Gene Information

Name : Srot_1778 (Srot_1778)
Accession : YP_003659069.1
Strain : Segniliparus rotundus DSM 44985
Genome accession: NC_014168
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 1784485 - 1786206 bp
Length : 1722 bp
Strand : -
Note : TIGRFAM: urease, subunit alpha; KEGG: nfa:nfa25260 urease subunit alpha; PFAM: amidohydrolase; Urease alpha-subunit domain protein

DNA sequence :
GTGAGCCGTATCGAGCGCCTTCGTTACGTTGGGCTCTACGGTCCGACCGTCGGGGACCGCATCCGGCTCGCGGACACGGA
CCTGTTCGTCGAAGTCACCGAGGACCTGTGCGGCGGCCCCGGCAAAGCGGGCGACGAGGCGGTGTTCGGCGGCGGGAAAG
TCTTGCGCGAGTCGATGGGGCAAGGGCGCGCCACCCGAGCCGAAGGCGCCCCGGACACGGTCATCACCGGCGCGGTGGTG
TTGGACTGGTGGGGAGTGGTCAAAGCCGACGTCGGCATCCGGGACGGGCGTATTGCCGCCCTGGGCAAAGCCGGCAATCC
GGACACGATGCACGGTGTGCACCCGGACCTCGTCGTCGGCCCGAGCACCGAGGTGATCTCTGGGAACGGCAAGATCCTCA
CGGCGGGCGGGATCGACTGCCATGTGCATTTCATCTGCCCCCAGATCATCCCCGAAGCCCTCGGCTCAGGACTGACGACC
CTCATCGGCGGCGGCACGGGCCCCGCGGAGGGCTCGAAGGCGACCACGGTGACCCCCGGCGAATGGCATCTCGCGCGGAT
GCTGGAGGCGTTGGACGGGGAGCCGATGAACTTCGTCCTCCTCGGCAAAGGTTCGACCGTTTCTGAAGAGGGCATGTGGG
AGCAGCTGCGCGCCGGGGCCTGCGGATTCAAAATCCACGAGGACTGGGGCGCGACCCCGGCCGCGATTGACGCGTGCCTG
CGCGTCGCGGACCAGTCGGGCGTGCAGGTGGCTTTGCACACCGACACCCTCAACGAGCTCGGCTACATCGCGGACACCCT
CGCCGCGATCCGAGGCCGGTGCATCCACACCTATCACACCGAGGGCGCGGGAGGCGGGCACGCGCCGGACATCATCACTG
TCGCCTCGCAACCGAATGTGCTGCCGAGTTCGACGAACCCCACCCGGCCCCACACGGTCAACACGATTGACGAGCACCTG
GACATGCTCATGGTCTGCCACCACCTCAACCCGGCGATCCCCGAGGACCTCGCGTTCGCCGAAAGCCGCATCCGGCCGTC
CACCATCGCCGCCGAGGACCTGCTGCACGATCTTGGCGCGATCTCCATGATCGGAAGCGACGCGCAGGCCATGGGCAGAG
TCGGGGAAGTCATCATCCGAACCTGGCAGAGCGCGCACATGATGAAATTGCGGCGCGGCGCGCTCCCCGGCGACGGGATG
GCCGACAACAACCGCGCCCGCCGGTACATCGCCAAGTACACGATCTGCCCGGCCATCGCGCACGGACTCGACCATGAGAT
CGGCAGCGTCGAAGTGGGCAAGCTCGCCGACCTGGTGCTCTGGGACACGGCGTTCTTCGGCGTGCGCCCGCATCTGGTGC
TCAAAGGGGGAGCGATCGCTTTGGCGCAGATGGGAGACGCGAACGCCTCTATCCCGACCCCGCAGCCCGTGTTGCCCAGG
CCGATGTTCGGAGCCTCCGCCGCCGCTGCGGCCGCGACTTCGGCGCACTTCGTCGCGGAGGCCGCCGTTCAGGCGGGACT
CGCCGACCGGCTCGCGGTGCGGCGGCGGTTGGTCGCGGCGAAGGACGTGCGCGCGGTGCGCAAGGAAGACCTCAAGCTCA
ACGAGGCGATGCCAGACATCCAGGTGGACCCGGACACCTTCACGGTGCGGGTGGACGGCGAGGTCTTCGAGGAACAGCCC
GCAGCCGTGCTGCCCATGGCGCAGCGGTATTTCTTGTTCTGA

Protein sequence :
MSRIERLRYVGLYGPTVGDRIRLADTDLFVEVTEDLCGGPGKAGDEAVFGGGKVLRESMGQGRATRAEGAPDTVITGAVV
LDWWGVVKADVGIRDGRIAALGKAGNPDTMHGVHPDLVVGPSTEVISGNGKILTAGGIDCHVHFICPQIIPEALGSGLTT
LIGGGTGPAEGSKATTVTPGEWHLARMLEALDGEPMNFVLLGKGSTVSEEGMWEQLRAGACGFKIHEDWGATPAAIDACL
RVADQSGVQVALHTDTLNELGYIADTLAAIRGRCIHTYHTEGAGGGHAPDIITVASQPNVLPSSTNPTRPHTVNTIDEHL
DMLMVCHHLNPAIPEDLAFAESRIRPSTIAAEDLLHDLGAISMIGSDAQAMGRVGEVIIRTWQSAHMMKLRRGALPGDGM
ADNNRARRYIAKYTICPAIAHGLDHEIGSVEVGKLADLVLWDTAFFGVRPHLVLKGGAIALAQMGDANASIPTPQPVLPR
PMFGASAAAAAATSAHFVAEAAVQAGLADRLAVRRRLVAAKDVRAVRKEDLKLNEAMPDIQVDPDTFTVRVDGEVFEEQP
AAVLPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 5e-147 60
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 5e-147 60
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-138 58
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-138 58
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-138 58
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-138 58

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Srot_1778 YP_003659069.1 urease subunit alpha VFG0270 Protein 1e-128 55