Gene Information

Name : guaA (HMPREF0675_4821)
Accession : YP_003581953.1
Strain : Propionibacterium acnes SK137
Genome accession: NC_014039
Putative virulence/resistance : Unknown
Product : GMP synthase (glutamine-hydrolyzing), C-terminal domain protein
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1879926 - 1881500 bp
Length : 1575 bp
Strand : -
Note : identified by match to protein family HMM PF00117; match to protein family HMM PF00958; match to protein family HMM TIGR00884; match to protein family HMM TIGR00888

DNA sequence :
GTGGGCCATAGACTCGCCTTCATGGAACAACTTCACGACGTCGTTCTGGTGGTCGACTTCGGCGCGCAGTACGCCCAGCT
CATTGCCCGCCGGGTGCGTGAGGCGAATGTTTACTCCGAGATCGTCCCGCATAACATGCCAGTGCGCGACATGCTCGCTA
AGGAACCCGCCGCCATTATTCTTTCGGGTGGTCCGGCCTCGGTCTACGCAGAGGGCGCCCCGAGCGTCGACCCGGCGTTG
TTTAACGCTGGTGTGCCGGTGCTGGGCATCTGCTATGGATTCCAGGCCATGGCCCAGGCTCTCGGCGGTCAGGTGGCTCA
TACCGGAGCATCGGAGTATGGACGCACCAGCCTGTGCATTACGTCCGCGGGGCAGCTTCTGTCCCGTATTCCCCACACCA
TCAGCGTGTGGATGAGTCACGGCGATTCCGTCTCCCGTGCCCCGGAGGGATTTTCGACGTTGGCCCGCACTGCGGGTGCG
CCGGTGGCGGCGTTTGAAGACGTTGAGCGCAGGCTCGTTGGCGTGCAGTGGCACCCCGAAGTGCACCACACGGAGTCCGG
ACAGACGGTGCTCGAGCACTTCCTTTTCGACATTGCCGGATGCCGTCCTGACTGGAATGCTAGCTCGATCGTCGGCGACC
AGATCGCGCAGATTCGTGGTCAGGTTGGTGACCGGCGCGTCATCTGCGGACTGTCGGGCGGCGTCGATTCTGCTGTTGCT
GCGGCTTTGGTGCAGCGCGCTGTGGGCGACCAGCTCACCTGCGTTTTCGTCGATCACGGACTGCTGCGTCAAGGGGAGGC
TGAGCAAGTCAAGAATGACTTCGTCGCCGCCACGGGCGCTGATTTGGTGGTGGCTGATGAGTCGCAGCGCTTCCTGGATG
CCCTCGCCGGGGTCACCGATCCTGAGACCAAGCGCAAGATCATTGGACGCGAGTTCATTCGGACCTTTGAGGATGTTGCC
AAGCGTCTCAACGCTGACCAGCCGATCGACTTCTTGGTGCAGGGAACTTTGTATCCCGACGTCGTCGAGTCTGGTGGCGG
CGAGGGCGCCGCCAATATCAAGAGCCACCATAATGTTGGTGGGCTCCCCGACGACCTCCAGTTCAGTCTCGTTGAGCCAT
TGCGCACCCTCTTTAAGGACGAGGTGCGAGCCGTCGGACTCGAACTTGGTCTGCCCGAGGACATCGTGTGGCGTCAGCCC
TTCCCGGGCCCGGGGCTGGCTATCCGCATTATTGGCGAAGTCACCGCGGAGCGTCTGGAGGTGTTACGCACTGCCGATGC
CATCACACGTGAGGAAATGGGGGCCGCGGGCCTGGATCGCAAGGTATGGCAGTGCCCGGTCGTCCTCCTCAGTGATGTCC
ATTCGGTAGGGGTACAGGGTGACGGGCGTACTTATGGTTCTCCCATTGTGCTTCGCCCGGTGACGAGCGAGGACGCCATG
ACTGCGGACTGGGCACGTATCCCGTACGACGTGCTGGAAAAGATCTCGACTCGCATTACGAATGCGTGTCCGCAAATCAA
CCGGGTGGTACTCGACATCACATCTAAGCCGCCGGCTACCATCGAGTGGGAGTGA

Protein sequence :
MGHRLAFMEQLHDVVLVVDFGAQYAQLIARRVREANVYSEIVPHNMPVRDMLAKEPAAIILSGGPASVYAEGAPSVDPAL
FNAGVPVLGICYGFQAMAQALGGQVAHTGASEYGRTSLCITSAGQLLSRIPHTISVWMSHGDSVSRAPEGFSTLARTAGA
PVAAFEDVERRLVGVQWHPEVHHTESGQTVLEHFLFDIAGCRPDWNASSIVGDQIAQIRGQVGDRRVICGLSGGVDSAVA
AALVQRAVGDQLTCVFVDHGLLRQGEAEQVKNDFVAATGADLVVADESQRFLDALAGVTDPETKRKIIGREFIRTFEDVA
KRLNADQPIDFLVQGTLYPDVVESGGGEGAANIKSHHNVGGLPDDLQFSLVEPLRTLFKDEVRAVGLELGLPEDIVWRQP
FPGPGLAIRIIGEVTAERLEVLRTADAITREEMGAAGLDRKVWQCPVVLLSDVHSVGVQGDGRTYGSPIVLRPVTSEDAM
TADWARIPYDVLEKISTRITNACPQINRVVLDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-173 70
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-142 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-142 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-142 51