Gene Information

Name : Tpau_4331 (Tpau_4331)
Accession : YP_003649231.1
Strain :
Genome accession: NC_014159
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 95049 - 96701 bp
Length : 1653 bp
Strand : +
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: rop:ROP_23290 2,3-dihydroxybenzoate-AMP ligase

DNA sequence : 
GTGGAGCGTAACCCCCTTAGGGGAGCCTGGGCTAATCTCAACGATGTGACATTCGTATCTCCCAGCGCGGCCGACTTCGT
GAATCTGCCCCCTCAGCAGCGGCGACGCTATGTCGAGGCGCGCCTGTACGAGGGGCTCCCGTTGTGGAGCGCGATCCTCG
GAACCGGACGGACCGACCCGTCGCTACCCGCCGTCCTCGACGAAGAGCGCTCCCTCACCCGCGCAGAACTCGACTCCGCG
TCCGCGGCGCGCGCCGCCGGCTTCGCCGGCGAATTCGCCCCCGGCGATGTGGTGGTGCTGCACCTGCCGAACACCGTCGA
GTTCGTCGTCACCCTCCTGGGGCTGCTCCGCGCCGGAGTGCTGCCGGTGATGGCACTGCCCGCGCACCGGATCGCCGAGA
TCGAACACCTCGCGGCCACCTCCGGCGCCGTCGGTTACATCTGCGCGGACGACCGGACCGGCTACGACTACCGCGATCTG
GGCACCGAGCTGCGCGGCCGGGTGCCCGCCGTCCGTTCCGTCCTGGTCGACGGTGCCCCCGGCCCCCACCGGGCGCTCGT
CGACGGTGCACCGTCGGACAGCCCGGACGTGCGGCCCGATCCCACGACACCCGCACTGTTCCTGATCTCCGGCGGCACCA
CGGGCGCGCCGAAGCTCATCCCGCGCACGCACGAGGACTACCTGTACAACGCCCGTACGGCCGCCGCGGTGTGCGGGCTC
GGCCCGGACGACGTGTATCTGGTCGCACTGCCCGCAGCGCACAACTTCCCCCTGGCCTGCCCGGGCCTGATCGGCGCGTT
GCTCACCGGCGGCCGCGTGGTGCTCACGCGCGATCCGAGCCCCGACTCCGCGCTGGAGCTGATCGAGCAGCACCGCGTGA
CGGTGACCGCGCTGGTCCCGGCGTTGGCGCAGCTGTGGACCGCCGCGCGGGCCTGGGAGAGCGCGGACGTGACGAGTCTG
CGACTGCTCCAGGTCGGTGGGGCGAAGCTCGCCGAGCCCGACGCCCGCGCCGCACAGGAGGCCTTCCCCGGCACCCTGCA
GCAGGTCTTCGGCATGGCCGAGGGGCTGATCAACCTCACCCGGATCGGCGCGGACCCGGACGTCGTCGCCACCACGCAGG
GCATTCCGATGAGCCCGTTCGACGAGCTGCGGGTGGTCGATGAGGACGGCGAGGACGTGCCCGAGGGCACCGTCGGCGAG
CTACTGACCCGTGGCCCGTACACGATCCGCGGCTATTACCGGGCCGGTGCCGCGAACCGGCGCGCGTTCACCTCCGACGG
CTTCTACCGGTCCGGCGATCAGGTGCGGATCCGGCCGGACGGCTCGATCGAATACGTCTCACGCATCAAGGAGACCATCG
TGCGCGGCGGGGAGAACATCTTCCCCGACGACATCGAGGAGGCCCTGCTCGCGCACCCGGCGGTCCGCGAGGCCGGGGTG
ATCGGACTCCCGGACCCCGTGCTGGGGGAGCGGACCTGCGCCGTGCTCGTCACGGACGGGCGGCTGCTCACCCTGGCCGA
GGTCAGGGACCATCTCACCGGCCGGGGTCTCGCGGCGTTCAAGCTGCCGGACCGGGTGCGGGTCATCGACGACCTGCCGC
TCACCGCGGTCGGGAAAGTGGACAAGAAGGCGTTGCGCGGCCTGCTCAGATGA

Protein sequence : 
MERNPLRGAWANLNDVTFVSPSAADFVNLPPQQRRRYVEARLYEGLPLWSAILGTGRTDPSLPAVLDEERSLTRAELDSA
SAARAAGFAGEFAPGDVVVLHLPNTVEFVVTLLGLLRAGVLPVMALPAHRIAEIEHLAATSGAVGYICADDRTGYDYRDL
GTELRGRVPAVRSVLVDGAPGPHRALVDGAPSDSPDVRPDPTTPALFLISGGTTGAPKLIPRTHEDYLYNARTAAAVCGL
GPDDVYLVALPAAHNFPLACPGLIGALLTGGRVVLTRDPSPDSALELIEQHRVTVTALVPALAQLWTAARAWESADVTSL
RLLQVGGAKLAEPDARAAQEAFPGTLQQVFGMAEGLINLTRIGADPDVVATTQGIPMSPFDELRVVDEDGEDVPEGTVGE
LLTRGPYTIRGYYRAGAANRRAFTSDGFYRSGDQVRIRPDGSIEYVSRIKETIVRGGENIFPDDIEEALLAHPAVREAGV
IGLPDPVLGERTCAVLVTDGRLLTLAEVRDHLTGRGLAAFKLPDRVRVIDDLPLTAVGKVDKKALRGLLR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-96 47
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 8e-97 47
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-96 47
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-96 47
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-96 47
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-96 47
ybtE CAA21394.1 - Virulence HPI Protein 1e-96 47
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 5e-96 46
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-96 46
irp2E YP_005134497.1 siderophore biosynthetic protein Virulence Not named Protein 7e-76 43
irp2E YP_005163485.1 siderophore biosynthetic protein Virulence Not named Protein 9e-76 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tpau_4331 YP_003649231.1 AMP-dependent synthetase and ligase VFG1817 Protein 6e-111 55
Tpau_4331 YP_003649231.1 AMP-dependent synthetase and ligase VFG0168 Protein 3e-91 47
Tpau_4331 YP_003649231.1 AMP-dependent synthetase and ligase VFG0932 Protein 2e-82 42