Gene Information

Name : Arch_1062 (Arch_1062)
Accession : YP_003697395.1
Strain : Arcanobacterium haemolyticum DSM 20595
Genome accession: NC_014218
Putative virulence/resistance : Virulence
Product : thiol-activated cytolysin
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1197288 - 1198997 bp
Length : 1710 bp
Strand : -
Note : InterPro IPR001869; KEGG: ssb:SSUBM407_0558 suilysin (hemolysin); PFAM: thiol-activated cytolysin; SPTR: O31241 Pyolysin; PFAM: thiol-activated cytolysin

DNA sequence :
ATGACACGGAGATTTCTTGCAACGGTAGCAGGCACGGCATTGCTGGCAGGAGCATTCGCTCCCGGCGTTGCGTTTGGAGT
TGACGCTTCAACACAAACCGATCCAGTTTCGCCAACCTCTTCCGCAACTGAAACTGTCAATAGAAGCGATCAAACGGCAA
GTAATCCAACAGACAAGACCACACCAGCTCCCGCTGCACAGACTGGTGAATCCGCGCAAGATCCGAAGCCTGTTAAGCAA
AAAGATTTTCCTGCCGTAAAGACCCAGCCTGCACAAACTGTTGATAACGGTCGCGAAATTGATAAATTCATCAGATCTCT
AGACTACGATCCAGTTGGAGTTCTCGCAGTTCAAGGCGAGAAAATTGAGACGGTTCCGGTAACAAAAGAATCGTTTAAGA
ACGGAACGTACACCGTATTCAAGCATGAAAAGAAGACCTTCAATAATTTGCGAGGTGATATTTCGGTAATCGAGGCCAAT
AATGCCAATACGTTCCCAGGAGCGTTGGTCCGTGCTAATCAAAATCTCTCGAAAGGGAGTCCTACCGTAGTGGGAATTGA
TCGAGCACCTATTACCGTCAGTGTTGATCTTCCTGGGCTTTTGAGTGGTAAGGGAGAGAAAGTCATCCAGAATCCTCATA
AGAGTTCCGTCCAAGGTGGCATCAATGAGTTGTTGAAGGGGTGGACGGATATGCATTCTACTTACCCAAACCATGCAGCA
AAGATTTCATATGATGAGTTGATGGTCAATTCGAAAGAACAGCTTGAAGCTAAGTTTGGCCTTGGTTTTGAAAAGGTTGC
AAACAAGCTTGATGTTAACTTCGATGCGATCCACAAGCATGAGCGCCAAGTTGGCATTGCTTCCTTCAAGCAGATTTTCT
ACACGGTTTCTACTGATACTCCGAACAATCCTCACGAGCTGTTTGCAAAGAATGTAACGAAGCAAGATTTGATTGATCGC
AATATTGATAAAAAGAACCCGTTAGCCTACATTTCGAATGTAAGTTACGGCCGTCAGATCTTCGTGAAGCTGGAAACTGA
TTCCACTGATAATGATGTGAAGGCAGCATTTAGCGCAGTATTTAAGGGTAGCTTCGGTAATGGCAAGACAGATGTTGATA
CGAAGTACAAGAATATCTTGAATAAGACTCGCGCAACTGTCTATGTTCTTGGTGGAAGTGCGCAAAAGGGCGTTGAAGTT
GCGACAGGAAGCATTGAAGATCTCAAGAGGATTATCAAAGAAGAAAGCACCTTCTCGACCACCGTTCCAGCTGTGCCAGT
TTCCTACACAGTTAACTTTGTGAAGGACAACCAGCGTGCAGTAGTCAAGAACACTGGCGAGTACATTGAAACCACCGCAA
CTACCTACAACTCGGGCTTCATTACACTTCGTCACCGTGGCGGTTACGTTGCAAAGTTCGCTTTGGAATGGGATGAAATT
AGCTACGACGAGAAGGGCGTTCAGCACGTCAAGCCTGTGAAGTGGGCAGGAACATGGAAGGCTCGTACTCACGGTTTCCG
CGAACGCATCCAGATTCCAGCAAACGCACGTAACATTCACGTGAAGGCAGGTGAAGGTACTGGTTTGGCTTGGGATAAGT
GGTGGACAGTGATCGATGAACGGAACATTCCGTTGGTTAAGGAGCGCGAGATCATCCTTCGCGGTACTACCTTACGGCCT
TGGTTCAAGAACATCGTTCATAGCGAGTGA

Protein sequence :
MTRRFLATVAGTALLAGAFAPGVAFGVDASTQTDPVSPTSSATETVNRSDQTASNPTDKTTPAPAAQTGESAQDPKPVKQ
KDFPAVKTQPAQTVDNGREIDKFIRSLDYDPVGVLAVQGEKIETVPVTKESFKNGTYTVFKHEKKTFNNLRGDISVIEAN
NANTFPGALVRANQNLSKGSPTVVGIDRAPITVSVDLPGLLSGKGEKVIQNPHKSSVQGGINELLKGWTDMHSTYPNHAA
KISYDELMVNSKEQLEAKFGLGFEKVANKLDVNFDAIHKHERQVGIASFKQIFYTVSTDTPNNPHELFAKNVTKQDLIDR
NIDKKNPLAYISNVSYGRQIFVKLETDSTDNDVKAAFSAVFKGSFGNGKTDVDTKYKNILNKTRATVYVLGGSAQKGVEV
ATGSIEDLKRIIKEESTFSTTVPAVPVSYTVNFVKDNQRAVVKNTGEYIETTATTYNSGFITLRHRGGYVAKFALEWDEI
SYDEKGVQHVKPVKWAGTWKARTHGFRERIQIPANARNIHVKAGEGTGLAWDKWWTVIDERNIPLVKEREIILRGTTLRP
WFKNIVHSE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hly AAA69525.1 listeriolysin O Virulence LIPI-1 Protein 4e-96 44
slo YP_281505.1 streptolysin O Virulence Not named Protein 1e-82 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Arch_1062 YP_003697395.1 thiol-activated cytolysin VFG0074 Protein 4e-96 44
Arch_1062 YP_003697395.1 thiol-activated cytolysin VFG2275 Protein 5e-83 41
Arch_1062 YP_003697395.1 thiol-activated cytolysin VFG0976 Protein 7e-83 41