Gene Information

Name : cadA (lpa_01540)
Accession : YP_003618309.1
Strain : Legionella pneumophila 2300/99 Alcoy
Genome accession: NC_014125
Putative virulence/resistance : Resistance
Product : cadmium translocating P-type ATPase CadA
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.1.-
Position : 1211222 - 1213363 bp
Length : 2142 bp
Strand : +
Note : COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism]

DNA sequence :
ATGACAGTACCTTTAAATGAAACCAAATTTTTTGTTGCAGGTCTTGATTGTCCAGCGGAAGAGCAACTAATCAGAAAGCA
GTTACAGGATATTCCTGAAGTGGAGCAGTTGGATTTTAATTTTATTGCTGAAGAAGTTACCATTCATCACCGGTTGGCTT
CAAGTGAAGAATTGCAAAAACGCATTGAGGCGTTGGGAATGAATGTTCGAACTCTGGAAAGCACTTTGCCTATACCACAA
AGAAAACAATTATCTTTGGATTTTTCCTGGAAAATTATTGGACTAGCAGGTTTTCTTGCCCTATTTTCTGAGCTGGCAGC
TTATTTTTTAGCTACAGAACAATCCGTTTGGACTATTCTTCCAGCTTTGTTGGCTATTGGTCTTAGTGGGCCTTCTACCT
TTAAAAAAGGGTGGCTTGCCTTAGGGACTAAAACAATGAATATCAATAGCTTGATGTTCATTGCGATAGCAGGGGCTGTT
CTTATTGGAGAGTGGCCTGAAGCGGCAATGGTGACTGTTTTATTTGCATTGGCCGAACGTATCGAGCGCTACTCCTTAGA
TAAAGCACGTCTTGCGATTCGAAGCTTAATGCAAATTGCCCCTGAGGTGGCTTCAGTGAAACAGGACGATGGTCAATGGC
AAACCTTGGCCATTGAAAAAGTGGTGCCTGGTGCTATTTTTAGAGTAAAACCTGGAGAGCGTATTCCCCTGGATGGCGTG
GTTATTTCAGGTCAGAGCACGGTCAATCAAGCGCCGATTACTGGTGAATCAATGCCAATAACAAAAAAAGTGGGTGATTT
GGTTTTTGCAGGAACATTAAATGAGCACGGCGCGTTTGAAGTGCAGGTCAGTAAAGCGTCAGGCGATACATTGCTTGCTA
AAATTGGTAAAGCGATAGAGCAAGCGCAAGCGGATCGAGCTCCAACACAACGATTTGTTGATCAGTTTTCTAAATATTAT
ACTCCAATTATGGTATTGATGGCTTTTTTTGTTGCATTAATTCCACCTTTAGCATTTGGTTATCCTTTTTATGATTCTCT
TTATAAGTCACTGACTTTATTAGTTATTGCTTGCCCTTGCGCTTTAGTGATTTCAACACCTGTGACTGTTGTAAGCGGTC
TTGCAGCGGCAGCAAAACAAGGGCTTCTTATTAAAGGAGGAAGCTACTTAGAGGTTGGTCATCGACTGAGGTTAATTGCT
TTAGATAAGACAGGTACTTTAACGGAAGGAAAGCCAGTTGTAACTGACTTCATAGCTTGGGATGAAAATCGAACTAAGGA
TAGTTTGTTATTGTTAGCTGCAAGCCTTGATAGTCACTCAGAGCATCCAGTCGCTAATGCCTTAGTACAGTACTGGCAAC
AGGAACAACCTCAAAACGCTTTACTTGAAATTGAGCAATTTTCAGCGCTTCCTGGACGAGGAGTAAAGGGATTAGTGGGT
CAAGAACTCTATTTTGTAGGCAATCATCAGTTAGCTGAAGACAATCAGGTATGCAATCATTTTGTCGAACAAGAGCTGAA
GCGCTTGGAGGAAGAAGGTAAAACGACCGTAATATTAAGTAATGCTACGACTGTTTTGGCTATTTTTGCAGTAGCTGATA
CTTTACGTGTTACAAGCCAACAGGCGATTGCACAACTACATGAACGGGGGATAAAAACCGCGATGTTAACGGGAGACAAT
GCGGTAACGGCTCAGGCTATTGCTAAAAAAGTAGGTATTGATGAAGTAAATGCGAATATATTACCTGCTGAAAAACTGCA
AGCGATTAATCGTCTTTTAGAACACTATCATAGTGTTGGTATGGTAGGAGATGGAATTAATGATGCACCTGCATTGGCAA
AAGCTACCGTGAGTTTTGCGATGGGGAAAGGAACAGATACCGCCTTAGAAACAGCAGACGTTGCTCTCATGAATGATAAT
CTAGCAAGACTTCCCTTTTATATTGATTTAAGTCGTAAGACGGCACGCACTCTTTATCAAAACATCAGTTTATCTATTGC
GATTAAAGGCATTTTCTTTATTTTAGCTCTTGTAGGATATGCAACTTTATGGATGGCGGTTTTTGCAGATATGGGAGCGA
GTTTAATCGTAGTAGCTAATGGATTGCGATTGTTGTATTTGTCTCCAGAAAGTAATGAATAA

Protein sequence :
MTVPLNETKFFVAGLDCPAEEQLIRKQLQDIPEVEQLDFNFIAEEVTIHHRLASSEELQKRIEALGMNVRTLESTLPIPQ
RKQLSLDFSWKIIGLAGFLALFSELAAYFLATEQSVWTILPALLAIGLSGPSTFKKGWLALGTKTMNINSLMFIAIAGAV
LIGEWPEAAMVTVLFALAERIERYSLDKARLAIRSLMQIAPEVASVKQDDGQWQTLAIEKVVPGAIFRVKPGERIPLDGV
VISGQSTVNQAPITGESMPITKKVGDLVFAGTLNEHGAFEVQVSKASGDTLLAKIGKAIEQAQADRAPTQRFVDQFSKYY
TPIMVLMAFFVALIPPLAFGYPFYDSLYKSLTLLVIACPCALVISTPVTVVSGLAAAAKQGLLIKGGSYLEVGHRLRLIA
LDKTGTLTEGKPVVTDFIAWDENRTKDSLLLLAASLDSHSEHPVANALVQYWQQEQPQNALLEIEQFSALPGRGVKGLVG
QELYFVGNHQLAEDNQVCNHFVEQELKRLEEEGKTTVILSNATTVLAIFAVADTLRVTSQQAIAQLHERGIKTAMLTGDN
AVTAQAIAKKVGIDEVNANILPAEKLQAINRLLEHYHSVGMVGDGINDAPALAKATVSFAMGKGTDTALETADVALMNDN
LARLPFYIDLSRKTARTLYQNISLSIAIKGIFFILALVGYATLWMAVFADMGASLIVVANGLRLLYLSPESNE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 2e-158 52
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 4e-122 43
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 3e-121 42
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 2e-121 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_003618309.1 cadmium translocating P-type ATPase CadA BAC0298 Protein 8e-157 52