Gene Information

Name : aldB (PFREUD_19300)
Accession : YP_003688842.1
Strain : Propionibacterium freudenreichii CIRM-BIA1
Genome accession: NC_014215
Putative virulence/resistance : Virulence
Product : lactaldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.22
Position : 2080763 - 2082259 bp
Length : 1497 bp
Strand : -
Note : (S)-lactaldehyde + NAD(+) + H(2)O <=> (S)-lactate + NADH

DNA sequence :
ATGGCAAGCAACTACCAGCTACCCGACACCTATGGCATGTACATCGGTGGCGAGTGGCGCCAGGCGTCGGACGGCGCCAC
CATCAATGCCTTCAACCCGGCCAACGGCAGCGCGCTGGCCACCATCCCCGACGCCACGCAGCGTGACGTGGATGACGCGG
TACGCGCCGCCCGTGCGGCGTTCCTGGGCTGGGCCGAGACCCCGGTGCAGGCGCGCTCCCGGGCGATGCTCGACATCGCC
GACCTCATCCAGGACAACCTGGACTTCCTGGCCACCGTGGAATCGATGGACAACGGCAAGCCCATCCGCGAGACGAGCAA
CGCCGACATCCCGCTGTCGGTTGACCACTTCCGCTATTTCGCCGGCGTGATGCGTGCCGACGAGGGCGCGGCCACCATGA
TCGACCAGAACACGCTGAACATCATCCTGCGCGAACCGCTGGGCGTCATCGGCCAGATCGTGCCGTGGAACTTCCCGTTC
CTGATGGCCGCCTGGAAGCTCGCCCCCGCACTGGTGTCGGGCAACACGGTGGTGTTCAAGCCCTCCAGCGCCACCTCGCT
GTCGGTGCTGGAACTGGCCCGCCTGGTTGACGAGGCCGGCATCCTGCCGACCGGCGTGTTCAATGTGATCACCGGTTCGG
GTGGCAAGTCCGGCGAATACCTGCAGCACGCCGATGTCGACAAGCTCGCCTTCACCGGATCCACCGAGGTGGGACGCCGG
ATCGCGCTCGCCGCCGCCGAGAAGATCATCCCGGCCACCCTCGAACTCGGCGGCAAGTCCGCCTCGGTGTTCTTCGACGA
CGCCGACCCCGATGTGGCGCTGAACGGCGTCGAGATGGGCATCCTGTTCAACCAGGGCCAGGTCTGCTCGGCGGGTTCGC
GCATCTTCGTGCAGCAATCGGTGATGGACGACTTCATGGCCAGGCTCACGAACTCGTTCGAGAACGTGAAGATCGGCGAT
CCGCTCGACCCGAGCACCCAGATGGGTGCCCAGATCGACGAGCGCCAGCTCGACAAGATCCTGGAATACGTCGACCTCGG
CAAGCAGGAGGGAGCCAGCCTGGCGGTCGGTGGCCAGCGCGTCACCACCGGAGACCTGGGCAAGGGCGTGTTCATGGAGC
CGACGCTGCTGGTGGGCGACAACGACATGCGCGTGGCTCGCGAGGAGATCTTCGGACCCGTCGGCGTGGTGATCCCCTTC
AAGGACGAGGACGACGTGGTGCGCATGGCCAATGACTCGATCTACGGCCTGGGCGGTGGCGTGTTCTCGAAGAGCCTCGA
GCGGGCCATCCGCGTGGCCACCCGGGTGCGCACCGGGCGCATCTGGGTGAACCAGTACAACGCGTTCCCGGCCGGCGCCC
CCTTCGGTGGCTACAAGAATTCCGGTATCGGGCGCGAGACGCACAAGATGATCCTGGATGCCTACCAGCAGACGAAGAAC
ATCCTGGTGAACCTGTCGGGCCAGCCGGTCGGCCTGCCCTACAACCTGGGCGACTGA

Protein sequence :
MASNYQLPDTYGMYIGGEWRQASDGATINAFNPANGSALATIPDATQRDVDDAVRAARAAFLGWAETPVQARSRAMLDIA
DLIQDNLDFLATVESMDNGKPIRETSNADIPLSVDHFRYFAGVMRADEGAATMIDQNTLNIILREPLGVIGQIVPWNFPF
LMAAWKLAPALVSGNTVVFKPSSATSLSVLELARLVDEAGILPTGVFNVITGSGGKSGEYLQHADVDKLAFTGSTEVGRR
IALAAAEKIIPATLELGGKSASVFFDDADPDVALNGVEMGILFNQGQVCSAGSRIFVQQSVMDDFMARLTNSFENVKIGD
PLDPSTQMGAQIDERQLDKILEYVDLGKQEGASLAVGGQRVTTGDLGKGVFMEPTLLVGDNDMRVAREEIFGPVGVVIPF
KDEDDVVRMANDSIYGLGGGVFSKSLERAIRVATRVRTGRIWVNQYNAFPAGAPFGGYKNSGIGRETHKMILDAYQQTKN
ILVNLSGQPVGLPYNLGD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 4e-106 50
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 2e-111 48
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 2e-111 48
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 2e-111 48
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 7e-111 48

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
aldB YP_003688842.1 lactaldehyde dehydrogenase VFG0082 Protein 2e-106 50