Gene Information

Name : metB (HPB8_1459)
Accession : YP_003729480.1
Strain : Helicobacter pylori B8
Genome accession: NC_014256
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1428637 - 1429779 bp
Length : 1143 bp
Strand : +
Note : 4.4.1.8] [KO:K01739 K01760], synonyms: O-succinylhomoserine (thiol)-lyase, CGS, metC

DNA sequence :
ATGCGCATGCAAACAAAACTAATCCATGGGGGCATTAGTGAGGATACGACAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCATAAGGGCTATGAATACTCTCGCTCAGGCAACCCCACACGCTTTG
CTTTAGAAGAACTCATCGCTGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGACTAGCTGGAATCCACGCC
GTTTTTTCCCTCTTGCAATCAGGCGATCATGTGTTGTTGGGCGATGATGTCTATGGGGGGACTTTCCGCTTGTTCAATAA
AGTGCTTGTCAAAAACGGGCTTTCTTGCACCATTATAGACACTAGCGATCTATCCCAAATCAAAAAGGCTATCAAGCCCA
ACACCAAAGCCCTTTATTTAGAAACCCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGCGCAATGCGCTAGTGTCGCT
AAAGATCATGGTCTGCTCACTATCGTGGATAACACCTTTGCCACCCCCTATTATCAAAACCCGCTTCTTTTGGGAGCGGA
CATTGTGGTGCATAGCGGCACAAAATACTTAGGCGGGCATAGCGATGTGGTTGCTGGGCTTGTAACCACCAATAATGAAG
CGCTAGCCCAAGAGATCGCCTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTGGGATTGCGCATGGAAGCTCATCAAAAAAACGCCTTTTGCGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTGGAAAGGGTTTATTACCCAGGCCTGCCCACCCACCCTAATTACGAGCTAGCCAAAGCCCAAATGCGTGGCTTTA
GCGGGATGCTCTCTTTCACTCTCAAAAATGACAGCGAGGCGGTTGCTTTTGTAGAAAGCCTTAAACTATTCATTTTAGGC
GAAAGTTTGGGCGGGGTGGAAAGTTTGGTGGGGATTCCAGCATTTATGACCCATGCGTGCATCCCTAAAGAACAACGAGA
AGCTGCAGGGATTAGAGATGGTTTGGTGCGCTTGTCTGTAGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAGGCTAA

Protein sequence :
MRMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNAFCVAEFLEKHPKVERVYYPGLPTHPNYELAKAQMRGFSGMLSFTLKNDSEAVAFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-97 55
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-99 55
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-73 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_003729480.1 cystathionine gamma-synthase BAC0207 Protein 8e-64 44