Gene Information

Name : clpC (HMPREF0675_3324)
Accession : YP_003580509.1
Strain : Propionibacterium acnes SK137
Genome accession: NC_014039
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 352990 - 355524 bp
Length : 2535 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGTTCGAACGGTTCACCGATCGGGCCCGCCGGGTCGTCGTCCTGGCCCAGGATGAGGCCAAGGCCCTGAACCACAATTA
CATTGGCACTGAGCACCTGCTGCTCGGGCTCATTAGCGAGGGCGAGGGAGTCGCTGCCAAGGCTCTCGAGTCCCTTGACA
TTTCACTGGAGGCTGTTCGCGCCCAGGTGGAGGAGATTATTGGTCACGGCACTTCGACGCCGACGGGCCATATTCCCTTT
ACCCCGCGTGCCAAGAAGGTTCTTGAGCTGAGCCTGCGCGAAGCCCTCCAGATGAATCATTCGTACATTGGCACCGAGCA
CATTCTGCTTGGCCTTATCCGGGAGGGAGAAGGCGTCGCTGCTCAGGTACTGATCCGGCTGGGTGCTGACCTCAACACGG
TGCGCAATAGCGTCTTGCAACTGTTGCAGGGATATCAGGGCGACGAGCGTCAGGCCGCCACTTCCGGTGCCCCCGAGGCC
GGACCGCAGCAGTCCTCGGCGACGATTCTTGACCAATTCGGTCGCAACCTTACCGAGGCCGCCCGCGACGGCGAGCTCGA
CCCGGTTATCGGGCGTGAGAGGGAAATCGAACGAGTCATGGTGGTGCTGAGCCGGCGCACCAAGAATAACCCGGTTCTTA
TTGGTGAGCCTGGCGTCGGTAAGTCTGCTTGTGTCGAGGGCCTGGCTCAGGCCATCGTGCGTGGAGACGTTCCCGAGACT
CTGCGTGACAAGAAGATTTACTCCCTGGACCTTGGCTCCATGGTTGCGGGATCGCGTTACCGCGGTGATTTCGAGGAGAG
GATGAAGAAGGTCCTCAAGGAGATAAAAAATCGCGGGGACATCATCCTGTTCATCGACGAGATCCACACCCTTGTCGGCG
CCGGTGCCGCTGAAGGGGCAATCGACGCTGCCAGCATGCTCAAGCCGATGCTGGCTCGCGGCGAGCTGCAGACTATCGGT
GCGACGACCCTTGATGAGTACCGTAAGTACATCGAGAAGGACGCCGCCCTGGAGCGTCGCTTCCAGCCGATCCAGGTAGA
CGAGCCCTCGATCCCCCTGGCCATCGAGATCCTTAAGGGTCTGCGCGACCGGTACGAGGCCCACCACAAGATCACCATCA
CCGACGAGGCAATCACCTCCGCAGCGAATCTTGCGTCCCGTTACATCCAAGACCGCTTCCTGCCAGACAAGGCCATCGAT
CTCATTGACGAGGCCGGTGCCCGGATGAACATCCGCCGCATGACGGCCCCGCCGGATCTGCGCGAGTTCGACGAGCGGAT
TGCTCGTGTGCGAGTGGAGAAAGAGGCCGCCATCGACGCCCAGGATTTCGAGCGTGCTGCTGGGCTGCGCGACGACGAAA
AGAAACTTCTCGCCGAGCGTGAGGCCAAGGAGGAGGAGTGGAAGCAGGGTGACGAGTCGGTGCCAGCCGTGGTCGGCCCT
GATGAGATCGCCGAGGTGCTCTCTGGAGCTACCGGAATTCCGGTCTTCAAGCTCACGGAGGAGGAATCCCAGCGTCTGCT
CCACATGGAGGACGAGATCGGCAAGCGTTACGTCGGCCAGGAGGACGCCGTTAAGGCCCTGTGCCGCTCTATCCGACGTA
CCCGTGCCGGCCTCAAGGACCCGAAGCGTCCGGCAGGTTCGTTCATTTTTGCTGGCCCGTCGGGTGTTGGTAAGACCGAG
CTCACCAAGGCGCTCACCGAGTTCCTCTTTGGCGACGAGGACGCCCTCATCACCCTCGACATGAGCGAGTACTCCGAGAA
ACACACCGCTTCGCGGATGTTTGGGTCCCCGCCTGGATTCGTCGGGTACGAGGAGGGCGGCCAGCTCACCGAGAAGGTGC
GCCGCAAGCCGTTCAGCGTCATTCTCTTTGACGAGATTGAAAAGGCCCACCCCGATATCTTCAACTCTCTGTTGCAGATT
CTTGACGAGGGACGTCTTACTGACGCCCAGGGCCGTGTAGTGGACTTTAAGAACACCGTCATTGTGCTGACGACCAACCT
TGGCACCCGCGACATTTCCAAATCAGTCAATCTCGGCTTTTCCAAGGCCGACGACGTCGAGTCTAGCTACGAGAAGATGA
AGGCCAAGGTTACCGAGGAGCTCAAGGGACACTTCCGTCCCGAGTTCCTCAACCGCCTTGACGAGATCATCGTCTTCCAT
CAGCTCACCCAGCCCGACATCCTACGGATTGTCGACCTCATGGTGGGGCAACTGGAGGATCGTCTGGCCGACAAGGACAT
GGGTATCGAGGTCACTCCGGCTGCCAAGGAACTGCTGTCCACGCGTGGTTTCGACCCGCTGCTCGGTGCTCGTCCGCTGC
GCCGGACGATCCAGCGCGACATCGAGGACGTCCTAGCCGAGAAGATCCTCTTCGGGGAGGTCAAACCTGGTCAGATCGTG
GTGGTCGATGCTGCCCCGGAGGGTTCCGAGGAGCCGTTCGTCTTCACCGGCACGGAGCGCTCAGAGCTGCCTGACGAGGT
TCCTCCTGAGCTCACCTCTTCGGCAGGGGAAAATAACAGGGGGCAGCAGGGCTGA

Protein sequence :
MFERFTDRARRVVVLAQDEAKALNHNYIGTEHLLLGLISEGEGVAAKALESLDISLEAVRAQVEEIIGHGTSTPTGHIPF
TPRAKKVLELSLREALQMNHSYIGTEHILLGLIREGEGVAAQVLIRLGADLNTVRNSVLQLLQGYQGDERQAATSGAPEA
GPQQSSATILDQFGRNLTEAARDGELDPVIGREREIERVMVVLSRRTKNNPVLIGEPGVGKSACVEGLAQAIVRGDVPET
LRDKKIYSLDLGSMVAGSRYRGDFEERMKKVLKEIKNRGDIILFIDEIHTLVGAGAAEGAIDAASMLKPMLARGELQTIG
ATTLDEYRKYIEKDAALERRFQPIQVDEPSIPLAIEILKGLRDRYEAHHKITITDEAITSAANLASRYIQDRFLPDKAID
LIDEAGARMNIRRMTAPPDLREFDERIARVRVEKEAAIDAQDFERAAGLRDDEKKLLAEREAKEEEWKQGDESVPAVVGP
DEIAEVLSGATGIPVFKLTEEESQRLLHMEDEIGKRYVGQEDAVKALCRSIRRTRAGLKDPKRPAGSFIFAGPSGVGKTE
LTKALTEFLFGDEDALITLDMSEYSEKHTASRMFGSPPGFVGYEEGGQLTEKVRRKPFSVILFDEIEKAHPDIFNSLLQI
LDEGRLTDAQGRVVDFKNTVIVLTTNLGTRDISKSVNLGFSKADDVESSYEKMKAKVTEELKGHFRPEFLNRLDEIIVFH
QLTQPDILRIVDLMVGQLEDRLADKDMGIEVTPAAKELLSTRGFDPLLGARPLRRTIQRDIEDVLAEKILFGEVKPGQIV
VVDAAPEGSEEPFVFTGTERSELPDEVPPELTSSAGENNRGQQG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 71

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_003580509.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 0.0 58
clpC YP_003580509.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 4e-152 51