Gene Information

Name : metC (lpa_01344)
Accession : YP_003618169.1
Strain : Legionella pneumophila 2300/99 Alcoy
Genome accession: NC_014125
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 1057166 - 1058317 bp
Length : 1152 bp
Strand : -
Note : COG0626, MetC, Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]

DNA sequence :
ATGAATAAGACTCATTTCGATACACGTGCAATTCATGCTGGGCAAGAACCATGTCAAAGTACAGGGGCCGTGATGACCCC
TATTTATGCTACCTCCACCTATAAGCAAATTGCCCCTGGCGAACATCTTGGCTATGAATACTCACGCACCCAAAACCCCA
CCAGAAAAGCCTATGAGGATTGCATAGCAAGCCTTGAATCAGGCCAAAAAGGATTTGCGTTTGCTTCGGGCATGGCTGCA
ATCAATACGGTTATTGATTTATTAGATTCAGGAGATCACGTCGTTGCCATGGATGATCTTTATGGAGGAACTTTCCGGCT
TTTTGATAAAGTAAAAACCCGAACTTCTAATTTATCCTTTTCTTTTATTGATATGTCAGTACCCGAGAATATTGAGGCTG
CAATAACTCCGAAGACAAAATTACTATGGCTGGAAACCCCTTCCAATCCCATGCTAAAGCTAGCTAATTTACGAAAAATC
GCCGCTATTGCAAAAAAACATAATTTGATTACAGTTGCCGATAACACCTTTGCAACCCCCTGGATTCAACGCCCTCTTGA
GCTCGGATTTGACATTGTACTTCATTCAGCAACCAAATATCTGAACGGACATTCTGATGTAATCAGTGGTGTCGTTGTGG
TCGGTGACAATCCCATGTTGTCTGATAAAATTGCTTTTTTGCAAAATTCATGCGGCGCTGTAGCTGGCCCTTTCGACAGT
TTCCTGGTTCTGAGAAGCTTAAAAACATTATCTCTTCGTATGCAAAGGCACTGTGAAAATGCTAACCACCTGGCTAACTG
GCTTAACGGCCACCCCAAGATTGAAAAAGTCATTTATCCCGGATTAAAAAGTCATCCGCAATATTCTCTTGCCAAGGAAC
AAATGAACGATTTCGGTGGTATGATCTCTTTGGTACTTAAAGGTGGTCTTGAAGATGCCAAACGATTTTTAGCTCGCTGC
GAATTATTTACCTTGGCTGAAAGCCTGGGGGGTGTAGAAAGTTTAATTGAACACCCTGCAATTATGACCCATGCCTCTAT
TCCAGTCGAACAACGAAAAGCCCTGGGTATAGAAGATGGTTTCATAAGATTATCAGTTGGTATTGAACACATTGATGATC
TGCGTGCCGATCTGGAGCATGCTTTAGGTTAA

Protein sequence :
MNKTHFDTRAIHAGQEPCQSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLDSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKHNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVISGVVVVGDNPMLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSLRMQRHCENANHLANWLNGHPKIEKVIYPGLKSHPQYSLAKEQMNDFGGMISLVLKGGLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-80 50
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-79 49
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-56 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metC YP_003618169.1 cystathionine beta-lyase BAC0207 Protein 1e-69 46