Gene Information

Name : Tpau_3151 (Tpau_3151)
Accession : YP_003648077.1
Strain : Tsukamurella paurometabola DSM 20162
Genome accession: NC_014158
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 3259894 - 3261066 bp
Length : 1173 bp
Strand : -
Note : KEGG: rha:RHA1_ro05845 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase

DNA sequence :
ATGAGTGAGCAGAAGAGCGCCATCGACAAGCATGCGGCGCAGGGCTTCTCGACCCGCGCGATCCACGCCGGCTACGAGCC
CGACCCGCTGACCGGCGCCGTCAACGTGCCGATCTACGCCAGCTCCACCTTCGCCCAGGACGGCGTCGGCGGCATGCGCG
GCGGATTCGAGTACGCCCGCACCGGCAACCCGACCCGGCGCGCCTACGAGGCCAACCTCGCCGCGATCGAGGACGGCACC
TTCGGTCGCGGTTTCGCCTCCGGTATGGCCGCCACCGACACCCTGCTGCGCGCCACGCTCCGCCCCGGAGATCACCTGAT
CATCCCGGACGATGCGTACGGCGGCACCTTCCGCCTGATCGATAAGGTCTTCTCGCAGTGGGGGATCGAGCACACCCCGG
CACCCGTCACCGACGTCGACGCCGTGCGGGCGGCGATCCGCCCGAACACCAAGCTGGTGTGGATCGAGACGCCGACCAAC
CCGCTGCTCAACATCGGCGATATCGCCGCGCTCGCCGAAGTGGCGCACGCCGGTGGCGCGAAGCTGGTGGTGGACAACAC
CTTCGCCAGCCCGTACCTGCAGACGCCGCTCACCCTGGGCGCCGATGTGGTGTTGCACTCGGTGACCAAGTACCTGGGCG
GGCACAGCGACACCGTGGGCGGCGCGCTGATCACCAACGACGAACAGCTCGACACCGACTTCGCGTTCCTGCAGAACGGC
GCTGGCGCGGTGCCCGGCCCGTTCGACGTCTACCTCGCGCTGCGCGGAATCAAGACGCTCGGCGTCCGGATGGACCGGCA
CTGCGATAACGCGGAGCGGATCGTCGACTTCCTCTCCGGCCGCCCCGAGGTGTCGACGGTGCTGTACCCGGGCCTGGAGA
GCCACCCGAACCACGCGGTAGCGGCCAAGCAGATGAAGCGCTTCGGCGGCATGATCTCCGTGCGCCTGGCCGGCGGCCGC
GAGGCCGCGCAGCGATTCTGCGCGCGGACCGAGGTCTTCACCCTCGCCGAATCGCTCGGTGGCATCGAGTCGCTCATCGA
GCATCCCGCCGCGATGACCCACGCGTCCACGGCCGGTTCGCAGCTCGAGGTGCCGGAGGATCTGGTGCGGCTGTCGGTGG
GCATCGAGGACATCGGCGATCTCATCGCCGATCTGGAGAACGCGCTCGGTTAG

Protein sequence :
MSEQKSAIDKHAAQGFSTRAIHAGYEPDPLTGAVNVPIYASSTFAQDGVGGMRGGFEYARTGNPTRRAYEANLAAIEDGT
FGRGFASGMAATDTLLRATLRPGDHLIIPDDAYGGTFRLIDKVFSQWGIEHTPAPVTDVDAVRAAIRPNTKLVWIETPTN
PLLNIGDIAALAEVAHAGGAKLVVDNTFASPYLQTPLTLGADVVLHSVTKYLGGHSDTVGGALITNDEQLDTDFAFLQNG
AGAVPGPFDVYLALRGIKTLGVRMDRHCDNAERIVDFLSGRPEVSTVLYPGLESHPNHAVAAKQMKRFGGMISVRLAGGR
EAAQRFCARTEVFTLAESLGGIESLIEHPAAMTHASTAGSQLEVPEDLVRLSVGIEDIGDLIADLENALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-73 47
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-74 47
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 8e-60 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tpau_3151 YP_003648077.1 cystathionine gamma-synthase BAC0207 Protein 2e-67 44