Gene Information

Name : fliI (HMPREF0573_10867)
Accession : YP_003718680.1
Strain : Mobiluncus curtisii ATCC 43063
Genome accession: NC_014246
Putative virulence/resistance : Virulence
Product : H(+)-transporting two-sector ATPase
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.14
Position : 1004011 - 1005345 bp
Length : 1335 bp
Strand : +
Note : COG: COG1157; Pfam: PF02874,PF00006; InterPro: IPR005714

DNA sequence :
GTGAGCGCCTTGGAGCTGGCTACTTTACCATCTTTCGTGAGTCTGCTGAATGCCTCACGTCCGCAGCGGGTCGGCGAGGT
GGAATCCGTCGTGGGCTTGTCTGTCCGGGTTCGCGGTTTGCAGTGCTCTGTAGGTGAAGTCGTGCTGGTGGGGGACGACC
CCGGTGTCCCCGCCGAAGTGGTGGCGCTGGATGCGGGTATCGCCTCGTGTATGCCTCTGGATAACCTGGACGGTCTGCGG
GTCGGTTCCCCGGTGCGCGGTACCGGCTTACCTGCCACAGTTCCGGTCGGTCCGGCTCTGCTGGGACGGGTTATCGACGC
TGCCGGACGCCCGCTGGATGGCAAAGGTCCGATTTATGCGGCTGACCGGGTACCGATTCATGGAGCGGCTCCCAATGCTT
TGGAACGTGCCCGGATTGATATGCCGGTCGCGATGGGGGTGCGTGTCCTGGACACGCTGGTGACGTTAGGGCGCGGTCAG
CGCATCGGCTTGTTTGCTGGTTCCGGGGTCGGTAAATCGACATTGATGTCGATGATTGCACGTGGCACGAATGCTGAAGT
GTGTGTGATTGCCCTGGTGGGTGAGCGTGGACGGGAAGTCCGTGAGTTCTTGGAAGATGATTTGGGCGAGGAGGGTTTGT
CCCGTTCGGTCGTGGTGGTGGCGACTTCGGATGAGTCCCCGATGCTGCGTAAACGCGCCGCCTTCACTGCCACCCGCGTC
GCCGAGTACTACCGGGATGCCGGTCGCCACGTCCTGCTGATGATGGATTCCCTGACCCGTACCTGTATGGCACAGCGCGA
AATTGGTCTCTCTGTAGGTGAACCGCCCGCTACTCGCGGCTATCCACCTTCGACTTTCTCGATGATGGCGCAATTGCTGG
AACGAGCAGGTTCCGGTGCTATCGGGTCTGTGACCGGCATTTACACCGTGCTTGTGGATGGGGATGACCATAATGAACCC
ATTGCTGACCAGGCACGTTCTATCCTGGATGGGCACGTCGTGCTGGATCGGAAACTGGCGGTGGCGGGACACTATCCGGC
TATCGACGCGCTGGGTTCTATCTCCAGGGTGGCATCCAAAGTCACGACGCGGGAGCAACGGGAAGCTGCAACCGCTTTGC
GTCAGATTATGGGGGCAAAACGTTCTGTGCAGGACTTGCTGGATGTGGGGGCTTACCAGGCGGGCACCAATCCCGAGGTG
GATACGGCAGTGAAATATGATGCCGAGATTGAAGCATTCCTGACGCAAAAGACTGACGAGAAGGTCGAATTCGACGCAGC
TTGGTCGCAACTGTTCGACCTCTATCAGGCTTTCAAGTCTGAGGAAGCGGCATAG

Protein sequence :
MSALELATLPSFVSLLNASRPQRVGEVESVVGLSVRVRGLQCSVGEVVLVGDDPGVPAEVVALDAGIASCMPLDNLDGLR
VGSPVRGTGLPATVPVGPALLGRVIDAAGRPLDGKGPIYAADRVPIHGAAPNALERARIDMPVAMGVRVLDTLVTLGRGQ
RIGLFAGSGVGKSTLMSMIARGTNAEVCVIALVGERGREVREFLEDDLGEEGLSRSVVVVATSDESPMLRKRAAFTATRV
AEYYRDAGRHVLLMMDSLTRTCMAQREIGLSVGEPPATRGYPPSTFSMMAQLLERAGSGAIGSVTGIYTVLVDGDDHNEP
IADQARSILDGHVVLDRKLAVAGHYPAIDALGSISRVASKVTTREQREAATALRQIMGAKRSVQDLLDVGAYQAGTNPEV
DTAVKYDAEIEAFLTQKTDEKVEFDAAWSQLFDLYQAFKSEEAA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-85 52
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-85 52
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 6e-84 51
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 6e-84 51
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 4e-84 51
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-83 51
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 8e-84 51
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 1e-82 51
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-82 51
lscN AAO18044.1 LscN Virulence TTSS locus Protein 3e-75 50
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 1e-69 49
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 7e-70 49
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 2e-68 48
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 5e-68 48
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 1e-62 47
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 1e-66 47
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 2e-73 47
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 5e-67 47
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 4e-67 47
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-71 47
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 1e-71 47
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 1e-70 47
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-70 47
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-71 47
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 2e-64 47
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 2e-64 47
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 2e-69 47
escN AAC38383.1 EscN Virulence LEE Protein 3e-72 46
escN YP_003236088.1 translocator EscN Virulence LEE Protein 7e-72 46
escN NP_290268.1 hypothetical protein Virulence LEE Protein 4e-72 46
ECs4568 NP_312595.1 EscN Virulence LEE Protein 4e-72 46
escN AAC31513.1 L0034 Virulence LEE Protein 3e-72 46
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 3e-72 46
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 5e-70 45
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 5e-70 45
escN YP_003223475.1 translocator EscN Virulence LEE Protein 7e-72 45
escN CAC81862.1 EscN protein Virulence LEE II Protein 7e-72 45
escN CAI43874.1 EscN protein Virulence LEE Protein 5e-72 45
invC AAS66861.1 InvC Not tested SSR-2 Protein 8e-62 45
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 3e-63 44
escN AAK26715.1 EscN Virulence LEE Protein 2e-71 44
escN AAL57542.1 EscN Virulence LEE Protein 2e-71 44
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 1e-71 44
unnamed AAL06369.1 EscN Virulence LEE Protein 1e-71 44
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 4e-62 44
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-57 44
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-57 44
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 1e-57 44
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-57 44
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 1e-60 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG0192 Protein 6e-81 52
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG0048 Protein 9e-84 50
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG1254 Protein 8e-81 50
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG0390 Protein 2e-78 49
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG2331 Protein 1e-80 49
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG2144 Protein 1e-80 48
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG0515 Protein 8e-72 47
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG0730 Protein 2e-72 46
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG0812 Protein 2e-72 46
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG0555 Protein 5e-58 44
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG2459 Protein 7e-61 42
fliI YP_003718680.1 H(+)-transporting two-sector ATPase VFG1778 Protein 1e-63 42