Gene Information

Name : HMPREF0573_11213 (HMPREF0573_11213)
Accession : YP_003719026.1
Strain : Mobiluncus curtisii ATCC 43063
Genome accession: NC_014246
Putative virulence/resistance : Resistance
Product : tetracycline resistance protein Tet
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0480
EC number : -
Position : 1420799 - 1422718 bp
Length : 1920 bp
Strand : +
Note : COG: COG0480; Pfam: PF00009,PF03144,PF03764,PF00679; InterPro: IPR000795

DNA sequence :
ATGAAAATAATTAACTTAGGCATTCTGGCTCACGTTGACGCAGGAAAGACAACATTAACGGAAAGTTTATTGTATACCAG
TGGTGCAATTGCAGAACTAGGGAGCGTAGATGAAGGCACAACAAGGACAGATACAATGAATTTGGAGCGTCAAAGGGGAA
TCACTATCCAGACAGCAGTGACATCTTTTCAGTGGGAGGATGTAAAAGTCAACATTATAGATACGCCAGGCCATATGGAT
TTTTTGGCGGAAGTATACCGTTCTTTATCCGTATTAGACGGAGCAGTATTATTAGTTTCTGCAAAGGATGGCATACAGGC
ACAGACCCGTATACTGTTTCATGCACTACAGATAATGAAGATTCCGACAATTTTTTTCATCAATAAAATTGACCAAGAGG
GGATTGATTTGCCAATGGTATATCGGGAAATGAAAGCAAAGCTTTCTTCGGAAATTATAGTGAAGCAAAAGGTTGGGCAG
CATCCCCATATAAATGTAACGGACAATGACGATATGGAACAGTGGGATGCGGTAATTATGGGAAACGATGAACTATTAGA
GAAATATATGTCAGGGAAACCGTTTAAAATGTCAGAACTGGAACAGGAAGAAAACAGGAGATTCCAAAACGGAACGTTAT
TTCCCGTTTATCACGGAAGCGCTAAAAACAATCTGGGGATTCGGCAGCTTATAGAAGTAATTGCCAGTAAATTTTATTCA
TCAACGCCTGAAGGTCAATCTGAACTATGCGGGCAGGTTTTTAAGATTGAATATTCAGAGAAAAGGCGGCGTTTTGTTTA
TGTGCGTATATATAGCGGAACATTGCATTTGAGGGATGTTATTAGAATATCTGAAAAAGAGAAAATAAAAATCACAGAGA
TGTGTGTTCCGACAAACGGTGAATTATATTCATCCGATACAGCCTGCTCTGGTGATATTGTAATTTTACCAAATGATGTT
TTGCAGCTAAACAGTATTTTGGGGAACGAAATACTGTTGCCGCAGAGAAAATTTATTGAAAATCCTCTCCCTATGCTCCA
AACAACGATTGCAGTAAAGAAATCTGAACAGCGGGAAATATTGCTTGGGGCACTTACAGAAATTTCAGATGGCGACCCTC
TTTTAAAATATTATGTGGATACTACAACGCATGAGATTATACTTTCTTTTTTGGGGAATGTGCAGATGGAAGTCATTTGT
GCCATCCTTGAGGAAAAATATCATGTGGAGGCAGAAATAAAAGAGCCTACTGTTATATATATGGAAAGACCGCTTAGAAA
AGCAGAATATACCATCCACATAGAAGTCCCGCCAAATCCTTTCTGGGCTTCTGTCGGGTTGTCCATAGAGCCGCTCCCTA
TTGGAAGCGGAGTGCAGTATGAAAGCAGAGTTTCACTTGGATATTTAAATCAATCGTTCCAAAATGCGGTTATGGAGGGG
GTTCTTTATGGCTGCGAGCAGGGGCTGTATGGATGGAAAGTGACAGACTGTAAAATCTGTTTTGAATATGGATTGTATTA
TAGTCCTGTAAGTACCCCCGCAGACTTTCGGCTGCTTTCCCCTATCGTATTGGAGCAGGCTTTAAAAAAAGCAGGGACAG
AACTATTAGAGCCATATCTCCACTTTGAAATTTATGCACCGCAGGAATATCTCTCACGGGCGTATCATGATGCTCCAAGG
TATTGTGCAGATATTGTAAGTACTCAGATAAAGAATGACGAGGTCATTCTGAAAGGAGAAATCCCTGCTAGATGTATTCA
AGAATACAGGAACGATTTAACTTATTTCACAAATGGGCAGGGAGTCTGCTTGACAGAGTTAAAAGGATACCAGCCAGCTA
TTGGTAAATTTATTTGCCAACCCCGCCGCCCGAATAGCCGTATAGATAAGGTTCGGCATATGTTCCACAAGTTAGCTTAA

Protein sequence :
MKIINLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTRTDTMNLERQRGITIQTAVTSFQWEDVKVNIIDTPGHMD
FLAEVYRSLSVLDGAVLLVSAKDGIQAQTRILFHALQIMKIPTIFFINKIDQEGIDLPMVYREMKAKLSSEIIVKQKVGQ
HPHINVTDNDDMEQWDAVIMGNDELLEKYMSGKPFKMSELEQEENRRFQNGTLFPVYHGSAKNNLGIRQLIEVIASKFYS
STPEGQSELCGQVFKIEYSEKRRRFVYVRIYSGTLHLRDVIRISEKEKIKITEMCVPTNGELYSSDTACSGDIVILPNDV
LQLNSILGNEILLPQRKFIENPLPMLQTTIAVKKSEQREILLGALTEISDGDPLLKYYVDTTTHEIILSFLGNVQMEVIC
AILEEKYHVEAEIKEPTVIYMERPLRKAEYTIHIEVPPNPFWASVGLSIEPLPIGSGVQYESRVSLGYLNQSFQNAVMEG
VLYGCEQGLYGWKVTDCKICFEYGLYYSPVSTPADFRLLSPIVLEQALKKAGTELLEPYLHFEIYAPQEYLSRAYHDAPR
YCADIVSTQIKNDEVILKGEIPARCIQEYRNDLTYFTNGQGVCLTELKGYQPAIGKFICQPRRPNSRIDKVRHMFHKLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tetO AFJ97266.1 truncated tetracycline resistant protein Not tested Not named Protein 0.0 99
SSU05_0922 YP_001198287.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 77
SSU98_0928 YP_001200485.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 77
tet(W) YP_005160006.1 tetracycline resistance protein Not tested Not named Protein 0.0 68

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet AJ295238.gene.p01 Protein 0.0 80
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet AM180355.1.gene636.p Protein 0.0 78
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet M85225.gene.p01 Protein 0.0 77
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet X04388.gene.p01 Protein 0.0 77
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet NC_002758.1120355.p0 Protein 0.0 76
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet NC_009782.5559075.p0 Protein 0.0 76
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet L09756.gene.p01 Protein 0.0 72
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet AY485126.gene.p01 Protein 0.0 70
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet AJ222769.gene.p01 Protein 0.0 68
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet FN594949.1.gene24.p0 Protein 0.0 68
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet DQ294299.gene.p01 Protein 0.0 67
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet AJ514254.gene.p01 Protein 1e-115 44
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet L42544.gene.p01 Protein 2e-118 44
HMPREF0573_11213 YP_003719026.1 tetracycline resistance protein Tet Z21523.gene.p01 Protein 7e-107 41