Gene Information

Name : lysS (HMPREF0837_10997)
Accession : YP_003724439.1
Strain : Streptococcus pneumoniae TCH8431/19A
Genome accession: NC_014251
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 917640 - 919130 bp
Length : 1491 bp
Strand : +
Note : COG: COG1190; Pfam: PF01336,PF00152; InterPro: IPR002313

DNA sequence :
ATGTCTACAGAACATATGGAAGAACTAAATGACCAGCAGATCGTTCGCCGTGAAAAAATGGCTGCGCTCCGCGAACAAGG
AATCGATCCTTTCGGAAAACGTTTTGAACGTACTGCAAATTCACAAGAATTAAAAGATAAATATGCCAACCTCGATAAAG
AACAATTACACGATAAAAACGAAACAGCTACTATCGCAGGACGCTTGATAACCAAACGTGGTAAAGGAAAAGTTGGTTTT
GCCCACCTTCAAGACCGCGAAGGCCAGATTCAGATCTACGTTCGTAAGGATGCTGTCGGTGAAGAAAACTACGAAATCTT
CAAAAAAGCAGACCTTGGTGACTTCCTTGGTGTCGAAGGTGAAGTGATGCGTACGGATATGGGAGAACTCTCTATCAAGG
CAACCCACATCACACACTTGTCTAAGGCTCTTCGTCCTCTTCCTGAGAAATTCCATGGTTTGACAGACGTTGAAACAATT
TACCGTAAACGTTACCTTGACTTGATTTCTAACCGTGAAAGCTTTGAACGCTTTGTCACTCGTTCAAAAATCATCTCTGA
AATCCGTCGTTACCTTGACCAAAAAGGATTCCTTGAAGTGGAAACACCTGTTCTTCATAATGAAGCCGGTGGTGCTGCTG
CCCGTCCATTTATCACCCACCACAATGCCCAAAACATTGACATGGTGCTTCGTATCGCGACTGAGCTTCACTTAAAACGC
CTTATCGTGGGTGGTATGGAACGTGTCTATGAAATTGGCCGTATCTTCCGTAACGAAGGAATGGACGCTACTCATAACCC
TGAGTTTACTTCTATCGAAGTTTACCAAGCTTATGCAGACTTCCAAGACATCATGGACTTGACGGAAGGCATTATCCAAC
ACGCTGCTAAATCAGTTAAGGGCGATGGCCCAGTCAACTACCAAGGTACTGAAATCAAGATTAACGAACTATTTAAGCGT
GTTCATATGGTGGATGCTATCAGAGAAATTACTGGTGTCGATTTCTGGCAAGACATGACTTTAGAAGAAGCTAAAGCTAT
CGCTGCTGAGAAGAAAGTTCCAGTTGAGAAACACTACACTGAGGTTGGTCACATCATCAATGCCTTCTTTGAAGAGTTTG
TTGAAGAAACTTTAATCCAACCAACCTTTGTCTATGGACATCCAGTAGCTGTATCTCCACTCGCTAAGAAAAATCCTGAA
GACCAACGCTTTACTGACCGTTTCGAGCTCTTTATCATGACTAAGGAGTACGGTAATGCCTTTACTGAACTCAACGACCC
AATCGACCAACTTAGCCGTTTTGAAGCCCAAGCTAAAGCCAAAGAACTTGGTGATGATGAAGCGACAGGAATCGACTATG
ACTACATTGAAGCTCTTGAATACGGTATGCCACCAACAGGTGGTTTGGGAATCGGTATCGACCGTCTCTGCATGCTCCTC
ACTGATACAACAACTATCCGTGATGTATTGCTCTTCCCAACAATGAAATAA

Protein sequence :
MSTEHMEELNDQQIVRREKMAALREQGIDPFGKRFERTANSQELKDKYANLDKEQLHDKNETATIAGRLITKRGKGKVGF
AHLQDREGQIQIYVRKDAVGEENYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETI
YRKRYLDLISNRESFERFVTRSKIISEIRRYLDQKGFLEVETPVLHNEAGGAAARPFITHHNAQNIDMVLRIATELHLKR
LIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQAYADFQDIMDLTEGIIQHAAKSVKGDGPVNYQGTEIKINELFKR
VHMVDAIREITGVDFWQDMTLEEAKAIAAEKKVPVEKHYTEVGHIINAFFEEFVEETLIQPTFVYGHPVAVSPLAKKNPE
DQRFTDRFELFIMTKEYGNAFTELNDPIDQLSRFEAQAKAKELGDDEATGIDYDYIEALEYGMPPTGGLGIGIDRLCMLL
TDTTTIRDVLLFPTMK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 2e-106 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_003724439.1 lysyl-tRNA synthetase VFG1668 Protein 1e-106 46