Gene Information

Name : TherJR_0444 (TherJR_0444)
Accession : YP_003639227.1
Strain : Thermincola potens JR
Genome accession: NC_014152
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 452479 - 454548 bp
Length : 2070 bp
Strand : +
Note : KEGG: pth:PTH_0233 cation transport ATPase; TIGRFAM: heavy metal translocating P-type ATPase; cadmium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Heavy metal tran

DNA sequence :
ATGGACTGCGCCGCCAAGTTTGAAAAAGAAGTGGCGGCCATACCTGGTGTCACCAGGGCAGAGCTTAACTTTGGCGCTTC
CAAATTAACCGTGCAGGGGGCTTTTGACCCGCAGGCCGTTTACTTGGCAGGAACCAGGCACGATATTGTTGCGCGGCCGG
CATATGAAAAAGGACAGGAAAAACAGTCTTTCTTTGCTGAATACAAAAGGGTTATCATCAGCGGGCTGGCGGGGTGCGCT
CTGCTTTCCGGTTGGGTGCTACAGCACACCCAAGGATTAACTTCCGCTGCCATTCTCTTGTATATTGCAGCTATGGTAAT
CGGTGGATTTTCCACTGCCAGAAAAGCCTTTTTCAGTATCCGGAAACTTAATTTTGACATGAATGTACTAATGACCATCG
CGGTAATTGGAGCAGCGGCTATAGGCGAATGGTCAGAAGGGGCCTCGGTGGCTTTCCTTTATTCCATCTCCAATGCCCTG
GAATCCTTCACCATGGAAAAAGCCCGGCAATCTATTAGAGAACTTATGGACATTGCGCCGCGGGAAGCGCTGGTCAGGAG
AAACGGGGAAGAAATTTGTTTAGCGGTGGATGAAATTCGTGTTGGCGATATATTGATTGTTAAACCAGGCGCAAAAATTG
CCATGGACGGCAAAGTCATTAAGGGAACTTCAGCCGTTAACCAGGCCGCTATCACCGGCGAATCTGTTCCCGTGGAAAAA
AACGTCGGTGATGAAGTCTTTGCCGGTACTTTGAACCAGGAAGGTGCCATTGAGGTGGAGGTCACCAAGCTGGTAAACGA
TACAACCATCGCGAAAATAATTCATATGGTAGAAGAAGCCCAGGCCCAAAGAGCCCCTTCCCAGAAGTTTATTGACCGTT
TTGCCGCCGTTTATACGCCTATAGTCATCGCTCTGGCCATCGGAGTGGTCTTAATACCGCCCCTTGTTTTTGGCCGGCCG
TGGAGTCCCTGGATATACAGGGGTTTAGCCCTGCTGGTGGTTTCCTGTCCCTGTGCGCTGGTGGTATCCACGCCTGTAGC
CCTGGTTTCGGCCATAGGCAATGCGGCGCGTAACGGTGTGCTGATTAAAGGCGGTGTGCACCTGGAGGAAATGGGCTCAG
TAGCCGTTATTGCCTTTGATAAAACAGGTACCCTGACTGTCGGCCGGCCGGCGGTTATCGACATAATTCCCGTCACCGCC
AAAGATGAAAAGCAGGTATTGAACCTGGCCGCAAGTATTGAACAGTTTTCGGAACACCCCCTGGCTAAAGCCATCGTAGA
AAAGGCCAGGCAGGAAAAACTGGCGTTGTTACCGGTCGAAGATTTCACCTCCCTCACAGGAAAAGGCGCCAGAGCTAAAG
TAAAAGGAAAAAGGTATTTTATCGGCAATCCACGTCTATTAGACGAATTAGGCATGCAAACAAAAGAAACCGGACAGGTT
GTCGCGCAGTTACAGGAACAGGGTAAAACAGTGATGGTGGTGGGGGACGAAGAAAATATCGTGGGGATAATAGCAGTGGC
TGATATTGTCAGGGAATCAGCCGCCAGGACTATCAGGGAATTGAAGCAGGCCGGTTTAAGGCGGGCCGTAATGTTGACCG
GAGATAATAAAGCCACGGCCAAAGCTATTGCTGAGAAGGCGGGCATTGATGAGTTTCATGCCGAATTACTGCCGCAGGAT
AAAGTAGCCGCCGTGAATAACCTGGTTAATAAGTTTGGTAAAGTAGCTATGGTTGGCGATGGGATAAATGATGCGCCGGC
TCTGGCGGCAGCAACCGTGGGGATAGCTATGGGCGGGGCCGGTACGGATACGGCGCTGGAAACCGCCGATATCGCCCTGA
TGGCCGATGACCTGGCCAAGCTGCCTTTCCTGGTGCGCCTGAGCAGAGCTACTCTCAGTGTTATCAAACAAAATATCTAT
TTTGCTGTGGTTATTAAATTGATTGCCGTGGTCCTCATTTTCCCGGGCTGGTTGATGTTATGGATGGCCATACTGGCAGA
CACCGGGGCAGCAGTTCTGGTTACTCTCAACGCTATTAGGCTGCTGCGAATAAAACCTGAATTATATTAA

Protein sequence :
MDCAAKFEKEVAAIPGVTRAELNFGASKLTVQGAFDPQAVYLAGTRHDIVARPAYEKGQEKQSFFAEYKRVIISGLAGCA
LLSGWVLQHTQGLTSAAILLYIAAMVIGGFSTARKAFFSIRKLNFDMNVLMTIAVIGAAAIGEWSEGASVAFLYSISNAL
ESFTMEKARQSIRELMDIAPREALVRRNGEEICLAVDEIRVGDILIVKPGAKIAMDGKVIKGTSAVNQAAITGESVPVEK
NVGDEVFAGTLNQEGAIEVEVTKLVNDTTIAKIIHMVEEAQAQRAPSQKFIDRFAAVYTPIVIALAIGVVLIPPLVFGRP
WSPWIYRGLALLVVSCPCALVVSTPVALVSAIGNAARNGVLIKGGVHLEEMGSVAVIAFDKTGTLTVGRPAVIDIIPVTA
KDEKQVLNLAASIEQFSEHPLAKAIVEKARQEKLALLPVEDFTSLTGKGARAKVKGKRYFIGNPRLLDELGMQTKETGQV
VAQLQEQGKTVMVVGDEENIVGIIAVADIVRESAARTIRELKQAGLRRAVMLTGDNKATAKAIAEKAGIDEFHAELLPQD
KVAAVNNLVNKFGKVAMVGDGINDAPALAAATVGIAMGGAGTDTALETADIALMADDLAKLPFLVRLSRATLSVIKQNIY
FAVVIKLIAVVLIFPGWLMLWMAILADTGAAVLVTLNAIRLLRIKPELY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 1e-167 55
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-168 54
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-168 54

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TherJR_0444 YP_003639227.1 heavy metal translocating P-type ATPase BAC0298 Protein 3e-111 50
TherJR_0444 YP_003639227.1 heavy metal translocating P-type ATPase BAC0092 Protein 6e-103 43
TherJR_0444 YP_003639227.1 heavy metal translocating P-type ATPase BAC0461 Protein 7e-96 41