Gene Information

Name : merA2 (THI_3072)
Accession : YP_003625463.1
Strain : Thiomonas sp. 3As
Genome accession: NC_014145
Putative virulence/resistance : Resistance
Product : Mercuric reductase (Hg(II) reductase)
Function : -
COG functional category : -
COG ID : -
EC number : 1.16.1.1
Position : 3007231 - 3008898 bp
Length : 1668 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6530603, 8063107; Product type e : enzyme

DNA sequence :
ATGCAAACCCTGAGCATCAGCGGCATGACCTGCGACACCTGTGCCATGCATGTCAAGGACGTCTTGGAACAATTGCCCGG
GGTGAGATCCGCGCAGGTCTCGTACCCGCACGGCTCAGCCCAGGTTGTTGCCGATGCTGGGGTGTCGTTGGATGTCATGG
CGGCGGCCGTGTCCAAGGCCGGTTACTCGGCGAAACAAGCGACCCAGTCGCCCGAGGTGCCGAACGGCCAGCCCGGCGAC
ACCACCGGCCCTGCACGGCGCGGCGATGGCAGCGACCTGCGCATCGCCGTCATCGGCAGCGGCGGGGCGGCCATGGCGGC
GGCCATCAAGGCGGCCGGCAGCGGCGCGCAGGTCACGCTGATCGAGCGTGGCGTCATCGGCGGCACCTGCGTCAACGTCG
GCTGCGTGCCGTCCAAGATCATGATCCGCGCTGCGCACATCGCCCATCTGCGCCGCCGCAGCCCGTTCGACGCCGGCATC
CAGCCTTGTACGCCCACCATCCTGCGCGACAAACTGCTCGTGCAGCAGCAAGCGCGTGTGGACGAGCTGCGCCACGCCAA
GTATGAAAGCATTCTCGAAGGCCAGCCGGCCATCACCACCCTGCGCGGCAAGGCCAGCTTCAAAGACGCCCGGACGCTGG
TCGTGACGCTGCACGACGGCAGCGAGCGCAGGCTCGGATTCGACCGCTGCCTGATCGCCACCGGCGCCAGCCCGTCCATC
CCACCCATTGCGGGCTTGAGGGACACGCCATACTGGACTTCGACCGAGGCGCTGGAAAGCGACACGATTCCGCCGCGCCT
GGCGGTCATCGGTTCTTCTGTCGTGGCGCTGGAACTGGCCCAGGCCTTCGCCCGCCTGGGCAGCCAGGTCACCGTCCTGG
CGCGCCACACGCTGTTCTCGCAGGAAGATCCGGCCATCGGCGAAGCCGTTGCCGCCGCGTTCCGCGAGGAGGGCATCACC
GTCCTGACCCACACCCAGGCCAGCGCGGTGGCTCATGCCGGCGGCAGCTTCGCGCTGACCACGAACCATGGCGAGATTCG
GGCCGAGCGCCTGCTGGTGGCGACGGGCCGCGCACCCAACACGGCGGAGCTGAATCTGCCAGCCGCCGGCGTCAAGCTTG
ATACGCGCGGCGCGATTGTGGTGGATGACCATCTGCGTACCAGCGTGCCGCACATCTACGCCGCCGGGGACTGTACCGAT
CAACCGCAGTTCGTCTATGTGGCCGCAGCCGGGGGCACGCGTGCGGCCATCAACATGACCGGAGGCGATGCGACACTCGA
CCTCTCGGCCATGCCGGCCGTGGTGTTCACCGACCCGCAGGTGGCCACGGTGGGCCTGACCGAGGCCGAGGCGCAGCGCC
AAAACATCGAGACCGACAGCCGCACGCTGAGCCTGGAGAACGTGCCCAGAGCCCTGGCCAACTTCGACACGCGCGGCTTC
GTCAAGCTGGTCGCCGAAGCCGGCTCCGGACGACTGCTCGGCGTGCAGGCGGTGGCCGCCGAGGCCGGCGAACTCATCCA
GACGGCGGCACTGGCGATCCGCAACCGCATGACGGTGCAGGAACTGGCCGATCAGCTGTTTCCCTACCTGACCATGGTGG
AGGGGCTGAAGCTGGCCGCCCAGACCTTTACCAAGGATGTGACGCAACTGTCGTGTTGCGCGGGGTGA

Protein sequence :
MQTLSISGMTCDTCAMHVKDVLEQLPGVRSAQVSYPHGSAQVVADAGVSLDVMAAAVSKAGYSAKQATQSPEVPNGQPGD
TTGPARRGDGSDLRIAVIGSGGAAMAAAIKAAGSGAQVTLIERGVIGGTCVNVGCVPSKIMIRAAHIAHLRRRSPFDAGI
QPCTPTILRDKLLVQQQARVDELRHAKYESILEGQPAITTLRGKASFKDARTLVVTLHDGSERRLGFDRCLIATGASPSI
PPIAGLRDTPYWTSTEALESDTIPPRLAVIGSSVVALELAQAFARLGSQVTVLARHTLFSQEDPAIGEAVAAAFREEGIT
VLTHTQASAVAHAGGSFALTTNHGEIRAERLLVATGRAPNTAELNLPAAGVKLDTRGAIVVDDHLRTSVPHIYAAGDCTD
QPQFVYVAAAGGTRAAINMTGGDATLDLSAMPAVVFTDPQVATVGLTEAEAQRQNIETDSRTLSLENVPRALANFDTRGF
VKLVAEAGSGRLLGVQAVAAEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFTKDVTQLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 8e-175 73
merA AFG30120.1 MerA Not tested PAGI-2 Protein 8e-175 73
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-176 73
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-176 73
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 1e-174 73
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-176 73
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 2e-178 73
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 3e-173 73
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 7e-179 73
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 3e-169 70
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 5e-87 42
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 4e-87 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA2 YP_003625463.1 Mercuric reductase (Hg(II) reductase) BAC0652 Protein 3e-173 72
merA2 YP_003625463.1 Mercuric reductase (Hg(II) reductase) BAC0653 Protein 2e-172 71
merA2 YP_003625463.1 Mercuric reductase (Hg(II) reductase) BAC0650 Protein 8e-164 67
merA2 YP_003625463.1 Mercuric reductase (Hg(II) reductase) BAC0651 Protein 2e-87 42
merA2 YP_003625463.1 Mercuric reductase (Hg(II) reductase) BAC0224 Protein 4e-86 42