Gene Information

Name : lpa_00426 (lpa_00426)
Accession : YP_003617496.1
Strain : Legionella pneumophila 2300/99 Alcoy
Genome accession: NC_014125
Putative virulence/resistance : Virulence
Product : betaine-aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.8
Position : 330849 - 332300 bp
Length : 1452 bp
Strand : +
Note : COG1012, PutA, NAD-dependent aldehyde dehydrogenases [Energy production and conversion]

DNA sequence :
ATGTACATTGATGGAAAATTTACTTTAGCCAAAAGCGGAACTACTCGCGACATTTTTGATCCGGCTAACGGGGAATTGAT
TGCAAGAGTGCCAGAAAGTGCCAAAGAAGATGCCATACTTGCTATCAAAGCAGCGAGAAAAGCCTTCGATGAAGGAGAGT
GGAGAAAATCACTGGCGCTTGATCGAGGCAAATTGTTATTCAAGCTTGCTGATTTGATTCGAGCCAATGCTAAAATGTTG
GCAGAGCTGGAAACTAGAAATTGCGGAAAGCCGTTACCCGAAGCGGAGTTTGATGTCACTGATGCTGCCAATTGCTTTGA
ATTTTACGGTGGGCTTGCGACTAAAATTCATGGTGAAACGATGTCGGTTCCAGCGAATTCATTTAGTTACGTAGTACGTG
AACCCATAGGCGTGTGTGGGCAAATCATTCCATGGAATTTTCCACTGCTTATGGCGGCCTGGAAGCTTGCACCCGCACTT
GCCGCAGGCAATACCGTGGTATTAAAACCATCAGAATTGACCCCGATAACGGCACTTGAGTTATTCAAGTTGATTGATCA
ATGCGGATTTCCCGCGGGCGTGGTTAACCTCATTACTGGGCCGGGTATGGGAGTTGGAGAGGAGTTGGCAAGTAATTCTA
TAGTGGATAAGGTTGCTTTCACCGGAGGATCGGCAACAGGCAGAAAAATCATGCAGGCAGCTACTGGCAATTTGAAAAAA
ATCTCGTTAGAGCTTGGCGGAAAAAATCCAAATATTGTCTTTGCAGACTGTGACCTTGAAATGGCAATCGACGGCGCCCT
TTTTGGTGCTTTTGCAAATCAAGGGGAGGTCTGTTCTGCGGGTTCCCGCTTGCTAGTGGAGCGCTCTATTCACAAAAAAA
TAGTAGAGGGAATGTTGAAAAAAATTCCAAATATCAAGCTTGGCCATGGTTTGGACGCTGGGGTAAAAATGGGGCCTTTG
GTTTCAAGTGCACATCGAGAAAAAGTGGAAAGCTATGTCAAGCTTGGAATGGAAGAAGGGGCCAAATTACTTTGCGGCGG
TAAACGCCCGACAGGCAGTGAATTTGCAAAGGGACATTTTTTCGAGCCAACCATTTTTGATGAAGTGAAATCCACGATGC
GTATTGCTCGTGAAGAAATTTTTGGTCCAGTACTTGTGGTCATCCCCTTTGATACAGAAGAAGAAGCCATTCGCATTGCG
AACGATACTGATTATGGTTTATCTGGGGCTGTATGGACGAAGAGCGTTACTCGAGCCCATCGAGTCACATCTCAAATCCG
TGCCGGGATTCTTTGGGTGAATCATTACCATCCAACCTATAATGAAATGCCTTGGGGCGGATACAAACAAAGTGGAGCGG
GTCGTGAGTTAGGCTTGTATGGCATTGAGAGTTACCTTGAGGTCAAGCAAGTGAATATTAACCTGGATGAAACATCAATT
GGTTGGTACTAA

Protein sequence :
MYIDGKFTLAKSGTTRDIFDPANGELIARVPESAKEDAILAIKAARKAFDEGEWRKSLALDRGKLLFKLADLIRANAKML
AELETRNCGKPLPEAEFDVTDAANCFEFYGGLATKIHGETMSVPANSFSYVVREPIGVCGQIIPWNFPLLMAAWKLAPAL
AAGNTVVLKPSELTPITALELFKLIDQCGFPAGVVNLITGPGMGVGEELASNSIVDKVAFTGGSATGRKIMQAATGNLKK
ISLELGGKNPNIVFADCDLEMAIDGALFGAFANQGEVCSAGSRLLVERSIHKKIVEGMLKKIPNIKLGHGLDAGVKMGPL
VSSAHREKVESYVKLGMEEGAKLLCGGKRPTGSEFAKGHFFEPTIFDEVKSTMRIAREEIFGPVLVVIPFDTEEEAIRIA
NDTDYGLSGAVWTKSVTRAHRVTSQIRAGILWVNHYHPTYNEMPWGGYKQSGAGRELGLYGIESYLEVKQVNINLDETSI
GWY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 8e-77 44
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-70 41
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 4e-71 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 4e-71 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 4e-71 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 9e-71 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lpa_00426 YP_003617496.1 betaine-aldehyde dehydrogenase VFG0082 Protein 5e-71 41