Gene Information

Name : Tbis_3117 (Tbis_3117)
Accession : YP_003653704.1
Strain : Thermobispora bispora DSM 43833
Genome accession: NC_014165
Putative virulence/resistance : Resistance
Product : cystathionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.1
Position : 3658133 - 3659272 bp
Length : 1140 bp
Strand : -
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class V; KEGG: rce:RC1_1986 cystathionine gamma-synthase (CGS) (O-succinylhomoserine(thiol)-lyase)

DNA sequence :
ATGAACCACGGTTTCGAGACCCTCGCGATCCACGCCGGTCAGGAGCCGGACCCGCACACGGGCGCGGTCGTCCCGCCCAT
CTACGCGGTCTCCACCTACAAGCAGGACGGCGTGGGCGGGCTGCGGTCCGGGTACGAGTACAGCCGCTCGGCCAACCCCA
CCAGGACGGCCCTGGAGGAGGCCCTCGCCGCGGTGGAGGGCGGCGTGCGCGGCCTGGCGTTCGCGTCCGGCCTGGCCGCC
GAGGACACGCTGATCCGCACCGTCTGCCGCCCCGGGGACCACGTGCTCATCCCGGACGACGCGTACGGCGGCACCTACCG
GCTGTTCGCGAAGGTGCTCGAGCGGTGGGGCCTCGCCTACGAGCCGGTGCCGATGGGCGACCTCGACGCGGTGCGCGCGG
CCGTGCGGGACACCACCAAGGTGATCTGGGTGGAGACGCCCACCAACCCGCTGCTCACGGTCGCGGACATCGCCGCGCTC
GCGGGCATCGCGCACGAGGCCGGCGCGCTGCTCGTGGTGGACAACACGTTCGCCTCGCCGTACCTGCAGCAGCCGCTCGC
GCTCGGCGCGGACGTGGTGGTGCACTCGACCACCAAGTACATCGGCGGCCACTCCGACGTGGTCGGCGGCGCGCTGATCG
TCCGCTCGACCGAGCTGGGGGAGCGGCTCGCCTACCACCAGAACGCGATGGGCGCGGTCGCCGGACCGTTCGACGCGTGG
CTCGTGCTGCGCGGGCTCAAGACGCTCGCGGTCCGGATGGAGCGGCACTGCGACAACGCCGAGCGCGTCGTGGAGATGCT
GCGCGCGCACCCGCGGGTGACCCAGGTGCTCTACCCCGGGCTGCCCGGCCACCCCGGCCACGAGGTGGCGGCGAAGCAGA
TGCGGCGGTTCGGCGGGATGGTGTCGTTCCGGGTCGCCGGCGGCGAGGAGGAGGCGGTCGAGATCTGCGGCCGGACCCGC
CTGTTCACCCTCGGCGAGTCGCTCGGCGGGGTGGAGTCCCTGATCGAGCACCCGGGCCGGATGACCCACGCCTCGGCCGC
CGGGTCGCCCCTCGAGGTCCCGTCCGACCTCATCCGGCTGTCGGTCGGCATCGAGACCATCGACGACCTGCTCGCCGACC
TCGCCCAGGCGCTCGGCTGA

Protein sequence :
MNHGFETLAIHAGQEPDPHTGAVVPPIYAVSTYKQDGVGGLRSGYEYSRSANPTRTALEEALAAVEGGVRGLAFASGLAA
EDTLIRTVCRPGDHVLIPDDAYGGTYRLFAKVLERWGLAYEPVPMGDLDAVRAAVRDTTKVIWVETPTNPLLTVADIAAL
AGIAHEAGALLVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALIVRSTELGERLAYHQNAMGAVAGPFDAW
LVLRGLKTLAVRMERHCDNAERVVEMLRAHPRVTQVLYPGLPGHPGHEVAAKQMRRFGGMVSFRVAGGEEEAVEICGRTR
LFTLGESLGGVESLIEHPGRMTHASAAGSPLEVPSDLIRLSVGIETIDDLLADLAQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-64 47
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-63 46
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-48 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tbis_3117 YP_003653704.1 cystathionine gamma-lyase BAC0207 Protein 2e-52 43