Gene Information

Name : thiC (PFREUD_20900)
Accession : YP_003688998.1
Strain : Propionibacterium freudenreichii CIRM-BIA1
Genome accession: NC_014215
Putative virulence/resistance : Unknown
Product : thiamine-phosphate diphosphorylase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : 2.5.1.3
Position : 2254550 - 2256454 bp
Length : 1905 bp
Strand : -
Note : 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphoethyl)-thiazole <=> Pyrophosphate + Thiamin monophosphate

DNA sequence :
ATGGATTCATCCACACCAACAAACACGTCCACCAATGCGCCCGAAAACCGGGTCCGCGCCACGCGGCCGGTGCAATTTGG
GGATTTCACACTGGAAGTGCCCTATCAGGAGATAAAGCTCCAGGATACACCCGGTGGCGGCACCAATGCACCATTCACCG
ATTACTGCACCCAGGGTCCGGACGGTGATTCCGCCCAGGGATTGCCACCGATGCGCCAACCGTGGATCGAGGCCCGCGGC
GACACCGACGCCTATTCCGCGCGTCCGCGCGACCTGGCCGACGACGGCCGCAGGGCGTCCAAGCGCGGCGCGGCCTCCCG
CGAATGGCAGGGCCGCACGCAGACGCCGCTGCGCGCCCGCGACGGACACGCGATCACCCAGATGGCCTACGCCCGGGCCG
GCATCATCACCCCCGAGATGGCCTTCGCCGCCGCCCGCGAGGCGTGCGAGCCCGAACTGGTGCGCAGCGAGCTGGCCGCC
GGGCGTGCCGTGATGCCGCTCAACGTCAACCATCCCGAGGCCGAACCGATGGTGATCGGCTCGCGGTTCCTGGTGAAGAT
CAACGCCAATATGGGCAATTCGGCCACCACGTCGTCGATCGACGAGGAAGTCGCCAAGCTCACCTGGGCCACCACCTGGG
GCGCCGACACCGTGATGGACCTGTCCACCGGCGCCGACATCCACACCACCCGCGAATGGATCCTGCGCAATTCGCCGGTG
CCGATCGGCACCGTGCCGATCTACCAGGCGCTGGAGAAGGTCAACGAGGACGCGTCGAAGCTCAGCTGGGAGATCTACCG
CGACACGGTGATCGAGCAGTGCGAGCAGGGCGTCGACTACATGACCGTGCACGCCGGGGTGCTGCTGCGCTATGTGCCGC
TCACCGCCAACCGCGTCACCGGCATCGTCTCGCGCGGCGGGTCGATCCTGGCCGAATGGTGCCTGGCCCACCACGAGGAG
AACTTCCTCTACACCCACTTCGACGAGCTGTGCGACATCCTGCGCGCCTACGACGTCTGCTTCTCGCTGGGCGACGGCCT
GCGTCCCGGCTCGCTGGCCGACGCCAACGACGAGGCACAGTTCGCCGAACTGCTGACGCTGGCCGAGCTCACCCGACGTG
CCTGGGCCAAGGACGTGCAGGTGATGATCGAGGGGCCCGGCCACGTGCCCTTCGACACGGTGAAGATGAACGTCGAGCTG
GAACAGCAGCTGTGCCAGGGGGCGCCGTTCTACACGCTCGGACCGCTGGTCACCGATGCGGCCCCCGGCTACGACCACAT
CACCTCGGCCATCGGCGCCACCGAGATCGCCCGGTGGGGCACCGCCATGCTGTGTTATGTCACCCCCAAGGAGCACTTGG
GACTACCCGACCGCGACGACGTCAAGACCGGCGTGATCACCTACAAGATCGCCGCGCACGCCGCCGACGTGGCCAAGCAC
CATCCCGGTGCGCGGGATCGCGACGACGCCATCAGTAAGGCGCGCTTCGAGTTCCGCTGGAACGACCAGTTCGACCTGGC
CTTCGACCCCGACACGGCCCGCGGCCTGCACGACGAGACGTTGCCGGCCGAGGGCGCGAAGCTGGCCCACTTCTGCTCGA
TGTGCGGGCCGAAGTTCTGCTCGATGGCCATCTCGCAGAACATCCGCAGCCGGTTCGGTGGGGCGCTGGAGCAGGCCGCC
ATCGTGAACGGCTCGACGACGCTGGGGATGCCGGCCCCGATGTCAGCCCCGGTGGCAGCCGCGGCACCCACGACGGCGCA
GGGGACTGGGGTCGATGGCGGCGAGGTGATTGCCACGCCGCAGGGCCTGGCCGCCGCGATGGCTGCCAAGAGCAGTGAGT
TCCTGGCTGCCGGCGGACATGTCTATGTTGCTGCCGACCAGGCGGGGCGCGCCGACCGGGAGTGA

Protein sequence :
MDSSTPTNTSTNAPENRVRATRPVQFGDFTLEVPYQEIKLQDTPGGGTNAPFTDYCTQGPDGDSAQGLPPMRQPWIEARG
DTDAYSARPRDLADDGRRASKRGAASREWQGRTQTPLRARDGHAITQMAYARAGIITPEMAFAAAREACEPELVRSELAA
GRAVMPLNVNHPEAEPMVIGSRFLVKINANMGNSATTSSIDEEVAKLTWATTWGADTVMDLSTGADIHTTREWILRNSPV
PIGTVPIYQALEKVNEDASKLSWEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTANRVTGIVSRGGSILAEWCLAHHEE
NFLYTHFDELCDILRAYDVCFSLGDGLRPGSLADANDEAQFAELLTLAELTRRAWAKDVQVMIEGPGHVPFDTVKMNVEL
EQQLCQGAPFYTLGPLVTDAAPGYDHITSAIGATEIARWGTAMLCYVTPKEHLGLPDRDDVKTGVITYKIAAHAADVAKH
HPGARDRDDAISKARFEFRWNDQFDLAFDPDTARGLHDETLPAEGAKLAHFCSMCGPKFCSMAISQNIRSRFGGALEQAA
IVNGSTTLGMPAPMSAPVAAAAPTTAQGTGVDGGEVIATPQGLAAAMAAKSSEFLAAGGHVYVAADQAGRADRE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 3e-169 63
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 3e-169 63
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 2e-157 61