Gene Information

Name : Mesil_1148 (Mesil_1148)
Accession : YP_003684558.1
Strain : Meiothermus silvanus DSM 9946
Genome accession: NC_014212
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 1136347 - 1137720 bp
Length : 1374 bp
Strand : -
Note : COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR012999:IPR013027:IPR004099:IPR011796:IPR 000815:IPR001327:IPR016156; KEGG: ttj:TTHA1153 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide

DNA sequence : 
ATGAGCTACGACCTCCTCATCATAGGCTCGGGCTCGGCGGGGGTGGCCGCGGCCTTGGAAGCGGCCTCCAAAGGGGCTAA
AGCCGCGGTCATCGAGGGTGGAGTCCTGGGCGGGACCTGCGTCAACGTGGGCTGCGTGCCCTCCAAGGCCTTGCTGCGTG
CTGCCGAAGCCTTCCACAAGGCCGGACATCACCCCTTCCGGGGGATTCGGACCCAAGCCGAGAGGGTCGAGCTGGAGCAG
GTTATCGAGCAAAAAGATGCCCTGGTGCGTAGCCTGCGCCAGGAGAAGTACGCCGAGGTGCTGGAGGCCGCCGGGGCCCC
CCTGATCCGCGGTCAGGCCCGTTTCCTCGACGGGGAGACCCTGGAGGTAAACGGGCAGGTCCACAAGGCCCAGCGCTACC
TGCTCGCCACTGGCGCATCTGCGACGCTGCCCCCCATCCCTGGCCTGGCTGATAGCAAGCCCTGGACCTACCCTGAAGCC
CTCTCCCCGGACAGACAGCCCCAAAACCTCCTGGTCATCGGCGTAGGGGCTATCGGTCTGGAGATCGCCCAGGCCTATGC
CCGGCTGGGAACGGAGGTAACCGTGCTCGAGGCCACCCCCTACCTGCTCCCCAGCGAAGACCCTGAGCTTTCCACGATGC
TCAGGGGCTACCTCGAGGCCGAAGGGCTTTCGGTCCACACCGGGGTCCGGGTAGAGCGGGTGGAGCGCGACAGTGAATTC
CGGGTACACACCGAGGGCGGGGTGTTCCGCGCCGAACGCTTGCTGGTAGCCACCGGGCGCAAACCCCGCACCGGGGGGCT
CGAGTTGGAGGCCGCCGGGGTGGGACTAGGCCCGCGGGGAGAGATTCAGGTGGATGCACACCTCAAGACCAGCAATCCTC
GCGTCTTTGCCGCGGGTGACGCCGCGGGTTTGCCGCAGTACGTCTATGTGGCCGCCCAGTCCGGGCGCGTCGCGGCGCGG
AATGCGCTGGGAGGGGAAGAAGCCCTCGATCTTCAAGCGGTGCCCCGCGTGACCTTCACCGACCCTGCCCTGGCCACGGT
GGGGCTTACCGAGGAAGAGGCCCGTAAGCGGTATGGTTCAGGCATCCGGGTGGCCAGGCTCCCCTTAGACCAACTCCCCA
AAGCCTTAGCGCAGCATGACCCGCGGGGGATGTTCAAACTGGTGGTCGATACCGAGGGAGGGGTGCTAGGGCTTTCCATC
CTGGCTCCTGAGGCTGGCGACGCGCTGCAGGAGGCGGTGCTGGCGGTCAAGTTTGGTCTTAATTACCGCGACCTGATCGA
CACCTTCCACCCCTACCTGACCCTGGCCGAGGGCATCCGGCTGGTGGCCCAGGCCCTCGATACCGAGGTAGGAAGGCTCT
CGTGCTGCGCTTAG

Protein sequence : 
MSYDLLIIGSGSAGVAAALEAASKGAKAAVIEGGVLGGTCVNVGCVPSKALLRAAEAFHKAGHHPFRGIRTQAERVELEQ
VIEQKDALVRSLRQEKYAEVLEAAGAPLIRGQARFLDGETLEVNGQVHKAQRYLLATGASATLPPIPGLADSKPWTYPEA
LSPDRQPQNLLVIGVGAIGLEIAQAYARLGTEVTVLEATPYLLPSEDPELSTMLRGYLEAEGLSVHTGVRVERVERDSEF
RVHTEGGVFRAERLLVATGRKPRTGGLELEAAGVGLGPRGEIQVDAHLKTSNPRVFAAGDAAGLPQYVYVAAQSGRVAAR
NALGGEEALDLQAVPRVTFTDPALATVGLTEEEARKRYGSGIRVARLPLDQLPKALAQHDPRGMFKLVVDTEGGVLGLSI
LAPEAGDALQEAVLAVKFGLNYRDLIDTFHPYLTLAEGIRLVAQALDTEVGRLSCCA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 6e-83 46
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 4e-83 46
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 3e-71 45
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 6e-72 45
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 2e-71 45
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 3e-69 44
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 3e-69 44
merA AFG30120.1 MerA Not tested PAGI-2 Protein 3e-69 44
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 1e-70 44
merA ABQ57371.1 MerA Not tested SGI1 Protein 3e-71 44
merA AGK07021.1 MerA Not tested SGI1 Protein 3e-71 44
merA AGK07079.1 MerA Not tested SGI1 Protein 3e-71 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mesil_1148 YP_003684558.1 mercuric reductase BAC0651 Protein 3e-83 46
Mesil_1148 YP_003684558.1 mercuric reductase BAC0650 Protein 8e-73 45
Mesil_1148 YP_003684558.1 mercuric reductase BAC0652 Protein 3e-72 44
Mesil_1148 YP_003684558.1 mercuric reductase BAC0653 Protein 5e-70 43