Gene Information

Name : Tbis_2610 (Tbis_2610)
Accession : YP_003653205.1
Strain : Thermobispora bispora DSM 43833
Genome accession: NC_014165
Putative virulence/resistance : Virulence
Product : urease
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 3064621 - 3066309 bp
Length : 1689 bp
Strand : -
Note : PFAM: Urease alpha-subunit domain protein; amidohydrolase; KEGG: aeh:Mlg_0184 urease subunit alpha

DNA sequence :
GTGACCACGATCCCCCGGCGCACCTACGCCGCGCTCTACGGCCCGACCACCGGTGACCGGATCCGGCTCGGCGACACCTG
CCTCTGGGTGGAGGTCGAAGCCGACGACACCTCCTACGGCGATGAGCTGCTCGGCGGCTGCGGCAAGACGCTGCGCGACG
GGCTGCTCGCCTCACCCAGCGCGTCCGGCGACTCCGCCCTCGACCTCGTCGTGGCCAACGTCGTCCTGCTCGACCCGCTC
CTCGGGGTCCGCAAGACCCACATCGGCGTCAAGGACGGCCGGATCGTGGCGGTCGGCCGCGGCGGCAACCCCGACCTGGT
CCCGGACGTGGAGCTCGTCATCGGCTCCCACACCGCGATCGTCACCGGGGAGGGCCTGATCTGCACCCCCGGCATCATCG
ACTCCCACGTCCACCTCTCCTCGCCGGAGATCGCCCCGGCCGCCCTCGCCTCCGGGGTCACCACGGTCGTCGGCATGGGC
CTCGGCGGGGTGTGGGACGTCGGCGTCAACCCCGCCCACAACCTGCACACGCTCATGTCCGCCTGGCGGGGCACCCCGCT
CAACGTGGCCTTCCTCGCCCGTGGCTCGTCCAGCTCCGCCGCGCTGCTCGAGGCGGCCGTGCTCGCCGGCGCCGGCGGCT
TCAAGATCCACGAGGACTTCGGGGCCACCCCGCGGACCATCGACACCTGCCTGACCGTCGCCGAGCAGGCCGACCTGCCG
GTCGCGCTCCACACGGACTCCATGAACGAGTCCGGCTACCTCGCGGACACCATCGCCGCGACCCGCGGCCGCACCGTGCA
CGCGTACCACGTGGAGGGCGGCGGCGGGCACCCCAACCTGCTGGAGATCCTCAGCGAGCCGCACATCATCCCCTCCTCGA
CCACGCCGACCATCCCCTACACCACGAACACGGTCGGGGAGCTCTTCCCGATGACGATGACCGTCCACCGGCAGAGCCAC
CACATCGAGAGCGACGTGGCGGTCACCCGGAGCCGCATCCGCGAGCACGCCATCGCCGCGGAGAACGCGCTCCACGACAT
CGGCGCGATCAGCATCGTCAACTCCGACTCCATGGGCATGGGCCGGGTGGCCGAGACCGCCCGCCGTACCTGGCAGCTCG
CCCACCTGCAGGCGCTGCGCGCCGGGGAGGGCGGCCCGGACCGGCCCGCCAACGCCCGGGTGCTGCGGTACCTCGCCAAG
CTCACCCTCAACCCGGCGATCGCGCACGGCATCGCCCACGAGGTCGGCAGCGTCCGGCCCGGCCGCCTCGCCGACCTGGT
GCTGTGGCACCCGGCCTGGTTCGGCACCAAGCCCGAGCTCGTGATCAAGGGCGGGTTCGTGGCCTGGGGGGTGTCCGGCA
GCGGATCGGGCTCCACCCGGCTCACCCAGCCCCGGGTCTACCGGCCGTACTTCGGCGGGCTCGGCGACGCGCCCGCCCGG
CTCGGCCGGGTCTTCGTCGCCCGGGAGGCGCTGGAGTCGGCCGAGGCGCGCGAGGCGCTCCCGCCCGGCCTGCGGTACGC
GCCGATCCGCGACGCCCGCGGCCTCACCCGCGCCGACATGTGCCGCAACACCGCGACCCCGCGCGTGGAGGTCCCGCCCG
GCCCCGAGCCCGTCCTGGTGGACGGCGAGCCGGTGCGGGTGGAGCCGGCCACGCGGGTGCCGCTCGCCCAGCTCCACCAC
ATCGCCTGA

Protein sequence :
MTTIPRRTYAALYGPTTGDRIRLGDTCLWVEVEADDTSYGDELLGGCGKTLRDGLLASPSASGDSALDLVVANVVLLDPL
LGVRKTHIGVKDGRIVAVGRGGNPDLVPDVELVIGSHTAIVTGEGLICTPGIIDSHVHLSSPEIAPAALASGVTTVVGMG
LGGVWDVGVNPAHNLHTLMSAWRGTPLNVAFLARGSSSSAALLEAAVLAGAGGFKIHEDFGATPRTIDTCLTVAEQADLP
VALHTDSMNESGYLADTIAATRGRTVHAYHVEGGGGHPNLLEILSEPHIIPSSTTPTIPYTTNTVGELFPMTMTVHRQSH
HIESDVAVTRSRIREHAIAAENALHDIGAISIVNSDSMGMGRVAETARRTWQLAHLQALRAGEGGPDRPANARVLRYLAK
LTLNPAIAHGIAHEVGSVRPGRLADLVLWHPAWFGTKPELVIKGGFVAWGVSGSGSGSTRLTQPRVYRPYFGGLGDAPAR
LGRVFVAREALESAEAREALPPGLRYAPIRDARGLTRADMCRNTATPRVEVPPGPEPVLVDGEPVRVEPATRVPLAQLHH
IA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 4e-70 47
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 4e-70 47
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 6e-69 43
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 5e-69 43
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 5e-69 43
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 5e-69 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tbis_2610 YP_003653205.1 urease VFG0270 Protein 2e-65 44