Gene Information

Name : Tbis_1552 (Tbis_1552)
Accession : YP_003652160.1
Strain : Thermobispora bispora DSM 43833
Genome accession: NC_014165
Putative virulence/resistance : Virulence
Product : urease
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 1784816 - 1786489 bp
Length : 1674 bp
Strand : -
Note : PFAM: amidohydrolase; Urease alpha-subunit domain protein; Amidohydrolase 3; KEGG: aeh:Mlg_0184 urease subunit alpha

DNA sequence :
GTGAACCGGAGTGAGTATGCCGCGGTGTACGGGCCGACCACCGGGGACCGGATCGTGCTCGCCGACACCGGGCTGGTGGT
GGAGGTCGAGGCGGACGCCCAGCGGCGCGGGGAGGAGTTCCTCGCCGGGTTCGGCAAGACGGCCCGGGACGGGCTCCACC
TCAAGGCCGCCTCGGTGCGGGAGACCTGCGACCTGGTCGTGTCGAACGTGGTGATCATCGACCCGGTGCTCGGCGTGCGC
AAGGCGTCGATCGGCATCCGGAACGGCCGGATCACCGCGATCGGCCGGGCCGGCAACCCGGACACCCTCGACGGGGTCGA
CGTGGTGGTCGGCACCGGGACCACGATCATCAGTGGCGAAGGGCTCATCGCCACCCCGGGGGCGATCGACACCCACGTGC
ACCTGATCTCCCCGCGGGTGATGGAGGCGTCGCTCGCGTCCGGGGTGACCACCATCCTGGGCCAGGAGTTCGGCCCGGTG
TGGGGCGTCGGGGTGAACTCGCCGTGGGCGTTGCGGACCGCGTTCGCCGCCTTCGACGCCTGGCCGGTCAACATCGGGTT
CCTGGCGCGGGGCTCGTCCTCCCGCCCGGAGCCGCTGGTCGAGGCCCTGGCCGAGGGAGGCGCCTGCGGGTTCAAGGTGC
ACGAGGACATGGGCGCCCACGCCCGGGCGCTCGACACCGCGCTGCGGGTCGCCGAGGAGCACGACGTCCAGGTCGCGCTG
CACACCGACGGCCTGAACGAGAGCCTGTCGGTGCGGGACACCCTCGCCGTGCTGGACGGGCGGACCATCCACGCCTTCCA
CGTCGAGGGGTGCGGGGGCGGGCACGTGCCGGACGTGCTCACCCTGGCCGGCCGGCCGAACGTCATCGGCTCCTCCACCA
ACCCGACGCTGCCGTTCGGCCGGGACGCCGTGGCCGAGCACTTCGACATGATCGTCTCCTGCCACGGGCTCTCTCCGGAC
CTGCCCAGCGACCAGGCGCTGGCCCGCGACCGGATCCGGGCGCAGACCATGGCCGCGGAGGACGTGCTCCACGACCTCGG
CGTCATCCCGATCACCTCCTCCGACGCCCAGGGCATGGGCCGGGCCGGGGAGACGATCCGGCGGACCTTCGCCCTCGCCG
GGAAGATGAAGGCCGAGCGCGGGCCGGAGCACGAGCGGCACGACAACGCGCGGGTCCTCCGCTACCTGGCCAAGCTCACC
ATCAACCCCGCGCTGGCGCACGGCCTCGCCCACGAGATCGGCTCCCTGGAGCCGGGCAAGCTCGCCGACATCGTTTTGTG
GGAGCCCGCCCGGTTCGCCGCCGTCCCGCGCCTGGTGCTCAAGGCTGGCTTCCCCGCCTGGGGCGTGACCGGGGACCCGA
ACGCGGCGGTGGAGCACGCGCAGCCGCGCGTCATGGGGCCGCAGTTCGGCGGCCACGGGGCCGCCCCGGCCGAGATCGCC
GTCGCCTTCGTCAGCCGGTCGGCCCTCGACGCCGGCCGGGACCGGCTCCCCACCCGCCGCCGCCGCGTGGCCGTACGGAA
CACCCGCGGCATCGGGCTGGCCGATATGGTGCATAACGGACGAATTGGAACAGTGCACGTCGATCCCGCCACCGGCGCCG
TGGACCTGGACGGCGAGCCCCTCACCTCCACCCCGGCCGAGCGCGTCCCCCTCTTCCGCCTCTACCACCTCTGA

Protein sequence :
MNRSEYAAVYGPTTGDRIVLADTGLVVEVEADAQRRGEEFLAGFGKTARDGLHLKAASVRETCDLVVSNVVIIDPVLGVR
KASIGIRNGRITAIGRAGNPDTLDGVDVVVGTGTTIISGEGLIATPGAIDTHVHLISPRVMEASLASGVTTILGQEFGPV
WGVGVNSPWALRTAFAAFDAWPVNIGFLARGSSSRPEPLVEALAEGGACGFKVHEDMGAHARALDTALRVAEEHDVQVAL
HTDGLNESLSVRDTLAVLDGRTIHAFHVEGCGGGHVPDVLTLAGRPNVIGSSTNPTLPFGRDAVAEHFDMIVSCHGLSPD
LPSDQALARDRIRAQTMAAEDVLHDLGVIPITSSDAQGMGRAGETIRRTFALAGKMKAERGPEHERHDNARVLRYLAKLT
INPALAHGLAHEIGSLEPGKLADIVLWEPARFAAVPRLVLKAGFPAWGVTGDPNAAVEHAQPRVMGPQFGGHGAAPAEIA
VAFVSRSALDAGRDRLPTRRRRVAVRNTRGIGLADMVHNGRIGTVHVDPATGAVDLDGEPLTSTPAERVPLFRLYHL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-93 47
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 3e-95 47
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 3e-95 47
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-93 47
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-93 47
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-93 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tbis_1552 YP_003652160.1 urease VFG0270 Protein 4e-91 45