Gene Information

Name : Tmath_2122 (Tmath_2122)
Accession : YP_003677805.1
Strain : Thermoanaerobacter mathranii A3
Genome accession: NC_014209
Putative virulence/resistance : Resistance
Product : D-alanine/D-alanine ligase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : -
Position : 2143676 - 2144755 bp
Length : 1080 bp
Strand : -
Note : KEGG: tpd:Teth39_0187 D-alanyl-alanine synthetase A; TIGRFAM: D-alanine/D-alanine ligase; PFAM: D-alanine--D-alanine ligase domain protein

DNA sequence :
ATGGTAAAGAAGAGAATTGCTGTTTTATTTGGAGGACAATCAGGAGAACATGAGGTCTCTTTAATGTCTGCAAAGTCTAT
AATAAACAATCTCGATAAAGATAAATACGAGATTTACATGGTAGGTATTACAAAAAAAGGAGAATGGTATCTATATAGGG
GTGACGTAGAGAAAATAGAAACCGGAGAATGGGAAAAAGAAGGAATTCCCGCAACTATGGGAGCTTCTACAAAGTATAGA
GGAATAATAACTTTTGAAGAAGGAAAAAATGTTTTTTTTCCTATAGACGTGGTATTTCCTGTATTGCATGGCCCTAATGG
AGAAGATGGGACTATACAAGGGCTTTTAGAATTATTGGATATACCTTACGTAGGTGCTAATGTGCTTTCTTCTGCTTTAT
GCATGGATAAAGTTTTTACAAAAAGAATTTTTAAGGAAGCTGGATTGCCTACACCTGATTTTGTAGTAGTTTATAGAAAA
GAAATTGGAGATTTAGAAACTATTAAAAAGAAAATTGAGCACTTAGGATATCCTTGTTTTGTAAAACCAGCTAATTTGGG
ATCAAGTGTTGGTATTACCAAAGTCCACAACGAGGAAGAACTTCCTGGGGCCTTGAAATTAGCTGCAAAATATGATAGAA
AATTGTTGATAGAAAAAGGAATAGAGGCCAGAGAGATTGAATGCTCTGTTTTGGGGAATGAAAATCCTGAGGCTTCTGTT
GCGGGAGAAATTGTACCTTCAAATGAGTTTTATGATTACAATGCCAAATATTTTGATGGAGGAAAGTCACTTCTTTTAAT
ACCTGCTCCACTACCTGATGAAAAAATGGAAGAGATAAGAAAGCTCGCTATAAAAGCCTACAGAGCCTTGGATTTAAGAG
GCATGGCGAGAGTAGACTTTTTAATGGATAGAAATACAGGCACTGTTTACCTAAATGAAGTTAACACTATTCCGGGCTTT
ACGAAAATAAGTATGTACCCTAAACTATGGGAAGCGAGTGGAAAGTCCTATTCGGCATTATTGGATGACCTTATAAATTT
AGCAATAGAAAGTAATAATGAAAAATGTAGGGAATGGTGA

Protein sequence :
MVKKRIAVLFGGQSGEHEVSLMSAKSIINNLDKDKYEIYMVGITKKGEWYLYRGDVEKIETGEWEKEGIPATMGASTKYR
GIITFEEGKNVFFPIDVVFPVLHGPNGEDGTIQGLLELLDIPYVGANVLSSALCMDKVFTKRIFKEAGLPTPDFVVVYRK
EIGDLETIKKKIEHLGYPCFVKPANLGSSVGITKVHNEEELPGALKLAAKYDRKLLIEKGIEAREIECSVLGNENPEASV
AGEIVPSNEFYDYNAKYFDGGKSLLLIPAPLPDEKMEEIRKLAIKAYRALDLRGMARVDFLMDRNTGTVYLNEVNTIPGF
TKISMYPKLWEASGKSYSALLDDLINLAIESNNEKCREW

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 7e-56 41
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 7e-55 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase AF130997.1.orf4.gene Protein 4e-54 43
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase AY489045.gene.p01 Protein 3e-56 43
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase AF277571.gene.p01 Protein 4e-56 42
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase AF162694.gene.p01 Protein 4e-56 42
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase U35369.1.gene6.p01 Protein 3e-56 41
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase AE016830.1.gene2250. Protein 3e-56 41
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase U00456.gene.p01 Protein 3e-56 41
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase AY145441.gene.p01 Protein 7e-56 41
Tmath_2122 YP_003677805.1 D-alanine/D-alanine ligase AF310956.2.orf5.gene Protein 2e-55 41