Gene Information

Name : Tbis_1741 (Tbis_1741)
Accession : YP_003652347.1
Strain : Thermobispora bispora DSM 43833
Genome accession: NC_014165
Putative virulence/resistance : Virulence
Product : betaine-aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.8
Position : 2013737 - 2015251 bp
Length : 1515 bp
Strand : +
Note : PFAM: Aldehyde Dehydrogenase; KEGG: rce:RC1_1452 gamma-glutamyl-gamma- aminobutyraldehyde dehydrogenase

DNA sequence :
ATGACCGTCATACCGGAAGCCGAGGCGCGCGCCAGGCGGGAGGAGCTCGAGAAGCGCTTCGCCGGCCTGTCCTTCCCCAC
CCGGCTGTTCATCGACGGCCGGTACGTGGACGCGGCGAGCGGCGCCACGCTCGACCGGATCTCCCCCCGGAACGGCAAGC
TGATCGCCAAGGTCGCCGCCGGGGACGAGGAGGACATCGACCGGGCTGTCGCCGCCGCCCGGCGCGCCTTCGAGAGCGGC
CGGTGGTCCGGACTGCACCCGCGCGAGCGGCGCAAGGTGCTCCAGCGGCTGGCCCGCCTCGTCGAGGAGCACGCCGAGGA
GCTGGCGCTGCTCGAGAGCGTCGACATGGGCAAGCCGTTCACCGACGCGCTCGCGGTCGACATCCGGGTGACCGTGCAGT
GCCTCGACTTCTACGCCGAGGCGGTGGACAAGCTGTACGACGAGGTGGCCCCCACCGGCCCGGACGTCCTGGCCACCATC
ACCCGGGAGCCGGTCGGCGTGGTCGGCGCCGTGGTGCCGTGGAACTTCCCGCTGATGCTCGCCACCTGGAAGATCGCACC
GGCGCTGGCGACCGGCAACGCGGTGGTGGTCAAGCCGGCGGAGCAGTCCCCGCTCACCGCGCTGCGCTTCGCCGAGCTGG
CCGCCGAGGCGGGGGTGCCCGACGGCATCCTCAACGTCGTCCCCGGGTTCGGCCCGACCGCGGGCGCGGCCCTGGGCCGC
CACCCGGACGTGGACGTGCTCACCTTCACCGGCTCCGGCGAGGTCGGCCGCCTGTTCATGCGGTACTCGGCCGAGTCCAA
CCTCAAGCAGGTCTCCCTGGAGCTCGGCGGCAAGTCCCCGCAGGTGGTGCTGCCCGACGCCCCCGACCTCAAGGTGGTCG
CCAAGGCGATCGCCACCGGCATCTACTTCAACCAGGGCGAGGTGTGCTCGGCCGGATCCCGGCTGCTCGTCCACCGCGAC
ATCAAGGACGAGCTGCTCGAGCTCGTCCTGGAGGAGAGCCGCCGCATCGTGGTCGGCGACCCGCTCGACCCGCGGACCGG
CGTCGGCGCGCTGGTGGAGGAGAAGCACCTCGACCGGGTCCTCGGGTACGTGCACGGCGCGATCGAGGAAGGCGCCGAGA
GGCTGCTCGGCGGCAACCGGATCCTGGAGGAGACCGGCGGCTACTACATGGAGCCGACCGTCTTCGACCGGGTCACCCCG
GGGATGCGGATCGCCCGCGAGGAGGTGTTCGGCCCCGTGCTCGCGGTGCTCACCTTCGACGACCTCGACGAGGCCGTGCG
CATCGCCAACGGCACCGACTACGGGCTCGCCGCGGCGGTGTGGACGCGGGACCTGTCGACCGCGCACCGCATGGCCCGGG
CGATCAGGGCCGGCACGGTCTGGGTGAACTGCTACGACGACAGCGACATCACCGTGCCGTTCGGCGGCTACGCCCAGTCC
GGGTTCGGCCGGGACAAGTCCCTGCACGCCCTGGAGAAGTACACCCAGCTCAAGTCGACATGGATCAAGCTGTGA

Protein sequence :
MTVIPEAEARARREELEKRFAGLSFPTRLFIDGRYVDAASGATLDRISPRNGKLIAKVAAGDEEDIDRAVAAARRAFESG
RWSGLHPRERRKVLQRLARLVEEHAEELALLESVDMGKPFTDALAVDIRVTVQCLDFYAEAVDKLYDEVAPTGPDVLATI
TREPVGVVGAVVPWNFPLMLATWKIAPALATGNAVVVKPAEQSPLTALRFAELAAEAGVPDGILNVVPGFGPTAGAALGR
HPDVDVLTFTGSGEVGRLFMRYSAESNLKQVSLELGGKSPQVVLPDAPDLKVVAKAIATGIYFNQGEVCSAGSRLLVHRD
IKDELLELVLEESRRIVVGDPLDPRTGVGALVEEKHLDRVLGYVHGAIEEGAERLLGGNRILEETGGYYMEPTVFDRVTP
GMRIAREEVFGPVLAVLTFDDLDEAVRIANGTDYGLAAAVWTRDLSTAHRMARAIRAGTVWVNCYDDSDITVPFGGYAQS
GFGRDKSLHALEKYTQLKSTWIKL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 1e-118 56
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-76 42
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 5e-78 42
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 5e-78 42
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 5e-78 42
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-77 42
hpaE AAO17179.1 HpaE Not tested tcd island Protein 2e-68 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tbis_1741 YP_003652347.1 betaine-aldehyde dehydrogenase VFG0082 Protein 6e-77 42