Gene Information

Name : cagA (HPB8_741)
Accession : YP_003728762.1
Strain : Helicobacter pylori B8
Genome accession: NC_014256
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : S : Function unknown
COG ID : COG4372
EC number : -
Position : 716816 - 720370 bp
Length : 3555 bp
Strand : +
Note : Cytotoxicity-associated immunodominant antigen (120 kDa protein) (CAG pathogenicity island protein 26), CagA exotoxin

DNA sequence : 
ATGACTAACGAAACCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
GGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGGATA
ACAGGCAAGCTTTTGAGAAAATCTCGCAGCTAAGGGAGAAATTCGCTAATAAAGCGATCAAAAATCCTACCAAAAAGAAT
CAGTATTTTTCAAACTTTATCAGTAAGAGCAGTGATTTAATCAACAAAGACGGTCTCATTGATACAGGTTCTTCCATAAA
AAGCTTTCAGAAATTTGGGACTCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAGATCCATCTCAAATCA
ACACCCAAAAAATCCGAGGTTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAGAAAGCGGAGTTTTTG
AGGTCTGCCAAACAAGCTCTTGCAGGAATTATCATAAGAAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTTTGA
TGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTAATGGAGATCCTACTGGTGGGGATTGGTTTGATA
TTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAACCAGTTCCTCATGTC
CAACCAGATGTAGCCACTACCACCACTGACATACAAAGCTTACCGCCTGAATCTAGAGATTTACTTGATGAAAGGGGTAA
TTTTTCTAAATTCACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGAGTCGCTGACATTGATCCCAATTACAAGTTCA
ACCAATTATTGGTTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATGATGGCATAGAACCTGAAAAAGTTTCA
TTATTGTATGGAAACAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTCATAAAAACCAACAAGGCAA
CAATGTGGCTACACTCATTAATGTGCATATGAAAAACGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGGTTAACA
ACCCTAGTTTTTATCTCTACAAAGAAGATCAGCTCACAGGCTTGAAACAAGCATTGAGTCAAAAAGAGATCCAAAACAAA
GTAGATTTCATGGAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCAAGAAAGAGAAAGAAAAATTCCAAAA
TGAGATTGAAGATTTTCAAAAAGACCATAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAA
AAGACAAAAAACATTTAGCTTTAGTTACTGAGTTTGGTAGTGGGGACTTGAGCTACACTCTCAAAGATTATGGGAAAAAA
GCAGATAAAGCTTTAGATAGGGAGATAAAAACCACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTA
TTCTAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTGGAAG
CAAATCTTAGCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTTATATAAGGCGAGACTTA
GAAGAGAAACTGGGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAGGA
ATTGGTTGGAAAAGTTTTAAACCTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAAAAG
CTCAGAAAAATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGTGAAAAAATTGGAGAACAGAAAC
GACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCAATTATCAATGAAGAGGC
TAGTAAGGAAGCAAGAGTGGCCGCTTGCGTTCAGAAGTTTAAAGGCATCAAAATGGAATTGTCTGATAAGTTTGAAAACA
TCAACAAGAATTTGAAAGACTTTGATAAATCTTTTGATGACTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAA
GAAACGCTAAAAGCCCTTAAAGGCTCGGTGAAGGATTTAGGCATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAA
TACAGCTTTGAATGACTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATT
CCATTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAAGCGGTATCAGTGGCTAAAGCA
ACAGGCGATTTCAGTGGGGTAGAGCAAGCGCTAGCCGATCTCAAGAATTTCTCAAAAGGACAATTGGCTCAACAAGCTCA
AAAAAATGAAGATTTCAATACTGGAAAAAATTCTGAACTATACCAATCCGTTAAGAATGGTGTAAATGGAACCCTAGTCG
GTAATGGGTTATCTGGAATAGAGGCCACAGCTCTCACCAAAAATTTTTCGGATATCAAGAAAGAATTGAATGAGAAATTT
AAAAATTTCAATAACAATAATAATGGTCTCAAAAACAGCGGAGAACCCATTTATGCTCAGGTTAATAAAAAGAAAACAGG
ACAAGTAGCTAGCCCTGAGGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAAAGCAAAAATTGACCAATTCAATCAAG
TAGCAAGTGGTTTGGGTGGTGTAGGGCAAGCGGGATTCTCTTTGAAAGGGCATACTAAAGTTGATGATCTCAGTAAGGTA
GGGCGATCAGTTAGCCCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAA
AGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGAATCAAGAATTGGCTCAGAAAATTGACAATCTCAATCAGGCGGTAT
CAGAAGCTAAAGCATGTCATTTTGACAACCTAGATCAAATGATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATG
AATCTATATGTTGAAAGTGCAAAAAAAGTGCCTACTAGTTTGTCAGCGAAATTGGACAATTATGCTATTAACAGCCACAC
ACGCATTAATAGCAATGTCAAAAATGGAACAATCAATGAAAAAGTGACCGGCATGCTAACGCAAAAAAACCCTGAGTGGC
TCAAGCTCGTGAATGATAAGATAGTTGCACATAATGTGGGAAGCGTTCCTTTGTCAGAGTATGATAAAATTGGCTTCAAC
CAGAAAAATATGAAAGATTATTCTGATTCATTCAAGTTTTCCACCAGGTTGAGCAATGCTGTAAAAGACATTAAGTCTGG
CTTTGTGCAATTTTTAACCAATACATTTTCTATGGGATCTTACAGCTTGATGAAAGCAAGTGTGGAACATGGAGTCAAAA
ATACTAATACAAAAGGTGGTTTCCAAAAATCTTAA

Protein sequence : 
MTNETINQQPQTEAAFNPQQFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREKFANKAIKNPTKKN
QYFSNFISKSSDLINKDGLIDTGSSIKSFQKFGTQRYQIFMNWVSHQKDPSQINTQKIRGFMENIIQPPISDDKEKAEFL
RSAKQALAGIIIRNQIRSDQKFMGVFDESLKERQEAEKNGEPNGDPTGGDWFDIFLSFVFNKKQSSDLKETLNQEPVPHV
QPDVATTTTDIQSLPPESRDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLVHNNALSSVLMGSHDGIEPEKVS
LLYGNNGGPEARHDWNATVGHKNQQGNNVATLINVHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQALSQKEIQNK
VDFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDHKAYLDALGNDHIAFVSKKDKKHLALVTEFGSGDLSYTLKDYGKK
ADKALDREIKTTLQGSLKHDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEANLSKVAVFNLPNLNNLAITSYIRRDL
EEKLGAKGLSPQEANKLIKDFLNSNKELVGKVLNLNKAVAEAKNTGNYDEVKKAQKNLEKSLRKREHLEKEVVKKLENRN
DNKNRMEAKAQANSQKDKIFAIINEEASKEARVAACVQKFKGIKMELSDKFENINKNLKDFDKSFDDFKNGKNKDFSKAE
ETLKALKGSVKDLGINPEWISKVENLNTALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSVAKA
TGDFSGVEQALADLKNFSKGQLAQQAQKNEDFNTGKNSELYQSVKNGVNGTLVGNGLSGIEATALTKNFSDIKKELNEKF
KNFNNNNNGLKNSGEPIYAQVNKKKTGQVASPEEPIYTQVAKKVKAKIDQFNQVASGLGGVGQAGFSLKGHTKVDDLSKV
GRSVSPEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSRNQELAQKIDNLNQAVSEAKACHFDNLDQMIDKLKDSTKKNVM
NLYVESAKKVPTSLSAKLDNYAINSHTRINSNVKNGTINEKVTGMLTQKNPEWLKLVNDKIVAHNVGSVPLSEYDKIGFN
QKNMKDYSDSFKFSTRLSNAVKDIKSGFVQFLTNTFSMGSYSLMKASVEHGVKNTNTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 100
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 98
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 94
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 90
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 90
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 90
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 90
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 90
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 89
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 88
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 87
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 86
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 86
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 86
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 85
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 84
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 83
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 83
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 82
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 81
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 81
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 81
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 80
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 76

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_003728762.1 cytotoxin-associated protein A VFG0306 Protein 0.0 86