Gene Information

Name : thyA (PFREUD_07610)
Accession : YP_003687732.1
Strain : Propionibacterium freudenreichii CIRM-BIA1
Genome accession: NC_014215
Putative virulence/resistance : Unknown
Product : Thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 868177 - 868989 bp
Length : 813 bp
Strand : +
Note : Provides the sole de novo source of dTMP for DNA biosynthesis - dUMP + 5,10-methylenetetrahydrofolate <=> dihydrofolate + dTMP

DNA sequence :
ATGCGTCAATACCTTGACCTGCTCACCCGCGTGATGGACGAGGGCATCGACAAGTCCGACCGCACCGGCGTCGGCACCCG
CAGCGTCTTCGGCCACCAGATGCGCTTCCACCTGGCCGACGGCTTCCCGCTGGTCACCACCAAGAAGATCTACACCCGTG
GCGTGTTCGGCGAGCTGCTGTGGTTCCTGCGCGGCGACACGAACATCGGCTGGCTGCACCGCAACAATGTGCACATCTGG
GACGAATGGGCCGACGAGAACGGCGACCTGGGGCCCGTCTACGGCCACCAGTGGCGCAGCTGGCCGGTGCCCGGTGGCGG
CCACGTCGACCAGCTCGCCAAGGTGATCGACCAGATCAAGAACGACCCCAATTCACGCCGCCTGGTGGTCTCGGCCTGGA
ACGTGGCCGAGGTCGACGACATGGCGCTTCCGCCCTGCCACCTGCTGTTCCAGTTCTACGTGACCCCCGGCGAGGACGGG
CAGCCCGGCAAGCTGTCCTGCGGGCTCTACCAGCGCAGCGCCGACCTGTTCCTGGGCGTGCCGTTCAACATCGCGAGCTA
CGCCCTGCTCACCCACATGGTGGCGCAGGTGTGCGGCCTGGGCGTCGGCGACTTCGTCCACACCCTGGGTGATGCGCACA
TCTACCACAACCACTTCGACCAGGTGGCCGAACAGCTGTCCCGCACGCCCAAGGCGCTGCCGCGGTTGGCGCTCAACCCG
CAGGTGAGGAACATCGACGAGTTCGAGCTGTCCGACATCACCGTGGAGGGCTACGAACCCGACCCCGCCATCAAGGCCCC
CATCGCCGTGTGA

Protein sequence :
MRQYLDLLTRVMDEGIDKSDRTGVGTRSVFGHQMRFHLADGFPLVTTKKIYTRGVFGELLWFLRGDTNIGWLHRNNVHIW
DEWADENGDLGPVYGHQWRSWPVPGGGHVDQLAKVIDQIKNDPNSRRLVVSAWNVAEVDDMALPPCHLLFQFYVTPGEDG
QPGKLSCGLYQRSADLFLGVPFNIASYALLTHMVAQVCGLGVGDFVHTLGDAHIYHNHFDQVAEQLSRTPKALPRLALNP
QVRNIDEFELSDITVEGYEPDPAIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-79 59
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 6e-51 44