Gene Information

Name : cadA2 (THI_3120)
Accession : YP_003625503.1
Strain : Thiomonas sp. 3As
Genome accession: NC_014145
Putative virulence/resistance : Resistance
Product : Cadmium-transporting ATPase
Function : -
COG functional category : -
COG ID : -
EC number : 3.6.3.3
Position : 3041126 - 3043513 bp
Length : 2388 bp
Strand : +
Note : Evidence 2b : Function of strongly homologous gene; PubMedId : 10660539, 10858330, 11282588, 9339465; Product type t : transporter

DNA sequence :
ATGAGCCAGCACGACCCCACCAGCACAGCGTTACGCCTGCCTGTCCAGGCGCAAGACCATGAGCCCGCATGTGACCACGA
TCATGCGCACGATCATGGTCACGACCACGGCCCTGATGCGCATACCCATGCCCACGCGGCGGCCGATGCCTGCTGCGCCC
CAACGACACAGACCGACTGCCTCACGGGGGTGTGCAACACCAATCCGGCACCCGAAGGGACCAGCCGGGTGCGCTACCGC
ATCGACAAGATGGACTGCCCGACCGAGGAGCGCCTGATCCGCAACAAGCTGGAGGCCATGCCCGGGGTTGTGCAGCTCGA
CTTCAACCTCGTGAATCGGGAGCTCACGGTGTATCACCGCTTGGATCAGCCCCAGGAGATTGCCGTGGCGCTGGACAAGC
TGGGCATGGCACCCAATTTGCTGGAAGCCAATGCGCCGGTGTCCGTGCTTCCCCCCGCCCTGAGCCGAAGGCAAAAAGGT
CTGCTCGCCGTGGCTGGCGCCGCCGCCGTCGCGGCCGAGGTCATCGCCTGGTCGAGCGGGCAAGAAGCCTCGTGGATGGT
GATGGCGCTTGCCGCCGTGTCCATCCTCAGCGCCGGTCTGCCCACCCTCAAGAAGGGCTGGATCGCGCTCAGAAACCTGA
CCCTCAATATCAACTTCCTGATGTCCATCGCCGTGGCCGGGGCCGTGGCGCTCGGCAAGTGGCCGGAAGCGGCGATGGTG
GTGTTCCTGTTTGCCGTGGCCGAGGCGATCGAGGCGCTGTCGCTGGAGCGTGCCAGGAACGCGATCAAGGCGCTCACGGC
CATCGCGCCGGAAACTGCCGAGGTCAAGGCTGGCGAGGCCTGGGAGTCCAAGCCGGTGGCCGGGGTGGCGGTCGGCAGCC
GCATCCGGGTGCGCACCGGCGCGCGGGTGCCGCTGGACGCACGCGTCGACTCCGGCCGCGCGGCGCTGAACCAGGCGCCG
ATCACCGGGGAAAGCCTGCCCGTGGACAAGCAAGCGGGTGACCTGCTGTATGCCGGCAGCATCGTGGCCGATGGCGTGGT
GGAAGCCACCGTCACGGCCTCGGCTGGTGACAGCACCTTGGCCCGCATCGCCCTGGCCATCCAGAGCGCGCAGTCACAGC
GCGCGCCGACCCAGCGTTTCGTCGATCAATTCGCGCGCTACTACACCCCCGCGGTGGTGGTCTTCGCCATCGCCGTGGCC
ATCCTCGGCCCGCTGCTGAGCGGCGGCGGCTGGAGTTCCTGGCTGTACGAGGCCCTGGTCATGCTGGTCATCGCCTGCCC
CTGCGCCTTGGTGGTGTCGACCCCGGTCACGGTGGTCAGCGGCCTCGCGGCGGCGGCCCGGAGGGGCATCCTCATCAAGG
GCGGGGTGCATCTCGAAGGCGGCCGGCTGCTCAAAGCCGTGGCGCTCGACAAGACCGGCACGCTGACCCTCGGCAAGCCC
GCGCTGACCGATGCGATCCCGCTTGGCGATATGCCGATCGCGCAAGCCCTGCGGATCGCCGCCAGCCTCGATGACCACAG
CACCCATCCGGTCGCCCAGGCGCTGGTCGCCGGTTGGCGCGCGCAGCAGCCGGGCGCCGCAGTCATGCCTGTCGATGATT
TCGGCGTGCTGCAAGGGCGCGGCGTCAAAGGCAGCATGGACGGGCAGGTCTGGCATCTGGGCAATCACCGCCTGGCTGAA
GACATTGGGGTCTGTTCGGCCGCGCTGGAGGCGCAGCTTGCCGTGCTGGAGCGTGCCGGCAAGACCGCCATCGTTTTGTG
CGACGCGGTCGGCCCGGTGGCCGTGTTTGGCGTCGCCGACACCCTCAGGCCGGAGAGCGCGCAGGCCGTTGCGGCCCTCA
AGTCGCTGCATGTCGAACCCGTCATGTTGACCGGCGACAACCCGGCCACGGCACGGGCCATTGCCGTCCAGCTCGGCATC
AAGGATGCGCGCGGCAATCTGCTGCCGCAGGACAAGCAGGCCGCCGTTGCCGAACTGCATGCGCGCTACGGCTCGGTCGG
CATGGTCGGCGACGGCGTGAACGATGCGCCGGCGCTGGCACGCGCCAACATCGGCTTCGCCATGGGAGCGGCCGGCACCG
CCACCGCGCTGGAAACCGCCGATGTGGCCATCATGGACGACGACCCGCGCAAGATCGCCGACTTCATCCGCTTGAGCCGG
CACACCGCCATGATTCTCAAGCAGAACATCGCCCTGGCGCTCGGCATCAAGGCCGTGTTCTTCGTGCTGGCCCTGAGCGG
CGTGGCGACCCTGTGGATGGCGGTGTTCGCCGACATGGGGGCCAGCCTGCTGGTGGTGTTCAACGGCATGCGGCTGCTGC
GCCGGCGGAACGTGCAGCGGTTTGATTTGCTTGGTTCATGGTTTCACAACAAGGAGATGCCATCATGA

Protein sequence :
MSQHDPTSTALRLPVQAQDHEPACDHDHAHDHGHDHGPDAHTHAHAAADACCAPTTQTDCLTGVCNTNPAPEGTSRVRYR
IDKMDCPTEERLIRNKLEAMPGVVQLDFNLVNRELTVYHRLDQPQEIAVALDKLGMAPNLLEANAPVSVLPPALSRRQKG
LLAVAGAAAVAAEVIAWSSGQEASWMVMALAAVSILSAGLPTLKKGWIALRNLTLNINFLMSIAVAGAVALGKWPEAAMV
VFLFAVAEAIEALSLERARNAIKALTAIAPETAEVKAGEAWESKPVAGVAVGSRIRVRTGARVPLDARVDSGRAALNQAP
ITGESLPVDKQAGDLLYAGSIVADGVVEATVTASAGDSTLARIALAIQSAQSQRAPTQRFVDQFARYYTPAVVVFAIAVA
ILGPLLSGGGWSSWLYEALVMLVIACPCALVVSTPVTVVSGLAAAARRGILIKGGVHLEGGRLLKAVALDKTGTLTLGKP
ALTDAIPLGDMPIAQALRIAASLDDHSTHPVAQALVAGWRAQQPGAAVMPVDDFGVLQGRGVKGSMDGQVWHLGNHRLAE
DIGVCSAALEAQLAVLERAGKTAIVLCDAVGPVAVFGVADTLRPESAQAVAALKSLHVEPVMLTGDNPATARAIAVQLGI
KDARGNLLPQDKQAAVAELHARYGSVGMVGDGVNDAPALARANIGFAMGAAGTATALETADVAIMDDDPRKIADFIRLSR
HTAMILKQNIALALGIKAVFFVLALSGVATLWMAVFADMGASLLVVFNGMRLLRRRNVQRFDLLGSWFHNKEMPS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 6e-161 59
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 2e-97 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA2 YP_003625503.1 Cadmium-transporting ATPase BAC0298 Protein 1e-155 60