Gene Information

Name : Tbis_1461 (Tbis_1461)
Accession : YP_003652072.1
Strain : Thermobispora bispora DSM 43833
Genome accession: NC_014165
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1655828 - 1657252 bp
Length : 1425 bp
Strand : +
Note : KEGG: mxa:MXAN_6299 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta

DNA sequence :
GTGAATCGTCGAGCGAAGATTGTCTGTACCCTCGGTCCCGCCAGCTCCTCACCGGAGCGTCTGCGCGAGCTGATCGCCGC
GGGCATGGACGTGGCTCGCTTCAACCTGTCCCACGGAACGCAGGAGCTGCACAAGGAGGTCTTCGACCGGGTCAAGGCCG
CGGCCGCCGAGGTCGGCCGCGCCGTGGGCGTCCTCGCCGACCTCCAGGGCCCCAAGATCCGGGTGGGCAAGTTCGCCACC
GGTCCGGTACGGCTCAGCTACGGCGACATCTTCACGATCACGACCGAGGACGTCCCGGGCAACCGGGACATCGTCTCCAC
CACCTACAAGGGCCTGCCCGGGGACGTGAAGCCGGGCGACACGATCCTCGTCGACGACGGCCGCCTCAACCTCGAGGTCA
TCGACGTGGACGGGCCGCGCGTGATCACGAAGGTGCTCGTCGGCGGGATGATCTCCGACAACAAGGGGCTCAACCTGCCC
GGTGTGGCGATCAGCGCGCCGGCCCTCACCGAGAAGGACGAGGCCGACCTGCGCTGGGCGCTGCGCACCGGGTTCGACAT
CATCGCCCTGTCGTTCGTCCGGTCGCCGGACGACGCCGACCTCGTCCGGAAGATCATGGACGAGGAGGGCATCCGCGTCC
CGCTGCTCGCCAAGATCGAGAAGCCTCAGGCGGTCGAGCGGCTCGAGGAGATCGTCGACGCCTTCGACGGGATCATGATC
GCCCGGGGTGACCTCGGCGTGGAGCTCCCGCTCGAGCAGGTGCCGATCGTCCAGCGCCGGATCATCGAGCTGTGCCGGGA
GAAGGCGCACCCGGTCATCGTGGCCACCCAGATGCTGGACTCGATGATGCACTCCCCGCGGCCGACCCGGGCGGAGGCCT
CCGACGTGGCCACCGCGGTCATGCAGGGCGCCGACGCGGTCATGCTCTCCGGGGAGACCTCGGTCGGGAACTACCCGGTC
GAGGCCGTGACCACGATGCACCGGATCGCGGTGGCGACCGAGAGCGTCACCCTGAAGGCCACCCACACCCTCGACCGGCT
GCCCGAGACCACCGGCGGCGCCATCGCCCGCGCCGCGGCCGAGGTCGGCGCGATCGTGAAGGCCAAGGCGCTCGTGGCGT
TCACCATGTCGGGCGAGACCGCGCGCCGGCTCGCGCGCTACCGGTCCCCGATCCCGCTGCTCGCCTTCACCTCGAACCCC
AAGGCGCGCGGGCAGCTCGCGCTCACCTGGGGCGTGGAGACCTTCGAGGTGCCGTTCGTCCACCACACCGACGACATGGT
CCGCCAGGTCGAGGCGGCGCTGCTCTCCATGGGCCGGTGCCAGAAGGGCGACAAGGTGGTGATCGTCGCCGGCTCACCGC
CCGGCACGCCGGGCACCACCAACAACCTGCGGGTGCACACGATCGGCGCGGCCGTCTCGCGCTGA

Protein sequence :
MNRRAKIVCTLGPASSSPERLRELIAAGMDVARFNLSHGTQELHKEVFDRVKAAAAEVGRAVGVLADLQGPKIRVGKFAT
GPVRLSYGDIFTITTEDVPGNRDIVSTTYKGLPGDVKPGDTILVDDGRLNLEVIDVDGPRVITKVLVGGMISDNKGLNLP
GVAISAPALTEKDEADLRWALRTGFDIIALSFVRSPDDADLVRKIMDEEGIRVPLLAKIEKPQAVERLEEIVDAFDGIMI
ARGDLGVELPLEQVPIVQRRIIELCREKAHPVIVATQMLDSMMHSPRPTRAEASDVATAVMQGADAVMLSGETSVGNYPV
EAVTTMHRIAVATESVTLKATHTLDRLPETTGGAIARAAAEVGAIVKAKALVAFTMSGETARRLARYRSPIPLLAFTSNP
KARGQLALTWGVETFEVPFVHHTDDMVRQVEAALLSMGRCQKGDKVVIVAGSPPGTPGTTNNLRVHTIGAAVSR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 1e-67 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-67 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-67 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 3e-67 42
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 9e-60 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tbis_1461 YP_003652072.1 pyruvate kinase VFG0479 Protein 5e-68 42