Gene Information

Name : Trad_1498 (Trad_1498)
Accession : YP_003705162.1
Strain : Truepera radiovictrix DSM 17093
Genome accession: NC_014221
Putative virulence/resistance : Resistance
Product : D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1052
EC number : -
Position : 1602209 - 1603207 bp
Length : 999 bp
Strand : +
Note : COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006140:IPR006139:IPR016040; KEGG: hoh:Hoch_1800 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding;

DNA sequence : 
ATGGACCTCGCCATCTTTAGCACCAAGCCTTACGACCGCCGCTTTTTCGAGGCCGCCAACGCCGAGCACGGCCACGGGCT
GCACTTTTTTGAGCCCCGCTTAACGCCGGAGACCGCTTCGCTCGCCGCCGGGTTTACGGGCGTGTGCGCTTTTGTCAACG
ACGTCTTAAGCGCGCCCGTCTTGCGCGAACTGGCCGCGGGCGGCACGAAGCTCATCGCGCTGCGCTCGGCGGGCTTTAAC
CACGTCGACTTGGGCGCGGCGCAGGAGCTGGGCCTCACCGTCGCCCGCGTGCCCGCCTACTCGCCTTACGCCGTCGCCGA
GCACGCGCTCGCTCTTATCCTCACCCTCAACCGCAAAACCCACCGCGCCTTTAACCGGGTGCGTGAGGGCAACTTCGCCC
TCGACGGGCTTTTGGGTTTTGACCTGCACGGCAAAACGGTCGGGGTGGTCGGCACCGGCAAGATCGGCCTCATCTTCGCG
CGGATCGCCGCGGGGTTTGGCTGCGAGGTGCTCGCCTACGACCCCTACCCGAACCCCGAGGCGCGCGCCCGCTACGTCCC
CCTCCCCGAGCTTTTGGGGGCCGCGGACATCGTCTCGCTCCACTGCCCGCTCACCCCCGAGACGTACCACCTCATCGGCA
AAGAGGCGGTCGCGCAGATGAAACCGGGGGCGATGCTGATCAACACGAGCCGCGGCGCGTTGGTCGACACGCGGGCGGTG
ATCCATGGGCTCAAGTCGGGGCAGATCGGCGCGCTCGGTCTAGACGTCTACGAGGAGGAGGCCGACCTCTTTTTCGAGGA
CCTCTCCGACCGGGTCATCCAAGACGACGTCTTTACCCGCCTGCTGACGTTTCCCAACGTGCTGATCACCGGCCACCAGG
GGTTTTTCACCGTCGAGGCGCTTGACAACATCGCCCACACGACGCTGCGCAACGTCACTGCCTTTGAGACGGGGGCGGGC
GAGCTGCACCGCGTCGCCGTCGACACCGCGCACGCGTAA

Protein sequence : 
MDLAIFSTKPYDRRFFEAANAEHGHGLHFFEPRLTPETASLAAGFTGVCAFVNDVLSAPVLRELAAGGTKLIALRSAGFN
HVDLGAAQELGLTVARVPAYSPYAVAEHALALILTLNRKTHRAFNRVREGNFALDGLLGFDLHGKTVGVVGTGKIGLIFA
RIAAGFGCEVLAYDPYPNPEARARYVPLPELLGAADIVSLHCPLTPETYHLIGKEAVAQMKPGAMLINTSRGALVDTRAV
IHGLKSGQIGALGLDVYEEEADLFFEDLSDRVIQDDVFTRLLTFPNVLITGHQGFFTVEALDNIAHTTLRNVTAFETGAG
ELHRVAVDTAHA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanHB YP_008394258.1 VanH protein, D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 4e-40 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Trad_1498 YP_003705162.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein AF310956.2.orf4.gene Protein 2e-40 43
Trad_1498 YP_003705162.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein AF155139.2.orf4.gene Protein 9e-39 43
Trad_1498 YP_003705162.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein NC_005054.2598279.p0 Protein 9e-37 41
Trad_1498 YP_003705162.1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein NC_014475.1.orf2.gen Protein 9e-37 41