Gene Information

Name : Tpau_3409 (Tpau_3409)
Accession : YP_003648332.1
Strain : Tsukamurella paurometabola DSM 20162
Genome accession: NC_014158
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 3498061 - 3499758 bp
Length : 1698 bp
Strand : -
Note : TIGRFAM: urease, subunit alpha; KEGG: sgr:SGR_236 urease subunit alpha; PFAM: amidohydrolase; Urease alpha-subunit domain protein

DNA sequence :
ATGCGCATCGACCGCGAGCGCTACGCCGCGATCTACGGACCCACCGCGGGCGATCAGGTGCGCCTCGCCGACACCGACTT
GTGGATCGAGATCGAGAAGGATCACACCGTCGGCGGCGAAGAGGCCGTGTTCGGCGGCGGCAAATCGATCCGCGAATCCA
TGGCCCAGTCCGCCGTCACCCGCGCGCAGGGCGCGCTGGACACCGTGATCACCAACGCGATCCTCCTGGACTGGTGGGGC
ATCGAGATCGCCGACGTCGGAATCCGCGACGGCCGGATCGTCGCGCTGGGCCGGGCCGGAAACCCCGACGTGGCCGACGG
TGTGCACCCGGATCTGGTGATCGGGCCGTCGACCGACGTGATCTCCGGCGAGGGCAAGATCCTCACCGCCGGCGCCATCG
ACTCGCATGTGCACCTGCTCTCGCAGTCCCAGCTGCACGAGGCACTGTGCACCGGTATCACCACGGTGGTGGGCGGAGGC
ACCGGTCCGTCGGAGGGCTCCAAGGCGACCACGGTGACCCCCGGCGCCTGGCATCTGGCTGCGATGCACCGTGCGCTGGA
CGGTATTCCGTTGAACATCCTGCTGCTGGCCAAGGGCAACACCGTCTCCGCGGAGGCTCTCAGGGAACAGGCCCTCGGTG
GCGCCGCCGGATACAAGGTGCACGAGGACTGGGGCTCGACCCCGGCCGCGATCGACGCCGCCCTGCGCGCCGCGGACGAC
TGGGGCCTCCAGGTCGCGCTGCACTCCGACTCGCTCAACGAGGCGGGCTTCGTGCAGTCCACGATCGATGCCATCGCGGG
CCGCTCGATCCACGCTTTTCACACCGAGGGCGCCGGCGGCGGACACGCGCCCGACATCCTCACCGTGGCCTCGCTGCCGC
ATGTGCTGCCCGGCTCCACCAACCCGACGCTGCCGCACACGGTGAACACCGTGGCCGAACACCTCGACATGCTCATGGTG
TGCCACCACCTCAATCCCGCCGTGCCGGAAGACCTCGCGTTCGCCGAATCCCGCATCCGCGCCACCACGATCGCTGCCGA
AGACGTGCTGCACGATATGGGCGCGCTGTCGATCACCAGCTCCGACGCGCAGGCGATGGGCCGGATCGGTGAGGTGGTGT
GCCGCACCTGGCAGGTGGCGCACGTGATGAAGCACCGCCGTGGCAGCCTCGGCGGCGCTGCCGACAACATCCGTGCCAAG
CGGTACGTCGCGAAGTACACGATCAATCCCGCTGTGGCGCATGGTATCGACCACGAGATCGGCTCGGTGGAGTCGGGCAA
GATGGCCGACCTTGTGCTGTGGGACCCTCGCTTCTTCGGCATCCGGCCCGAGGTGGTGGTCAAGGGCGGCGCATTGGTGT
GGGCCGCGCTCGGCGACCCGAACGCCTCGATCCCCACGCCGCAGCCGGTGCTCATGCGCCCCACCTTCGGCGCCGACGCC
GGAGCCGATCACGCCGTCACCTTCGTCTCACCCGCGGCCCTCGACGACGGCCTCGCCGATCGGCTCGGGTTGCGCCGCAG
GCTACTTCCGCTCGCGCCCACCCGCGCGGTCACCAAGGCGCAGATGCTGGGCGGCAACGATGCACTGCCCGATATCCGAG
TCGAGCCCGATACGTTCCGGATCACCGTCGACGGTGACGAGATCCTGCCCGCTCCCGCCGCCGAGCTGCCACTCGCACAG
CTGTACTCGATGTTCTGA

Protein sequence :
MRIDRERYAAIYGPTAGDQVRLADTDLWIEIEKDHTVGGEEAVFGGGKSIRESMAQSAVTRAQGALDTVITNAILLDWWG
IEIADVGIRDGRIVALGRAGNPDVADGVHPDLVIGPSTDVISGEGKILTAGAIDSHVHLLSQSQLHEALCTGITTVVGGG
TGPSEGSKATTVTPGAWHLAAMHRALDGIPLNILLLAKGNTVSAEALREQALGGAAGYKVHEDWGSTPAAIDAALRAADD
WGLQVALHSDSLNEAGFVQSTIDAIAGRSIHAFHTEGAGGGHAPDILTVASLPHVLPGSTNPTLPHTVNTVAEHLDMLMV
CHHLNPAVPEDLAFAESRIRATTIAAEDVLHDMGALSITSSDAQAMGRIGEVVCRTWQVAHVMKHRRGSLGGAADNIRAK
RYVAKYTINPAVAHGIDHEIGSVESGKMADLVLWDPRFFGIRPEVVVKGGALVWAALGDPNASIPTPQPVLMRPTFGADA
GADHAVTFVSPAALDDGLADRLGLRRRLLPLAPTRAVTKAQMLGGNDALPDIRVEPDTFRITVDGDEILPAPAAELPLAQ
LYSMF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 2e-138 58
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 2e-138 58
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-133 55
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-133 55
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-133 55
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-133 55

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tpau_3409 YP_003648332.1 urease subunit alpha VFG0270 Protein 6e-125 55