Gene Information

Name : cadA2 (lpa_01606)
Accession : YP_003618350.1
Strain : Legionella pneumophila 2300/99 Alcoy
Genome accession: NC_014125
Putative virulence/resistance : Resistance
Product : cadmium translocating P-type ATPase CadA
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.1.-
Position : 1261238 - 1263379 bp
Length : 2142 bp
Strand : +
Note : COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism]

DNA sequence :
ATGACAGCTCCGCTCACCTTAACCACTTTTTTTGTTGCAGGACTTGATTGTCAGGCTGAAGAACAATTAATCAGGCGGCA
ATTGCAAGCTATCCCTGAAGTGGAAAAGATGGATTTTAATTTTATTGCTGAAGAAGTAACGGTTCATCATCGATTACCCA
CCATTGAACCTATACAACAGCAGATAGAAGCCTTAGGGATGAGCGTGCGCGCCAAACAAAGCACCCCTAGCGACAAGGTT
CAGGAAAAACTTAAATTTGATGCCTCTTGGCAGATTCTTGCATTATCAGGTCTATTGGCTCTTTGCTCCGAAATAGCAGC
TTATCTTTTGGCAACAGAGCAATCTCTATGGGCCATTATTCCTGCCTTACTGGCCATTATTCTCAGTGGACCTCCTACTT
TTAAAAAAGGTTGGCTTGCTTTGCGCACAAAAGCCATGAACATTAACAGTCTAATGCTCATTGCCATAACAGGGGCTATC
TTTATCGGTGATTGGCCTGAGGCGGCTATGGTTACTGTTTTGTTTGCATTGGCGGAACGAATAGAGCGTTATTCCTTAGA
CAAAGCACGTCTGGCTATTCGAAGCTTGATGCAGATTGTTCCTGATGTGGCTCAAGTGAAAACAGCTAATGGTCAATGGC
AAACTTTACTGGTCGAGGAAGTGCCACTGGGTGCTGTTTTTAGAGTTAAGCCTGGTGAGCGTATTCCATTGGATGGTGAG
GTGGTTTCAGGTCAAAGTACAGTCAACCAAGCTCCTATTACCGGGGAATCCATGCCAGTGAGTAAGCAGATAGGTGATTC
TGTTTTTGCCGGCTCTTTAAATGAGCATGGGGCTTTTGAAGCGAAGGTGAGCAAAGCGTCAGGCGATACGCTGCTCGCTA
AAATTGGTAAAGCGATTGAACAGGCGCAAGCTGAGCGGGCCCCAACGCAACGATTTGTTGACGAATTTGCAAGATACTAT
ACGCCTATTATGGTATTGATTGCTGTTCTTGTCGCTTTAATTCCTCCTTTCGTGTTGGGATATTCTTTTTATGATTGGAT
CTATAAGGCGTTGACTTTATTAGTTATTGCCTGTCCTTGTGCCCTGGTCATTTCAACACCAGTAACAGTGGTGAGTGGCT
TGGCTGCCTCTGCCAAACATGGGCTTCTCATCAAAGGAGGAAGCTATTTAGAGACGGGTTATCGCTTACAGTTAATTGCA
CTGGATAAAACTGGTACCTTAACAGAGGGCAAACCGGTGGTAACCGATTTTATTACTTATGATAAAAGTCAAACCAATGA
ACACTTGTTGTTGCTTGCTGCAAGTCTTGACAGCCACTCCGAGCACCCCGTAGCTCATGCCCTAGTGGCATATTGGCAGC
AAGAGCATCCTGATAAATCATTGCTTTCAGTGGAACGGTTTTCAGCGCTTCCTGGGCGAGGCGTGAAAGGTGCCATCCAG
GGGGAATTGTATTATGTAGGCAATCATCAATTAGCAGAAGACAACAAAGTCTGTTGTTTAGAGGTTGAGCAAGAATTGAA
ACGACTGGAAGAAGAAGGAAAAACTACTGTTATATTAAGCAATAGCACTACGGCCTTGGCTATTTTTGCAGTGGCAGATA
CGCTTCGAGCCAACAGTCGAGAGGCGATTGAATCATTGCATCGACAAAGGATAAAAACGGCGATGTTAACAGGTGATAAT
GCTCTAACCGCTCAAGCCATTGCCAAACAAGTCGGCATTGATGAAATCCAAGCTAATATATTACCAACAGAAAAAATGCA
GGCTATCAATAAACTCTTAGAACAATATCAGGCTGTGGGCATGGTGGGAGATGGCATTAATGATGCACCTGCTTTAGCGA
AAGCCACTATTAGCTTTGCGATGGGTAAGGGAACAGATACCGCTTTAGAGACAGCGGATGTGGTATTAATGAATGATAAT
TTAGCCATGCTTCCTCTGTACATTGACTTAAGCCGGAAGACAGTGCGAATTTTATGGCAAAACATTAGTCTATCCTTGGT
TATTAAAACGGTGTTTTTTATTTTAGCACTTGGAGGAATGGCTACCCTTTGGATGGCGGTTTTTGCTGACATGGGGGCTA
GTTTGATTGTGGTTATGAATGGGCTACGATTGTTGAATTCAAATAAAACGAAGAATCATTAA

Protein sequence :
MTAPLTLTTFFVAGLDCQAEEQLIRRQLQAIPEVEKMDFNFIAEEVTVHHRLPTIEPIQQQIEALGMSVRAKQSTPSDKV
QEKLKFDASWQILALSGLLALCSEIAAYLLATEQSLWAIIPALLAIILSGPPTFKKGWLALRTKAMNINSLMLIAITGAI
FIGDWPEAAMVTVLFALAERIERYSLDKARLAIRSLMQIVPDVAQVKTANGQWQTLLVEEVPLGAVFRVKPGERIPLDGE
VVSGQSTVNQAPITGESMPVSKQIGDSVFAGSLNEHGAFEAKVSKASGDTLLAKIGKAIEQAQAERAPTQRFVDEFARYY
TPIMVLIAVLVALIPPFVLGYSFYDWIYKALTLLVIACPCALVISTPVTVVSGLAASAKHGLLIKGGSYLETGYRLQLIA
LDKTGTLTEGKPVVTDFITYDKSQTNEHLLLLAASLDSHSEHPVAHALVAYWQQEHPDKSLLSVERFSALPGRGVKGAIQ
GELYYVGNHQLAEDNKVCCLEVEQELKRLEEEGKTTVILSNSTTALAIFAVADTLRANSREAIESLHRQRIKTAMLTGDN
ALTAQAIAKQVGIDEIQANILPTEKMQAINKLLEQYQAVGMVGDGINDAPALAKATISFAMGKGTDTALETADVVLMNDN
LAMLPLYIDLSRKTVRILWQNISLSLVIKTVFFILALGGMATLWMAVFADMGASLIVVMNGLRLLNSNKTKNH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 7e-153 52
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 7e-116 41
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 8e-116 41
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 3e-118 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA2 YP_003618350.1 cadmium translocating P-type ATPase CadA BAC0298 Protein 1e-148 52
cadA2 YP_003618350.1 cadmium translocating P-type ATPase CadA BAC0461 Protein 1e-76 41