Gene Information

Name : Mesil_0004 (Mesil_0004)
Accession : YP_003683460.1
Strain : Meiothermus silvanus DSM 9946
Genome accession: NC_014212
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : -
Position : 4192 - 5616 bp
Length : 1425 bp
Strand : +
Note : COGs: COG0469 Pyruvate kinase; InterProIPR015813:IPR015795:IPR011037:IPR015793:IPR 015794:IPR001697:IPR018209; KEGG: ttj:TTHA0003 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: C1XVA7 Pyruvate kina

DNA sequence : 
ATGGCGTTTACTAAACGAACTAAGATTGTAGCCACGTTGGGACCCGCCTCCTCGAGCCCTGAGGTTATTCGTAAGCTCAT
CCAAGCGGGGGCCGATGTCTTCCGCCTCAACTTCAGCCATGGTTCCCCGGAGGATCACCGCGAACGGGTAGCCCACATCC
GCCAGGCCGCGGAGGAGTTAGGCCAGACGGTAGCTATCCTGCAGGATTTGCAAGGCCCTAAGATCCGGGTGGGCCGCTTC
GCTGAAGGAGCGGTGGAGCTTGTTCCCGGAGCTAAGTTCATCCTCACACGGGAATCCGTAGAAGGAGATGCCCACCGGGT
TTCGGTGACCTACCGAGGTCTTCCCGAGGACGTGCTACCGGGTCAGGAGTTGTTGCTTGATGACGGAAATATCCGCCTCA
GGGTAGACGAGGTGCGCGGCCCCGATATCTATACCACGGTGGTGATTGGCGGACGGCTTTCCAACAACAAGGGCATCAAC
ATCCCCGGAGCCGATCTTTCGATCCCTGCGCTCACCGACAAGGACATCGAGGACTTGGTGTTAGGGGTCGAGCTCGAGGT
GGACTGGGTGGCCATGAGCTTTGTCCGTAGCCGAGACGACTTACTTTTGGCCCGCCACTATCTGACGCGTCACGCCTCCC
GCGCAAGGTTGATGGCTAAGATAGAAAAGCCCTCGGCGGTGATGCGCTTCGATGAAATCCTGGAGGAAGCCGATGGGATC
ATGGTGGCCCGCGGCGACCTGGGTGTGGAGATGCCTTTGGAAGAGGTCCCGGTGGTGCAAAAACGCCTAATCCTCAAGGC
CATCCAAACCGGAAAGCCGGTCATTACCGCCACCCAGATGCTCGAAAGCATGATCAAGAACCCCATCGCTACCCGGGCTG
AGGCGTCCGACGTAGCCAATGCGGTCTTCGACGGTACCGATGCGGTTATGCTCTCTGCCGAGACCGCCTCAGGTTCCTAC
CCAGTTGAGGCAGTCTCCTTTATGGCCCGGGTGGCCCGCAACGTAGAGGCCTCCACCGAGTACCGGGTACGGCTCAACGC
CCTGCGCCCGTCCCCTACCCCCTCGGTACAAGATGCTATCGCCATGGCTGTGGACGATGTAGTCGAGGCGGTGGGGGCTC
GGGTGATCGTAGCTTTTACCGCGACCGGCGGGGCCGCCCGGCGCATTGCCCGCACCAAGCCACCGGTGCCGATCCTGGCC
CTCACCCCCAACCCCCACGTGCGCAACCAACTGGCCTTGGTCTCGGACGTCTACCCTTTGTTGGCCCCTGACCCCAAGGA
CACCGATGACATGGTGCAGATCGCCGTGGCTAAGGCCAAGGAAACGGGCCTTGCCCAGGTGGGGGAGTACGTGGTGATCG
CGGCAGGCGTACCGTTTGGGGTGCGCGGGACGACCAACATGCTCCGAGTGGAGCGGGTGAGCTAA

Protein sequence : 
MAFTKRTKIVATLGPASSSPEVIRKLIQAGADVFRLNFSHGSPEDHRERVAHIRQAAEELGQTVAILQDLQGPKIRVGRF
AEGAVELVPGAKFILTRESVEGDAHRVSVTYRGLPEDVLPGQELLLDDGNIRLRVDEVRGPDIYTTVVIGGRLSNNKGIN
IPGADLSIPALTDKDIEDLVLGVELEVDWVAMSFVRSRDDLLLARHYLTRHASRARLMAKIEKPSAVMRFDEILEEADGI
MVARGDLGVEMPLEEVPVVQKRLILKAIQTGKPVITATQMLESMIKNPIATRAEASDVANAVFDGTDAVMLSAETASGSY
PVEAVSFMARVARNVEASTEYRVRLNALRPSPTPSVQDAIAMAVDDVVEAVGARVIVAFTATGGAARRIARTKPPVPILA
LTPNPHVRNQLALVSDVYPLLAPDPKDTDDMVQIAVAKAKETGLAQVGEYVVIAAGVPFGVRGTTNMLRVERVS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 4e-76 44
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 2e-76 44
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 2e-76 44
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 3e-76 44
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 1e-64 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mesil_0004 YP_003683460.1 pyruvate kinase VFG0479 Protein 1e-76 44