysin B
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 1966343 - 1968790 bp
Length : 2448 bp
Strand : +
Note : -

DNA sequence :
GTGGAAGAAGCTAAGAGATTAAATCATGATATGCTTACTCCAGAGCATGTTTTATTAGGAATATTTCATGAAACTGATTC
AATAGTTGTGAATGTTTTAAATAAATTAAAAATAGATATAGAAAAAATTAAATTTGATATAGAATCTTCTATGGTAAAAT
CTACAAGCAACACTAAATTGTTTGGTAAGATACCTCCATCACCACGCATTCAGCATTTAATAAGCAGAGCGGCAGAAGAG
GCTAAATCATTAGGAGATAATTGCATAAGCACAGAACATTTACTTCTTGGTATTTTAAAAGAGGAAAATGGAATAGCATA
TAATGTACTTACTAGCTATAATTTAGATTTAAAAACATTAAGACATGAGATGATGAGAATTAGAGGTAAATCTGGTTCTT
CATCAAATATTTCTGAATCTTCTTCTAGCACTATTCAAGAAGATAACACAGCAAGAACTCCTACTTTAGATAAGTTTGCA
CGTGATTTAACTAAAATGGCTAGAGAAAAGGCTTTAGATAGAGTGATAGGCAGAGAAAACGAGGTAATGAGAGTTGTACA
GATACTTTCAAGGAGAAAGAAAAATAACCCTATACTATTAGGAGAGCCTGGTGTTGGTAAGACTGCTATAGTTGAGGGGT
TGGCTGAAAAGATTGTTTCTACTGATGTGCCTGATATATTATTAAAAAAGAGAGTTTTGAGTTTAGATTTATCTTCTGTT
GTTGCTGGTACTAAATATAGAGGTGAGTTTGAAGAGAGAATAAAAAACATAGTAATGGAGATAAAGAAAGTTGGCAATAT
TATAATATTTATAGATGAGCTTCATACTTTAATTGGAGCAGGAGGAGCAGAGGGAGCTTTAGATGCTGCTAATATGCTTA
AGCCTGCACTTTCACGCGGAGAGATTCAATGTATTGGGGCTACTACAATTAATGAATATAAAAAGTATATAGAAAAAGAT
GGTGCTTTGGTGAGAAGATTTCAGCCTATAAATGTTGAAGAGCCTTCTATTGAAGATACTATAGAAATATTAAATGGAAT
AAAATCTAAATATGAAGAGCATCATAAAGTAAAATATACTGATGGGGCTATTTATGCTTCTGCTGTATTAAGTAAAAGAT
ATATATTTGAAAGACATTTACCAGATAAGGCTATAGATTTAATTGATGAGGCAGGTTCGAGAGCAAGACTTATGAATATG
GTAAGACCTCAGGAATTAAAAGATTTAGAAAATAAAATAAAAGAGCTTAATCAAGAAAAAGAGACTGTTGTAAAAAATCA
GAATTTTGAAGAGGCTGTTAAATTAAGAGATGCTATAAAATCTTTACAAGAGGAATTGGATAAAAAAGAAGCTGAGTGGA
GAAGCGAAAGAGACAAAACAGAAACAATTATTAATGAAGATGATATAAGACATGTAATATCAGAAATTACAAATATACCA
GTAAAAAGATTATTAGATTCTGAGAGTAAAAGACTTATTGGTATGGAAGATGAACTTCACAGTAAGATAGTAGGTCAGAA
AGAGGCTATATCATCTATATCAAAAGCTATAAGAAGAGCAAGAGCCGGATTAAAAAGCACTAAAAAACCGCTTGGAAGTT
TTATATTTTTAGGTCCTACTGGTGTTGGTAAAACTGCTTTAGCTAAAGTACTTTCAGAGTTTATGTTTGGAGATAGTGAT
GCTCTTATAAGAATAGATATGAGTGAGTTTATGGAGAAGTTTGCAGTAAGCAGACTTATTGGAGCTCCTCCTGGATATGT
TGGATATGAAGAGGGAGGCGGACTTACAGAGAAGGTGAGAAGAAAACCTTATTCTTTAATACTTTTTGATGAGATAGAAA
AAGCTCACCCCGACATCACAAACATACTTTTACAGGTGCTTGAAGAGGGGCAGCTTACAGATAACTTTGGAAGAAAGGTT
GATTTCTCTAATACTATAATTATTATAACAAGCAACTTGGGTGCAAGAGATATTGTTAAAGGAACTTCTTTAGGTTTTAA
TGCCATTGGAAGTGAAAAAGATATTAATGACATGAAAAACTTTGCTATGGAAGAATTGAAGCAGAATTTCAATCCAGAGT
TTTTAAACAGAATAGATGATATTATAGTATTCCATACTCTTACAAAAGAAGATTTGAAAGATATTATAGAGATTATGCTT
AGAGAGTTGAATGAAGCTATAAAAGATAGAAATATTTTTATAAGTTTAACTGATGATGCAAAAAATTATATAATAGATAA
AGGCTTTGACAAGAAATATGGTGCAAGAAGTTTAAGACGTGCTATACAAAAAGAGGTTGAAGATTATATTAGTACAGAGA
TACTTTTCGGGCATATTGAAGAGGGCGATAATATAAATGTTGATTCTGATGGGCAGTCGCTGCTATTTAATGTTGAAAAG
GTAAAGACCTACAGAGAAAATGAGGTAGAAGAGTTATCTAAGAGTTGA

Protein sequence :
MEEAKRLNHDMLTPEHVLLGIFHETDSIVVNVLNKLKIDIEKIKFDIESSMVKSTSNTKLFGKIPPSPRIQHLISRAAEE
AKSLGDNCISTEHLLLGILKEENGIAYNVLTSYNLDLKTLRHEMMRIRGKSGSSSNISESSSSTIQEDNTARTPTLDKFA
RDLTKMAREKALDRVIGRENEVMRVVQILSRRKKNNPILLGEPGVGKTAIVEGLAEKIVSTDVPDILLKKRVLSLDLSSV
VAGTKYRGEFEERIKNIVMEIKKVGNIIIFIDELHTLIGAGGAEGALDAANMLKPALSRGEIQCIGATTINEYKKYIEKD
GALVRRFQPINVEEPSIEDTIEILNGIKSKYEEHHKVKYTDGAIYASAVLSKRYIFERHLPDKAIDLIDEAGSRARLMNM
VRPQELKDLENKIKELNQEKETVVKNQNFEEAVKLRDAIKSLQEELDKKEAEWRSERDKTETIINEDDIRHVISEITNIP
VKRLLDSESKRLIGMEDELHSKIVGQKEAISSISKAIRRARAGLKSTKKPLGSFIFLGPTGVGKTALAKVLSEFMFGDSD
ALIRIDMSEFMEKFAVSRLIGAPPGYVGYEEGGGLTEKVRRKPYSLILFDEIEKAHPDITNILLQVLEEGQLTDNFGRKV
DFSNTIIIITSNLGARDIVKGTSLGFNAIGSEKDINDMKNFAMEELKQNFNPEFLNRIDDIIVFHTLTKEDLKDIIEIML
RELNEAIKDRNIFISLTDDAKNYIIDKGFDKKYGARSLRRAIQKEVEDYISTEILFGHIEEGDNINVDSDGQSLLFNVEK
VKTYRENEVEELSKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tlyB YP_003786283.1 hemolysin B VFG0079 Protein 0.0 52
tlyB YP_003786283.1 hemolysin B VFG0080 Protein 5e-143 51